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The Future of Radiotherapy in Bladder Cancer

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Treating Urothelial Bladder Cancer

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References

  1. Mirza A, Choudhury A. Bladder preservation for muscle invasive bladder cancer. Bl Cancer. 2016;2:151–63.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Kotwal S, Choudhury A, Johnston C, et al. Similar treatment outcomes for radical cystectomy and radical radiotherapy in invasive bladder cancer treated at a United Kingdom specialist treatment center. Int J Radiat Oncol Biol Phys. 2008;70(2):456–63.

    Article  PubMed  Google Scholar 

  3. James ND, Hussain SA, Hall E, et al. Radiotherapy with or without chemotherapy in muscle-invasive bladder cancer. N Engl J Med. 2012;366:1477–88.

    Article  CAS  PubMed  Google Scholar 

  4. Hoskin PJ, Rojas AM, Bentzen SM, et al. Radiotherapy with concurrent Carbogen and nicotinamide in bladder carcinoma. J Clin Oncol. 2010;28:4912–8.

    Article  PubMed  Google Scholar 

  5. Choudhury A, Swindell R, Logue JP, et al. Phase II study of conformal hypofractionated radiotherapy with concurrent gemcitabine in muscle-invasive bladder cancer. J Clin Oncol. 2011;29:733–8.

    Article  PubMed  Google Scholar 

  6. Coppin CM, Gospodarowicz MK, James K, et al. Improved local control of invasive bladder cancer by concurrent cisplatin and preoperative or definitive radiation. The National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 1996;14:2901–7.

    Article  CAS  PubMed  Google Scholar 

  7. Lalondrelle S, Huddart R. Improving radiotherapy for bladder cancer: an opportunity to integrate new technologies. Clin Oncol (R Coll Radiol). 2009;21:380–4.

    Article  CAS  Google Scholar 

  8. Lalondrelle S, Huddart R, Warren-Oseni K, et al. Adaptive-predictive organ localization using cone-beam computed tomography for improved accuracy in external beam radiotherapy for bladder cancer. Int J Radiat Oncol Biol Phys. 2011;79:705–12.

    Article  PubMed  Google Scholar 

  9. Foroudi F, Pham D, Rolfo A, et al. The outcome of a multi-centre feasibility study of online adaptive radiotherapy for muscle-invasive bladder cancer TROG 10.01 BOLART. Radiother Oncol. 2014;111:316–20.

    Article  PubMed  Google Scholar 

  10. Huddart RA, Hall E, Hussain SA, et al. Randomized noninferiority trial of reduced high-dose volume versus standard volume radiation therapy for muscle-invasive bladder cancer: results of the BC2001 trial (CRUK/01/004). Int J Radiat Oncol Biol Phys. 2013;87:261–9.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Cowan R, McBain C, Ryder W, et al. Radiotherapy for muscle-invasive carcinoma of the bladder: results of a randomized trial comparing conventional whole bladder with dose-escalated partial bladder radiotherapy. Int J Radiat Oncol Biol Phys. 2004;59:197–207.

    Article  PubMed  Google Scholar 

  12. Wright JL, Lin DW, Porter MP. The association between extent of lymphadenectomy and survival among patients with lymph node metastases undergoing radical cystectomy. Cancer. 2008;112:2401–8.

    Article  PubMed  Google Scholar 

  13. Tunio MA, Hashmi A, Qayyum A, et al. Whole-pelvis or bladder-only chemoradiation for lymph node-negative invasive bladder cancer: single-institution experience. Int J Radiat Oncol Biol Phys. 2012;82:457–62.

    Article  Google Scholar 

  14. Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature. 2009;461:1071–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Lavin MF. ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks. Oncogene. 2007;26:7749–58.

    Article  CAS  PubMed  Google Scholar 

  16. Choudhury A, Nelson LD, Teo MTW, Chilka S, Bhattarai S, Johnston CF, et al. MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle invasive bladder cancer. Cancer Res. 2010;70(18):7017–26.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Laurberg JR, Brems-Eskildsen AS, Nordentoft I, et al. Expression of TIP60 (tat-interactive protein) and MRE11 (meiotic recombination 11 homolog) predict treatment-specific outcome of localised invasive bladder cancer. BJU Int. 2012;110:E1228–36.

    Article  CAS  PubMed  Google Scholar 

  18. Nordsmark M, Overgaard M, Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol. 1996 Oct;41(1):31–9.

    Article  CAS  PubMed  Google Scholar 

  19. Quintiliani M. The oxygen effect in radiation inactivation of DNA and enzymes. Int J Radiat Biol Relat Stud Phys Chem Med. 1986;50(4):573–94.

