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Management of Thrombotic Microangiopathies in Pregnancy

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Transfusion Management of the Obstetrical Patient

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Abstract

Thrombotic microangiopathy (TMA) may occur with pregnancy in the setting of several conditions including severe preeclampsia with HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome, TTP (thrombotic thrombocytopenic purpura), and HUS (hemolytic uremic syndrome), predominantly in the form of atypical HUS (aHUS). Formation of microthrombi in the microcirculation is a pathological finding common to these disorders, resulting in overlapping clinical presentations. However, certain clinical and laboratory features may facilitate differential diagnosis among these conditions, and provision of appropriate therapy may be dependent upon establishing the underlying cause of TMA.

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Author information

Authors and Affiliations

  1. Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN, USA

    Jeffrey L. Winters M.D. & Kristina A. Davis M.D.

  2. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA

    Vesna D. Garovic M.D.

  3. Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA

    Layana Alrahmani M.D.

Authors
  1. Jeffrey L. Winters M.D.
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  2. Vesna D. Garovic M.D.
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  3. Layana Alrahmani M.D.
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  4. Kristina A. Davis M.D.
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Corresponding author

Correspondence to Kristina A. Davis M.D. .

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Editors and Affiliations

  1. University of Washington Medical Center, Bloodworks Northwest, Seattle, Washington, USA

    Theresa Nester

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Winters, J.L., Garovic, V.D., Alrahmani, L., Davis, K.A. (2018). Management of Thrombotic Microangiopathies in Pregnancy. In: Nester, T. (eds) Transfusion Management of the Obstetrical Patient. Springer, Cham. https://doi.org/10.1007/978-3-319-77140-3_16

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  • DOI: https://doi.org/10.1007/978-3-319-77140-3_16

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