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Apoptosis-Inducing Factor Translocation to Nuclei After Transient Global Ischemia

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Acute Neuronal Injury

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Abstract

As a common human disorder, global ischemia causes long-term cognitive dysfunction. Selective death of hippocampal CA1 neurons underlies the cognitive impairment. After global ischemia, CA1 neuronal death occurs in a delayed manner, suggesting a type of programmed cell death. Apoptosis-inducing factor (AIF) is a mitochondrial protein with an important role in energy metabolism under physiological conditions. Following ischemia, AIF leaves mitochondria, translocates into nuclei, and induces DNA cleavage and chromatin condensation, therefore playing critical roles in inducing caspase-independent programmed cell death. In this chapter, we summarize the roles of AIF in CA1 nearonal death following global ischemia, highlighting recent progress.

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Authors and Affiliations

  1. Department of Neurology, Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh, Pittsburgh, PA, USA

    Yang Sun, Tuo Yang, Jessica Zhang, Armando P. Signore, Guodong Cao, Jun Chen & Feng Zhang

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  1. Yang Sun
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  2. Tuo Yang
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  3. Jessica Zhang
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  4. Armando P. Signore
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  5. Guodong Cao
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  6. Jun Chen
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  7. Feng Zhang
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Corresponding authors

Correspondence to Jun Chen or Feng Zhang .

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Editors and Affiliations

  1. Department of Neurology, VA Greater Los Angeles Healthcare System, North Hills, California, USA

    Denson G. Fujikawa

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Sun, Y. et al. (2018). Apoptosis-Inducing Factor Translocation to Nuclei After Transient Global Ischemia. In: Fujikawa, D. (eds) Acute Neuronal Injury. Springer, Cham. https://doi.org/10.1007/978-3-319-77495-4_7

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