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Hypothermia

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Forensic Histopathology
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Abstract

Fatalities due to hypothermia occur primarily, but not exclusively, during the cold season and produce findings that can also be identified histopathologically, such as Wischnewski spots in the gastric mucosa. Other findings that form during the hypothermic process are only frequent on microscopy but cannot always be demonstrated, e.g., fat vacuoles in the renal tubular epithelial cells, as well as in the cytoplasm of cardiomyocytes; in the case of the latter, however, it is important to distinguish between fat vacuoles and lipofuscin deposits. Hypothermia-related microthrombi in internal organs, primarily evident in peripheral vascular branches of the mesenteric vessels, can only be detected using microscopy, much like microhemorrhages in pancreatic tissue. Findings of this kind, however, can yield important, indeed compelling information pointing to death due to hypothermia. Intracytoplasmic vacuoles in the pancreatic epithelium have also been described in hypothermia deaths, as has a level of colloid depletion within the thyroid follicles, even though the validity of these findings is controversial in some cases.

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References

  • Armbrust S, Nikischin W, Rochholz G, Franzelius C, Bielstein A, Kramer HH (2010) Hypothermia in a combined intoxication with doxepin and moclobemide in an adolescent. Forensic Sci Int 195:e1–e3

    Article  CAS  PubMed  Google Scholar 

  • BaÅ„ka K, TeresiÅ„ski G, Buszewicz G (2014) Free fatty acids as markers of death from hypothermia. Forensic Sci Int 234:79–85

    Article  CAS  PubMed  Google Scholar 

  • BaÅ„ka K, TeresiÅ„ski G, Buszewicz G, MÄ…dro R (2013) Glucocorticosteroids as markers of death from hypothermia. Forensic Sci Int 229:60–65

    Article  CAS  PubMed  Google Scholar 

  • Berger RL (1990) Nazi science – the Dachau hypothermia experiments. N Engl J Med 322:1435–1440

    Article  CAS  PubMed  Google Scholar 

  • Birchmeyer MS, Mitchell EK (1989) Wischnewski revisited: the diagnostic value of gastric mucosa ulcers in hypothermic deaths. Am J Forensic Med Pathol 10:28–30

    Article  CAS  PubMed  Google Scholar 

  • Bockholdt B, Maxeiner H, Müllter S (2004) Death due to hypothermia in the city of berlin: circumstances, post mortem findings, specific features. In: Oehmichen M (ed) Hypothermia. Clinical, pathomorphological and forensic features. Research in legal medicine, vol 31. Schmidt-Römhild, Lübeck, pp 85–103

    Google Scholar 

  • Bourne MH, Piepkorn MW, Clayton F, Leonard LG (1986) Analysis of microvascular changes in frostbite injury. J Surg Res 40:26–35

    Article  CAS  PubMed  Google Scholar 

  • Brendel W, Müller C, Messmer K, Reulen HJ (1968) Der klinische Tod in Hypothermie. Z Gesamte Exp Med 146:189–205

    Article  CAS  PubMed  Google Scholar 

  • Bright F, Winskog C, Byard RW (2013) Wischnewski spots and hypothermia: sensitive, specific, or serendipitous? Forensic Sci Med Pathol 9:88–90

    Article  PubMed  Google Scholar 

  • Büchner F (1943) Die Pathologie der Unterkühlung. Klin Wochenschr 22:89–92

    Article  Google Scholar 

  • Cali JR, Glaubitz JP, Crampton RS (1965) Gastric necrosis due to prolonged local gastric hypothermia. JAMA 191:154–155

    Article  Google Scholar 

  • Coe JL (1984) Hypothermia: autopsy findings and vitreous glucose. J Forensic Sci 29:289–395

    Article  Google Scholar 

  • Coniam WS (1979) Accidental hypothermia. Anaesthesia 34:250–256

    Article  CAS  PubMed  Google Scholar 

  • Danzl DF, Pozos RS (1994) Accidental hypothermia. N Engl J Med 331:1756–1760

    Article  CAS  PubMed  Google Scholar 

  • Duguid H, Simpson G, Stowers J (1961) Accidental hypothermia. Lancet 2:1213–1219

    Article  CAS  PubMed  Google Scholar 

  • Eckart WU, Vondra H (2004) Disregard for human life: hypothermia experiments in the Dachau concentration camp. In: Oehmichen M (ed) Hypothermia. Clinical, pathomorphological and forensic features. Research in legal medicine, vol 31. Schmidt-Römhild, Lübeck, pp 19–31

    Google Scholar 

  • Ehrlich E (2004) Wischnewski’s spots. A new sign of death from hypothermia. The translated text of the original Russian article from 1885. In: Oehmichen M (ed) Hypothermia. Clinical, pathomorphological and forensic features, research in legal medicine, vol 31. Schmidt-Römhild, Lübeck, pp 205–210

