Abstract
Bone marrow (BM)-based diagnosis of hematologic disorders, in particular lymphoid and myeloid neoplasms, is complex and requires a multidisciplinary, multivalued, and integrative approach that includes morphologic (cytologic and histologic), cytogenetic, and molecular genetic findings and immunophenotyping (flow cytometry and immunohistochemistry). The morphological assessment is based on both the cytology of a bone marrow smear and the histology of a bone marrow trephine biopsy which complement each other.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Hasserjian RP, Head DR. Myelodysplastic syndromes. In: Jaffe E, Arber D, Campo E, Harrys M, Quintanilla-Martinez L, editors. Hematopathology. 2nd ed. Philadelphia: Elsevier; 2017.
Valent P, Orazi A, Busche G, et al. Standards and impact of hematopathology in myelodysplastic syndromes (MDS). Oncotarget. 2010;1:483–96.
Lambertenghi-Deliliers G, Orazi A, Luksch R, Annaloro C, Soligo D. Myelodysplastic syndrome with increased marrow fibrosis: a distinct clinico-pathological entity. Br J Haematol. 1991;78:161–6.
Fu B, Jaso JM, Sargent RL, et al. Bone marrow fibrosis in patients with primary myelodysplastic syndromes has prognostic value using current therapies and new risk stratification systems. Mod Pathol. 2013;27:681–9.
Saft L, Karimi M, Ghaderi M, Matolcsy A, Mufti GJ, Kulasekararaj A, Göhring G, Giagounidis A, Selleslag D, Muus P, Sanz G, Mittelman M, Bowen D, Porwit A, Fu T, Backstrom J, Fenaux P, MacBeth KJ, Hellström-Lindberg E. p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q). Haematologica. 2014;99(6):1041–9.
Buesche G, Teoman H, Wilczak W, Ganser A, Hecker H, Wilkens L, Göhring G, Schlegelberger B, Bock O, Georgii A, Kreipe H. Marrow fibrosis predicts early fatal marrow failure in patients with myelodysplastic syndromes. Leukemia. 2008;22(2):313–22.
Della Porta MG, Malcovati L, Boveri E, Travaglino E, Pietra D, Pascutto C, Passamonti F, Invernizzi R, Castello A, Magrini U, Lazzarino M, Cazzola M. Clinical relevance of bone marrow fibrosis and CD34-positive cell clusters in primary myelodysplastic syndromes. J Clin Oncol. 2009;27(5):754–62.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Dirnhofer, S. (2018). Histology. In: Platzbecker, U., Fenaux, P. (eds) Myelodysplastic Syndromes . Hematologic Malignancies. Springer, Cham. https://doi.org/10.1007/978-3-319-76879-3_3
Download citation
DOI: https://doi.org/10.1007/978-3-319-76879-3_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-76878-6
Online ISBN: 978-3-319-76879-3
eBook Packages: MedicineMedicine (R0)