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Heart Transplantation Survival and Sex-Related Differences

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Book cover Sex-Specific Analysis of Cardiovascular Function

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1065))

Abstract

Orthotopic heart transplantation (OHT) is the “gold standard” treatment for patients with end-stage heart failure, with approximately 5000 transplants performed each year worldwide. Heart transplantation survival rates have progressively improved at all time points, despite an increase in donor and recipient age and comorbidity and greater recipient urgency; according to the registry of the International Society of Heart and Lung Transplantation (ISHLT), the median survival of patients posttransplantation is currently 12.2 years.

Long-term survival is sub-optimal, and outcomes after OHT remain constrained by the development of acute rejection and cardiac allograft vasculopathy (CAV). Moreover, donor organs are in short supply, making optimal organ utilization an ongoing priority. For these reasons, substantial interest continues to exist in identifying factors portending increased survival and improved organ utilization.

Heart transplant recipient George DeBord holds his own heart aloft (1968). Art work by Piet Michiels, Leuven, Belgium.

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Author information

Authors and Affiliations

  1. Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy

    Martina Previato & Francesco Tona

  2. Laboratory of Translational Nutrition Biology, Federal Institute of Technology Zurich ETHZ, Zurich, Switzerland

    Elena Osto

  3. Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland

    Elena Osto

  4. University Heart Center, Cardiology, University Hospital Zurich, Zurich, Switzerland

    Elena Osto

  5. Department of Radiology and Nuclear Medicine, Amsterdam Cardiovascular Sciences, VU University Medical Center, Amsterdam, The Netherlands

    Peter L. M. Kerkhof

  6. Department of Cardiopulmonary Transplantation, Freeman Hospital, Newcastle upon Tyne, UK

    Gareth Parry

Authors
  1. Martina Previato
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  2. Elena Osto
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  3. Peter L. M. Kerkhof
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  4. Gareth Parry
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  5. Francesco Tona
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Corresponding authors

Correspondence to Elena Osto or Francesco Tona .

Editor information

Editors and Affiliations

  1. Department of Radiology and Nuclear Medicine, Amsterdam Cardiovascular Sciences, VU University Medical Center, Amsterdam, The Netherlands

    Peter L. M. Kerkhof

  2. Mayo Clinic, Rochester, Minnesota, USA

    Virginia M. Miller

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Previato, M., Osto, E., Kerkhof, P.L.M., Parry, G., Tona, F. (2018). Heart Transplantation Survival and Sex-Related Differences. In: Kerkhof, P., Miller, V. (eds) Sex-Specific Analysis of Cardiovascular Function. Advances in Experimental Medicine and Biology, vol 1065. Springer, Cham. https://doi.org/10.1007/978-3-319-77932-4_24

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