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The Heterogeneity of Cancer Metabolism pp 149–165Cite as

Metabolic Relationship between Cancer-Associated Fibroblasts and Cancer Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1063))

Abstract

Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME), play an important role in cancer initiation, progression, and metastasis. Recent findings have demonstrated that the TME not only provides physical support for cancer cells, but also directs cell-to-cell interactions (in this case the interaction between cancer cells and CAFs). As cancer progresses, the CAFs also co evolve—transitioning from an inactivated state to an activated state. The elucidation and understanding of the interaction between cancer cells and CAFs will pave the way for new cancer therapies [1–3].

The TME is a heterogeneous environment consisting of fibroblasts, tumor-associated macrophages, adipocytes, an extracellular matrix, and mesenchymal stem cells [4]. The exact composition of each stroma varies depending on cancer and tissue type. To add to this variation, there is heterogeneity even within the CAF population itself. Different CAFs express different markers and influence stromal pro-tumorigenic capacity and cancer progression in diverse ways [5, 6].

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Abbreviations

α-SMA:

α-Smooth muscle actin

CAF:

Cancer-associated fibroblast

Cav-1:

Caveolin -1

CDE:

CAF-derived exosomes

EMT:

Epithelial-mesenchymal transition

FASN:

Fatty acid synthase

FH:

Fumarase

HIF-1:

Hypoxia-inducible factor-1

LDHA:

Lactate dehydrogenase A

MCT:

Monocarboxylate transporter

NF:

Normal fibroblasts

PDAC:

Pancreatic ductal adenocarcinoma

PKM2:

Pyruvate kinase isozymes M1/M2

PSC:

Pancreatic stellate cells

ROS:

Reactive oxygen species

SDH:

Succinate dehydrogenase

TCA:

Tricarboxylic acid

TGF-β:

Transforming growth factor beta

TME:

Tumor microenvironment

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Author information

Authors and Affiliations

  1. Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

    Christos Sazeides

  2. Department of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Anne Le

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  1. Christos Sazeides
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  2. Anne Le
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Correspondence to Anne Le .

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Editors and Affiliations

  1. Johns Hopkins Medicine, Baltimore, MD, USA

    Anne Le MD, HDR

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Sazeides, C., Le, A. (2018). Metabolic Relationship between Cancer-Associated Fibroblasts and Cancer Cells. In: Le, A. (eds) The Heterogeneity of Cancer Metabolism. Advances in Experimental Medicine and Biology, vol 1063. Springer, Cham. https://doi.org/10.1007/978-3-319-77736-8_11

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