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Standards for Ocular Toxicology and Inflammation pp 141–168Cite as

Spontaneous Incidence of Ocular Abnormalities in Laboratory Animals

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Abstract

This chapter provides incidence data on spontaneous ophthalmic abnormalities in the most commonly used species in toxicological and pharmacokinetic drug research. This data can be used to better differentiate test article-related ocular findings from background incidental lesions to enhance interpretation of ophthalmic findings, improve speed of drug development, reduce the number of studies that need to be repeated, and thus reduce the overall number of animals used in toxicology research and drug development.

Endorsed by the American College of Veterinary Ophthalmologists (ACVO).

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Acknowledgments

The authors thank the following contract research organizations and individuals for assistance in collection of the data for this chapter:

Charles River Laboratories, Wil Research, Ashland, Ohio. Robert Wally, Brian Ronk and Jeanette Howell

Charles River Laboratories, Reno, Nevada. Dr. Margaret Collins

Charles River Laboratories, Horsham, Pennsylvania. Dr. Douglas Learn

Envigo, East Millstone, New Jersey. Christopher Blum

MPI Research, Mattawan, Michigan

Powered Research, Research Triangle Park, North Carolina. Dr. David Culp, Justin Prater

Author information

Authors and Affiliations

  1. MPI Research Ophthalmology Services, 54943 N Main St., Mattawan, MI, USA

    Brian C. Gilger & Joshua T. Bartoe

  2. Animal Eye Center of New Jersey, Little Falls, NJ, USA

    Michael H. Brown

  3. Animal Ophthalmology Clinic, Dallas, TX, USA

    Robert J. Munger

  4. V&O Services Inc., Saint-Lazare, QC, Canada

    Martin Bussieres

  5. Veterinary Vision, Inc., San Carlos, CA, USA

    Cynthia S. Cook

Authors
  1. Brian C. Gilger
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  2. Michael H. Brown
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  3. Robert J. Munger
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  4. Joshua T. Bartoe
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  5. Martin Bussieres
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  6. Cynthia S. Cook
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Corresponding author

Correspondence to Brian C. Gilger .

Editor information

Editors and Affiliations

  1. Department of Clinical Sciences, North Carolina State University, Raleigh, NC, USA

    Brian C. Gilger

  2. Veterinary Vision, San Francisco, CA, USA

    Cynthia S. Cook

  3. Veterinary Ophthalmology Services, Inc., Little Falls, NJ, USA

    Michael H. Brown

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Gilger, B.C., Brown, M.H., Munger, R.J., Bartoe, J.T., Bussieres, M., Cook, C.S. (2018). Spontaneous Incidence of Ocular Abnormalities in Laboratory Animals. In: Gilger, B., Cook, C., Brown, M. (eds) Standards for Ocular Toxicology and Inflammation. Springer, Cham. https://doi.org/10.1007/978-3-319-78364-2_4

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