    Google Scholar 

  • Elshama SS, Osman HEH, El-Kenawy AEM (2016) Postmortem diagnosis of induced fatal hypothermia in adult albino rats. Rom J Leg Med 24:106–114

    Google Scholar 

  • Emslie-Smith D (1958) Accidental hypothermia. Lancet 2:492–495

    Article  CAS  PubMed  Google Scholar 

  • Fisher ER, Fedor EJ, Fisher B (1957) Pathologic and histochemical observations in experimental hypothermia. AMA Arch Surg 75:817–827

    Article  CAS  PubMed  Google Scholar 

  • Hirvonen J (1976) Necropsy findings in fatal hypothermia cases. Forensic Sci 8:155–164

    Article  CAS  PubMed  Google Scholar 

  • Hirvonen J (1977) Systemic and local effects of hypothermia. In: Tedeschi CG, Eckert WG, Tedeschi LG (eds) Forensic medicine, vol 1. Saunders Company, Philadelphia, pp 758–774

    Google Scholar 

  • Hirvonen J, Elfving R (1974) Histamine and serotonin in the gastric erosions of rats dead from exposure to cold: a histochemical and quantitative study. Z Rechtsmed 74:273–281

    Article  CAS  PubMed  Google Scholar 

  • Ishikawa T, Miyaishi S, Tachibana T, Ishizu H, Zhu BL, Maeda H (2004) Fatal hypothermia related vacuolation of hormone-producing cells in the anterior pituitary. Legal Med 6:157–163

    Article  CAS  PubMed  Google Scholar 

  • Ishikawa T, Quan L, Li DR, Zhao D, Michiue T, Hamel M, Maeda H (2008) Postmortem biochemistry and immunohistochemistry of adrenocorticotropic hormone with special regard to fatal hypothermia. Forensic Sci Int 179:147–151

    Article  CAS  PubMed  Google Scholar 

  • Kitamura O, Gotohda T, Ishigami A, Tokunaga I, Kubo S, Nakasono I (2005) Effect of hypothermia on postmortem alterations in MAP 2 immunostaining in the human hippocampus. Legal Med 7:24–30

    Article  CAS  PubMed  Google Scholar 

  • Mant AK (1964) Some post-mortem observations in accidental hypothermia. Med Sci Law 4(1):44–46

    Article  CAS  PubMed  Google Scholar 

  • Mant AK (1967) The pathology of hypothermia. In: Simpson K (ed) Modern trends in forensic medicine, vol 2. Butterworths, London, pp 224–232

    Google Scholar 

  • Mant AK, Path FC (1969) Autopsy diagnosis of accidental hypothermia. J Forensic Med 16:126–129

    PubMed  CAS  Google Scholar 

  • Mizukami H, Shimizu K, Shiono H, Uezono T, Sasaki M (1999) Forensic diagnosis of death from cold. Legal Med 1:204–209

    Article  CAS  PubMed  Google Scholar 

  • Müller E, Rotter W, Carow G, Kloos KF (1943) Ãœber Untersuchungsergebnisse bei Todesfällen nach allgemeiner Unterkühlung des Menschen in Seenot. Beitr Pathol Anat 108:552–589

    Google Scholar 

  • Oehmichen M (2004) Hypothermia. Clinical, pathomorphological and forensic features. Research in legal medicine, vol 31. Schmidt-Römhild, Lübeck

    Google Scholar 

  • Palmiere C, Bardy D, Letovanec I, Mangin P, Augsburger M, Ventura F, Iglesias K, Werner D (2013) Biochemical markers of fatal hypothermia. Forensic Sci Int 226:54–61

    Article  CAS  PubMed  Google Scholar 

  • Parai JL, Kodikara S, Milroy C, Pollanen MS (2012) Alcoholism and the Armanni-Ebstein lesion. Forensic Sci Med Pathol 8:19–22

    Article  PubMed  Google Scholar 

  • Pavlic M, Grubwieser P, Rabl W (2004) Death in snow avalanches: hypoxia – blunt trauma – hypothermia. In: Oehmichen M (ed) Hypothermia. Clinical, pathomorphological and forensic features. Research in legal medicine, vol 31. Schmidt-Römhild, Lübeck, pp 141–152

    Google Scholar 

  • Preuß J, Dettmeyer R, Lignitz E, Madea B (2004) Fatty degeneration in renal tubule epithelium in accidental hypothermia victims. Forensic Sci Int 141:131–135

    Article  CAS  PubMed  Google Scholar 

  • Preuß J, Dettmeyer R, Lignitz E, Madea B (2006) Fatty degeneration of myocardial cells as a sign of death due to hypothermia versus degenerative deposition of lipofuscin. Forensic Sci Int 159:1–5

    Article  CAS  PubMed  Google Scholar 

  • Preuß J, Thierauf A, Dettmeyer R, Madea B (2007a) Wischnewski’s spot in an ectopic stomach. Forensic Sci Int 169:220–222