    Article  CAS  PubMed  Google Scholar 

  20. Eustace A, Irlam JJ, Taylor J, et al. Necrosis predicts benefit from hypoxia-modifying therapy in patients with high risk bladder cancer enrolled in a phase III randomised trial. Radiother Oncol. 2013;108:40–7.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Hunter BA, Eustace A, Irlam JJ, et al. Expression of hypoxia-inducible factor-1alpha predicts benefit from hypoxia modification in invasive bladder cancer. Br J Cancer. 2014;111:437–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Yang L, Williamson A, Irlam J, et al. A hypoxia transcriptomic signature predicting benefit from hypoxia-modifying treatment for high risk bladder cancer patients. In: NCRI cancer conference. Liverpool; 2016. http://abstracts.ncri.org.uk/abstract/a-hypoxia-transcriptomic-signature-predicting-benefit-from-hypoxia-modifying-treatment-for-high-risk-bladder-cancer-patients/

  23. Mehta S, Illidge T, Choudhury A. Immunotherapy with radiotherapy in urological malignancies. Curr Opin Urol. 2016;26:514–22.

    Article  PubMed  Google Scholar 

  24. Demaria S, Golden EB, Formenti SC. Role of local radiation therapy in cancer immunotherapy. JAMA Oncol. 2015;1:1325–32.

    Article  PubMed  Google Scholar 

  25. Wu CT, Chen WC, Chang YH, et al. The role of PD-L1 in the radiation response and clinical outcome for bladder cancer. Sci Rep. 2016;6:19740.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Rosenberg JE, Hoffman-Censits J, Powles T, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet. 2016;387:1909–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Bellmunt J, Mullane SA, Werner L, et al. Association of PD-L1 expression on tumor-infiltrating mononuclear cells and overall survival in patients with urothelial carcinoma. Ann Oncol. 2015;26:812–7.

    Article  CAS  PubMed  Google Scholar 

  28. Joseph N, Dovedi SJ, Thompson C, et al. Pre-treatment lymphocytopaenia is an adverse prognostic biomarker in muscle-invasive and advanced bladder cancer. Ann Oncol. 2016;27:294–9.

    Article  CAS  PubMed  Google Scholar 

  29. Hafeez S, Koh M, Sohaib A, Huddart R. The role of functional MRI to characterise tumour boost delineation in patients undergoing radical radiotherapy for muscle invasive bladder cancer (MIBC). In: NCRI cancer conference. Liverpool; 2012. http://abstracts.ncri.org.uk/abstract/the-role-of-functional-mri-to-characterise-tumour-boost-delineation-in-patients-undergoing-radical-radiotherapy-for-muscle-invasive-bladder-cancer-mibc-2/

  30. Mangar S, Thompson A, Miles E, et al. A feasibility study of using gold seeds as fiducial markers for bladder localization during radical radiotherapy. Br J Radiol. 2007;80:279–83.

    Article  CAS  PubMed  Google Scholar 

  31. Chai X, van Herk M, van de Kamer JB, et al. Behavior of lipiodol markers during image guided radiotherapy of bladder cancer. Int J Radiat Oncol Biol Phys. 2010;77:309–14.

    Article  CAS  PubMed  Google Scholar 

  32. Hafeez S, Warren-Oseni K, McNair HA, et al. Prospective study delivering simultaneous integrated high-dose tumor boost (≤70 Gy) with image guided adaptive radiation therapy for radical treatment of localized muscle-invasive bladder cancer. Int J Radiat Oncol Biol Phys. 2016;94:1022–30.

    Article  PubMed  Google Scholar 

  33. Hafeez S, Huddart R. Advances in bladder cancer imaging. BMC Med. 2013;11:104.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Lagendijk JJ, Raaymakers BW, van Vulpen M. The magnetic resonance imaging-linac system. Semin Radiat Oncol. 2014;24(3):207–9.

    Article  PubMed  Google Scholar 

  35. Vestergaard A, Hafeez S, Muren LP, et al. The potential of MRI-guided online adaptive re-optimisation in radiotherapy of urinary bladder cancer. Radiother Oncol. 2016;118:154–9.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Ministry of Health, Colombo, Sri Lanka

    Nuradh Joseph

  2. Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK

    Rohan Iype & Ananya Choudhury

  3. Division of Cancer Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

    Ananya Choudhury

Authors
  1. Nuradh Joseph
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  2. Rohan Iype
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  3. Ananya Choudhury
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Corresponding author

Correspondence to Ananya Choudhury .

Editor information

Editors and Affiliations

  1. University of Turin, Torino, Italy

    Francesco Soria

  2. University of Turin, Torino, Italy

    Paolo Gontero

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Joseph, N., Iype, R., Choudhury, A. (2018). The Future of Radiotherapy in Bladder Cancer. In: Soria, F., Gontero, P. (eds) Treating Urothelial Bladder Cancer . Springer, Cham. https://doi.org/10.1007/978-3-319-78559-2_16

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  • DOI: https://doi.org/10.1007/978-3-319-78559-2_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-78558-5

  • Online ISBN: 978-3-319-78559-2

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