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Innovations for Next-Generation Antibody-Drug Conjugates pp 299–319Cite as

Antibody-Drug Conjugates: Targeting the Tumor Microenvironment

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Antibody-drug conjugates (ADCs) have been used for more than two decades as tools for the selective delivery of cytotoxic agents to the tumor site, with the aim to increase anti-cancer activity and spare normal tissues from undesired toxicity. Until recently, most ADC development activities have focused on the use of monoclonal antibodies, capable of selective binding and internalization into the target tumor cells. However, in principle, it would be conceivable to develop non-internalizing ADC products, which liberate their toxic payload in the extracellular environment. In this Chapter, we review previous work performed on non-internalizing ADC products, with a special emphasis on drug conjugates which selectively localize to the modified extracellular matrix in the neoplastic mass.

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  1. Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland

    Alberto Dal Corso, Samuele Cazzamalli & Dario Neri

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  1. Alberto Dal Corso
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  2. Samuele Cazzamalli
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  3. Dario Neri
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Correspondence to Dario Neri .

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  1. Mersana Therapeutics, Inc., Cambridge, Massachusetts, USA

    Marc Damelin

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Dal Corso, A., Cazzamalli, S., Neri, D. (2018). Antibody-Drug Conjugates: Targeting the Tumor Microenvironment. In: Damelin, M. (eds) Innovations for Next-Generation Antibody-Drug Conjugates. Cancer Drug Discovery and Development. Humana Press, Cham. https://doi.org/10.1007/978-3-319-78154-9_13

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  • DOI: https://doi.org/10.1007/978-3-319-78154-9_13

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-78153-2

  • Online ISBN: 978-3-319-78154-9

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