    Article  PubMed  Google Scholar 

  • Preuß J, Lignitz E, Dettmeyer R, Madea B (2007b) Pancreatic changes in cases of death due to hypothermia. Forensic Sci Int 166:194–198

    Article  PubMed  Google Scholar 

  • Preuß J, Dettmeyer R, Poster S, Lignitz E, Madea B (2008) The expression of heat shock protein 70 in kidneys in cases of death due to hypothermia. Forensic Sci Int 176:248–252

    Article  CAS  PubMed  Google Scholar 

  • Read AE, Emslie-Smith D, Gough KR, Holmes R (1961) Pancreatitis and accidental hypothermia. Lancet 2:1219–1221

    Article  CAS  PubMed  Google Scholar 

  • Sano ME, Smith CW (1940) Fifty post-mortem patients with cancer subjected to local or generalized refrigeration. J Lab Clin Med 26:443

    Google Scholar 

  • Shimizu K, Ohtani S, Shiono H, Fukusima T, Sasaki M (1997) Expression of ubiquitin protein in each organ at death from hypothermia. Forensic Sci Int 86:61–68

    Article  CAS  PubMed  Google Scholar 

  • Sperhake JP, Rothschild MA, Riße M, Tsokos M (2004) Histomorphology of Wischnewski’s spots: a contribution to the forensic histopathology of fatal hypothermia. In: Oehmichen M (ed) Hypothermia. Clinical, pathomorphological and forensic features. Research in legal medicine, vol 31. Schmidt-Römhild, Lübeck, pp 211–220

    Google Scholar 

  • Stoddard JC (1962) Mesenteric infarction during hypothermia. Br J Anaesth 34:825–830

    Article  Google Scholar 

  • Takada M, Kusano I, Yamamoto H, Shiraishi T, Yatani R, Haba K (1991) Wischnewski’s gastric lesions in accidental hypothermia. Am J Forensic Med Pathol 12:300–305

    Article  CAS  PubMed  Google Scholar 

  • Thrun C (1992) Verfettung der Tubulusepithelien der Niere – ein Hinweis für Hypothermie? Rechtsmedizin 2:55–58

    Google Scholar 

  • Tidow R (1943) Kälteschäden des Magendarmkanals unter besonderer Berücksichtigung der Abkühlung. Münch Med Wochenschr 90:597–600

    Google Scholar 

  • Tsokos M, Rothschild MA, Madea B, Rie M, Sperhake JP (2006) Histological and immunohistochemical study of Wischnewski spots in fatal hypothermia. Am J Forensic Med Pathol 27:70–74

    Article  PubMed  Google Scholar 

  • Türk EE, Sperhake JP, Pueschel K, Tsokos M (2005) An approach to the evaluation of fatal hypothermia. Forensic Sci Med Pathol 1:31–35

    Article  PubMed  Google Scholar 

  • Türk EE, Sperhake JP, Madea B, Preuß J, Tsokos M (2006) Immunohistochemical detection of hemoglobin in frost erythema. Forensic Sci Int 158:131–134

    Article  CAS  PubMed  Google Scholar 

  • Wischnewski SM (1895) Neues Merkmal des Todes bei Unterkühlung. Informationsblatt der Hygiene, gerichtliche und praktische Medizin 3:11–20

    Google Scholar 

  • Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H (2013) Molecular pathology of pulmonary edema in forensic autopsy cases with special regard to fatal hyperthermia and hypothermia. Forensic Sci Int 228:137–141

    Article  CAS  PubMed  Google Scholar 

  • Wolf DA, Aronson JF, Rajaraman S, Veasey SP (1999) Wischnewski ulcers and acute pancreatitis in two hospitalized patients with cirrhosis, portal vein thrombosis, and hypothermia. J Forensic Sci 44:1082–1085

    Article  CAS  PubMed  Google Scholar 

  • Yoshida C, Ishikawa T, Michiue T, Quan L, Madea H (2011) Postmortem biochemistry and immunohistochemistry of chromogranin a as a stress marker with special regard to fatal hypothermia and hyperthermia. Int J Legal Med 125:11–20

    Article  PubMed  Google Scholar 

  • Zhou C, Byard RW (2011) Armanni-Ebstein phenomenon and hypothermia. Forensic Sci Int 206:e82–e84

    Article  PubMed  Google Scholar 

  • Živković V, Nikolić S (2013) The unusual appearance of black esophagus in a case of fatal hypothermia: a possible underlying mechanism. Forensic Sci Med Pathol 9:613–514

    Article  PubMed  Google Scholar 

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Dettmeyer, R.B. (2018). Hypothermia. In: Forensic Histopathology. Springer, Cham. https://doi.org/10.1007/978-3-319-77997-3_8

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  • DOI: https://doi.org/10.1007/978-3-319-77997-3_8

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