Abstract
When in the early 1980s of the last century, Dr. Etienne-Emile Baulieu synthesized the first in the history—antiprogesterone—RU 486 or mifepristone, everybody considered it to be an “abortion pill” only. Beyond any doubt, it was a great achievement too, but the life has showed later that the new compound has not only this possibility but also the potential for solution of all problems, when progesterone is not needed.
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References
von Hertzen H, et al. Lancet. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomized trial. 2002;360(9348):1803–10.
Trussell J, Raymond E, Cleland K. Emergency contraception: a last chance to prevent unwanted pregnancy. Princeton: Princeton University; 2016.
Wertheimer R. Emergency postcoital contraception. Am FamPhysician. 2000;62(10):2287–92.
Sarkar NN. The potential of mifepristone (RU-486) as an emergency contraceptive drug. Acta Obstet Gynecol Scand. 2005;84(4):306–16.
Finer LB, Zolna MR. Declines in unintended pregnancy in the United States, 2008-2011. N Engl J Med. 2016;374:843–52.
Li HWR, Lo SST, Ng EHY, Ho PC. Efficacy of ulipristal acetate for emergency contraception and its effect on the subsequent bleeding pattern when administered before or after ovulation. Hum Reprod. 2016;31:1200–7.
Cheng L, Che Y, Gülmezglu AM. Interventions for emergency contraception. Cochrane Database Sys Rev. 2012;(8):CD001324.
Turok DT, Sanders JN, Thompson IS, Royer PA, Eggebroten J, Gawron L. Preference for and efficacy of oral levonorgestrel for emergency contraception with concomitant placement of a levonorgestrel IUD: a prospective cohort study. Contraception. 2016;93:526–32.
Kapp N, Abitbol JL, Mathé H, Scherrer B, Guilard H, Gainer E, Ulmann A. Effect of body weight and BMI on the efficacy of levonorgestrel emergency contraception. Contraception. 2015;91(2):97–104.
United States Food and Drug Administration. FDA communication on levonorgestrel emergency contraceptive effectiveness and weight. Available at: http://www.fda.gov/Drugs/DrugsSafety/PostmarketDrugSafetyinformationforPatientaandProviders/ucm109775.htm. Accessed 24 May 2016.
Berger C, Boggavarapu NR, Menezes J, Lalitkumar PG, Gemzell-Danielson K. Effects of ulipristal acetate on human embryo attachment and endometrial cell gene expression in an in vitro co-culture system. Hum Reprod. 2015;30:800–11.
Jasam C, Cochon L, Salvatierra AM, Williams A, Kapp N, Levy-Gompel D, Brache VA. prospective, open-label, multicenter study to assess the pharmacodynamics and safety of repeated use of 30 mg ulipristal acetate. Contraception. 2016;93:310–6.
Jatlaoui TV, Riley H, Curtis KM. Safety data for levonorgestrel, ulipristal acetate and Yuzpe regimens for emergency contraception. Contraception. 2016;93:93–212.
Cameron ST, Berger C, Michie L, Klipping C, Gemzell-Danielsson K. The effects on ovarian activity of ulipristal acetate when ‘quickstarting’ a combined oral contraceptive pill: a prospective, randomized, double-blind parallel-arm, placebo-controlled study. Hum Reprod. 2015;30:1566–73.
Cintia L, Johansen MS. The effect of plan B on teen abortions: evidence from the 2006 FDA ruling. Contemp Econ Policy. 2015;33:418–33.
Bullock H, Steele S, Kurata N, et al. Pharmacy access to ulipristal acetate in Hawaii: is a prescription enough? Contraception. 2015;92:388–9.
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© 2018 IAHR (International Academy of Human Reproduction)
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Khomasuridze, A. (2018). Mifepristone for Postcoital Contraception. In: Schenker, J., Sciarra, J., Mettler, L., Genazzani, A., Birkhaeuser, M. (eds) Reproductive Medicine for Clinical Practice. Reproductive Medicine for Clinicians, vol 1. Springer, Cham. https://doi.org/10.1007/978-3-319-78009-2_12
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DOI: https://doi.org/10.1007/978-3-319-78009-2_12
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