Abstract
In the last decades, the surgical treatment of meniscal injury or damage has shifted from a total meniscectomy to a partial meniscectomy or repair. Rather than a removal of meniscal tissue, the goal of novel surgical techniques is to preserve as much functional meniscal tissue as possible. Recently, attempts have been made to promote meniscal healing, as well as the replacement of damaged menisci with allografts, scaffolds, meniscal implants, or substitutes. This chapter will focus on meniscal augmentation and on three types of meniscal replacement devices. These substitutes are the biological Menaflex™ or collagen meniscal implant (CMI), the biomimetic Actifit™ meniscal scaffold, and the nonbiological NUsurface® meniscal substitute.
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References
Arnoczky SP, Warren RF. Microvasculature of the human meniscus. Am J Sports Med. 1982;10:90–5.
Maak TG, Fabricant PD, Wickiewicz TL. Indications for meniscus repair. Clin Sports Med. 2012;31:1–14.
Moran CJ, Busilacchi A, Lee CA, Athanasiou KA, Verdonk PC. Biological augmentation and tissue engineering approaches in meniscus surgery. Arthroscopy. 2015;31:944–55.
Scotti C, Hirschmann MT, Antinolfi P, Martin I, Peretti GM. Meniscus repair and regeneration: review on current methods and research potential. Eur Cell Mater. 2013;26:150–70.
Jang SH, Ha JK, Lee DW, Kim JG. Fibrin clot delivery system for meniscal repair. Knee Surg Relat Res. 2011;23:180–3.
Ra HJ, Ha JK, Jang SH, Lee DW, Kim JG. Arthroscopic inside-out repair of complete radial tears of the meniscus with a fibrin clot. Knee Surg Sports Traumatol Arthrosc. 2013;21:2126–30.
Vangsness CT Jr, Farr J II, Boyd J, Dellaero DT, Mills CR, Leroux-Williams M. Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study. J Bone Joint Surg Am. 2014;96:90–8.
Stone KR, Rodkey WG, Webber R, et al. Meniscal regeneration with co polymeric collagen scaffolds. In vitro and in vivo studies evaluated clinically, histologically, and biochemically. Am J Sports Med. 1992;20:104–11.
Rodkey WG, Steadman JR, Li ST. A clinical study of collagen meniscus implants to restore the injured meniscus. Clin Orthop Relat Res. 1999;367:281–92.
Stone KR, Steadman JR, Rodkey WG, et al. Regeneration of meniscal cartilage with use of a collagen scaffold. Analysis of preliminary data. J Bone Joint Surg Am. 1997;79:1770–7.
Zaffagnini S, Marcheggiani Muccioli GM, Lopomo N, et al. Prospective long-term outcomes of the medial collagen meniscus implant versus partial medial meniscectomy: a minimum 10-year follow-up study. Am J Sports Med. 2011;39:977–85.
Tienen TG, Heijkants RG, de GJH, et al. Replacement of the knee meniscus by a porous polymer implant: a study in dogs. Am J Sports Med. 2006;34:64–71.
Verdonk P, Verdonk R, Huysse W, et al. Successful treatment of painful irreparable partial meniscal defects with a polyurethane scaffold—two year safety and clinical outcomes. Am J Sports Med. 2012;40:844–53.
Verdonk R, Verdonk P, Huysse W, et al. Tissue ingrowth after implantation of a novel, biodegradable polyurethane scaffold for treatment of partial meniscal lesions. Am J Sports Med. 2011;39:774–82.
Dhollander A, Verdonk P, Verdonk R. Treatment of painful, irreparable partial meniscal defects with a polyurethane scaffold: midterm clinical outcomes and survival analysis. Am J Sports Med. 2016;44:2615–21.
Zorzi C, Condello V, Verdonk P, et al. Too old for regenerative treatment? Too young for joint replacement? Clinical indication for a novel meniscus implant. ICRS 2012 meeting, Montreal, Canada, 12–15 May 2012.
Elsner JJ, Portnoy S, Guilak F, Shterling A, Linder-Ganz E. MRI-based characterization of bone anatomy in the human knee for size matching of a medialmeniscal implant. J Biomech Eng. 2010;132:101008.
Linder-Ganz E, Elsner JJ, Danino A, Guilak F, Shterling A. A novel quantitative approach for evaluating contact mechanics of meniscal replacements. J Biomech Eng. 2010;132:024501.
Elsner JJ, Shemesh M, Shefy-Peleg A, Gabet Y, Zylberberg E, Linder-Ganz E. Quantification of in vitro wear of a synthetic meniscus implant using gravimetric and micro-CT measurements. J Mech Behav Biomed Mater. 2015;49:310–20.
Elsner JJ, Portnoy S, Zur G, Guilak F, Shterling A, Linder-Ganz E. Design of a free-floating polycarbonate-urethane meniscal implant using finite element modeling and experimental validation. J Biomech Eng. 2010;132:095001.
Zur G, Linder-Ganz E, Elsner JJ, Shani J, Brenner O, Agar G, Hershman EB, Arnoczky SP, Guilak F, Shterling A. Chondroprotective effects of a polycarbonate-urethane meniscal implant: histopathological results in a sheep model. Knee Surg Sports Traumatol Arthrosc. 2011;19:255–63.
Shemesh M, Asher R, Zylberberg E, Guilak F, Linder-Ganz E, Elsner JJ. Viscoelastic properties of a synthetic meniscus implant. J Mech Behav Biomed Mater. 2014;29:42–55.
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Dhollander, A.A.M., Condello, V., Madonna, V., Bonomo, M., Verdonk, P. (2018). Meniscal Augmentation and Replacement (Menaflex, Actifit, and NUsurface). In: Farr, J., Gomoll, A. (eds) Cartilage Restoration. Springer, Cham. https://doi.org/10.1007/978-3-319-77152-6_28
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DOI: https://doi.org/10.1007/978-3-319-77152-6_28
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