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Morphology and Flow Cytometry

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Myelodysplastic Syndromes

Part of the book series: Hematologic Malignancies ((HEMATOLOGIC))

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Abstract

Despite the rapid development of molecular markers during the last years, the morphology of blood and bone marrow cells still keeps the crucial role for diagnosis and subclassification of the different subtypes of myelodysplastic syndromes (MDS), as recently confirmed by the new 2016 WHO classification [1]. Nevertheless, morphologic diagnosis is not always self-evident. While increased blast cells are often in-line with advanced MDS subtypes, early forms with mild morphological changes can represent a diagnostic challenge. Especially in these cases, morphologic experience is crucial but should be embedded into further information on disease history, exclusion of other underlying diseases, as well as additional cytogenetic, molecular, and immunophenotypic data to confirm diagnosis of MDS.

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Author information

Authors and Affiliations

  1. Medizinische Klinik und Poliklinik 1, Universitätsklinikum Dresden, Dresden, Germany

    Katja Sockel, Frank Kroschinsky & Uta Oelschlaegel

  2. Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands

    Arjan A. van de Loosdrecht

Authors
  1. Katja Sockel
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  2. Frank Kroschinsky
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  3. Uta Oelschlaegel
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  4. Arjan A. van de Loosdrecht
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Corresponding author

Correspondence to Arjan A. van de Loosdrecht .

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Editors and Affiliations

  1. Medizinische Klinik und Poliklinik 1, Universitätsklinikum Dresden Medizinische Klinik und Poliklinik 1, Dresden, Sachsen, Germany

    Uwe Platzbecker

  2. Department of Hematology, Hospital Saint Louis, Paris, France

    Pierre Fenaux

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Sockel, K., Kroschinsky, F., Oelschlaegel, U., van de Loosdrecht, A.A. (2018). Morphology and Flow Cytometry. In: Platzbecker, U., Fenaux, P. (eds) Myelodysplastic Syndromes . Hematologic Malignancies. Springer, Cham. https://doi.org/10.1007/978-3-319-76879-3_1

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  • DOI: https://doi.org/10.1007/978-3-319-76879-3_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-76878-6

  • Online ISBN: 978-3-319-76879-3

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