Abstract
The goal of this chapter is to provide consensus for the harmonization of preclinical terminology for ultimate adoption on studies submitted to US Food and Drug Administration (FDA) and other global regulatory agencies. Included is a list of descriptive-based terminology for anatomical subsections of the eye with associated definitions and synonyms. We are recommending use of this harmonized terminology for description of common lesions observed spontaneously or associated with test article-induced changes. The tables provided contain listings for all necessary base-root lesions, while recommended modifiers are addressed in the section text. Additionally, there are representative images for selected lesions to provide the reader specific examples of the ocular changes they may encounter on ophthalmology examinations.
Endorsed by the American College of Veterinary Ophthalmologists (ACVO).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Van Herck H, et al. Histological changes in the orbital region of rats after orbital puncture. Lab Anim. 1992;26(1):53–8.
Timm KI. Orbital venous anatomy of the rat. Lab Anim Sci. 1979;29(5):636–8.
Timm KI. Orbital venous anatomy of the Mongolian gerbil with comparison to the mouse, hamster and rat. Lab Anim Sci. 1989;39(3):262–4.
Djeridane Y. The harderian gland of desert rodents: a histological and ultrastructural study. J Anat. 1992;180(Pt 3):465–80.
Djeridane Y. Comparative histological and ultrastructural studies of the harderian gland of rodents. Microsc Res Tech. 1996;34(1):28–38.
Bhatt PN, Percy DH, Jonas AM. Characterization of the virus of sialodacryoadenitis of rats: a member of the coronavirus group. J Infect Dis. 1972;126(2):123–30.
Jacoby RO, Bhatt PN, Jonas AM. Pathogenesis of sialodacryoadenitis in gnotobiotic rats. Vet Pathol. 1975;12:196.
Weisbroth SH, Peress N. Ophthalmic lesions and dacryoadenitis: a naturally occurring aspect of sialodacryoadenitis virus infection of the laboratory rat. Lab Anim Sci. 1977;27(4):466–73.
Percy DH, et al. Comparison of strain susceptibility to experimental sialodacryoadenitis in rats. Lab Anim Sci. 1984;34(3):255–60.
Percy DH, Wojcinski ZW, Schunk MK. Sequential changes in the harderian and exorbital lacrimal glands in Wistar rats infected with sialodacryoadenitis virus. Vet Pathol. 1989;26(3):238–45.
Burling K, et al. Anatomy of the rabbit nasolacrimal duct and its clinical implications. Vet Comp Ophthalmol. 1991;1(1):33–40.
For Additional Information of the SEND and INHAND Initiatives, Please See These Additional Resources:
Acknowledgments
The authors wish to thank Drs. David Wilkie, Roy Bellhorn, and Randy Sharp for generously providing images, Dr. Craig Zwickle (Chair SEND CT) for a detail discussion regarding the SEND terminology approval process, and Dr. John Vahle (Member INHAND GESC) for providing a historical perspective of the INHAND effort.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Bartoe, J.T., Cook, C.S., Bussieres, M., Munger, R.J., Brown, M.H. (2018). Harmonization of Lesion Nomenclature in Laboratory Animals. In: Gilger, B., Cook, C., Brown, M. (eds) Standards for Ocular Toxicology and Inflammation. Springer, Cham. https://doi.org/10.1007/978-3-319-78364-2_3
Download citation
DOI: https://doi.org/10.1007/978-3-319-78364-2_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-78363-5
Online ISBN: 978-3-319-78364-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)