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Carbohydrate Modifiers for Tissue Engineering Scaffolds

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Carbohydrate-Based Interactions at the Molecular and the Cellular Level

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Abstract

Three monosaccharides, Glc (23), Gal (24), and GlcNAc (25, Fig. 1.2) were selected as initial targets for the synthesis of carbohydrate modifiers for the hSAF scaffold. These were chosen due to their prevalence in biology as some of the major components of natural oligosaccharides (Werz et al., ACS Chem Biol 2:685–691, 2007, [1]), meaning that they are most likely to be tolerated by cells and elicit a biological response. Their ubiquity also means that they are readily available and accessible syntheses of many derivatives have been developed.

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Notes

  1. 1.

    See Abbreviations and Acronyms for full explanation of this notation.

  2. 2.

    See Sect. 5.6.1 for details of the synthesis of the linker used.

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Authors and Affiliations

  1. Department of Chemistry, University of British Columbia, Vancouver, BC, Canada

    Kieran L. Hudson

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  1. Kieran L. Hudson
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Correspondence to Kieran L. Hudson .

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Hudson, K.L. (2018). Carbohydrate Modifiers for Tissue Engineering Scaffolds. In: Carbohydrate-Based Interactions at the Molecular and the Cellular Level. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-77706-1_5

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