Skip to main content
SpringerLink
Log in
Book cover

Osteochondral Tissue Engineering pp 391–413Cite as

Clinical Trials and Management of Osteochondral Lesions

  • Chapter
  • First Online:

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1058))

Abstract

Osteochondral lesions are frequent and important causes of pain and disability. These lesions are induced by traumatic injuries or by diseases that affect both the cartilage surface and the subchondral bone. Due to the limited cartilage ability to regenerate and self-repair, these lesions tend to gradually worsen and progress towards osteoarthritis. The clinical, social, and economic impact of the osteochondral lesions is impressive and although therapeutic alternatives are under discussion, a consensus is not yet been achieved. Over the previous decade, new strategies based on innovative tissue engineering approaches have been developed with promising results. However, in order those products reach the market and help the actual patient in an effective manner, there is still a lot of work to be done. The current state of the implications, clinical aspects, and available treatments for this pathology, as well as the ongoing preclinical and clinical trials are presented in this chapter.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Ondrésik M, Oliveira JM, Reis RL (2017) Knee articular cartilage. In: Oliveira JM, Reis RL (eds) Regenerative strategies for the treatment of knee joint disabilities. Springer International, Cham, pp 3–20. https://doi.org/10.1007/978-3-319-44785-8_1

    Chapter  Google Scholar 

  2. Pearle AD, Warren RF, Rodeo SA Basic science of articular cartilage and osteoarthritis. Clin Sports Med 24(1):1–12. https://doi.org/10.1016/j.csm.2004.08.007

    Article  PubMed  Google Scholar 

  3. Bolog NV, Andreisek G, Ulbrich EJ (2015) Articular cartilage and subchondral bone. In: MRI of the knee: a guide to evaluation and reporting. Springer International, Cham, pp 95–112. https://doi.org/10.1007/978-3-319-08165-6_6

    Chapter  Google Scholar 

  4. Flik KR, Verma N, Cole BJ, Bach BR (2007) Articular cartilage. In: Williams RJ (ed) Cartilage repair strategies. Humana Press, Totowa, NJ, pp 1–12. https://doi.org/10.1007/978-1-59745-343-1_1

    Chapter  Google Scholar 

  5. Goldring SR (2012) Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis. Ther Adv Musculoskelet Dis 4(4):249–258. https://doi.org/10.1177/1759720X12437353

    Article  PubMed  PubMed Central  Google Scholar 

  6. Imhof H, Sulzbacher I, Grampp S, Czerny C, Youssefzadeh S, Kainberger F (2000) Subchondral bone and cartilage disease: a rediscovered functional unit. Invest Radiol 35(10):581–588

    Article  CAS  PubMed  Google Scholar 

  7. Widuchowski W, Widuchowski J, Trzaska T (2007) Articular cartilage defects: study of 25,124 knee arthroscopies. Knee 14(3):177–182. https://doi.org/10.1016/j.knee.2007.02.001

    Article  CAS  PubMed  Google Scholar 

  8. Hjelle K, Solheim E, Strand T, Muri R, Brittberg M (2002) Articular cartilage defects in 1,000 knee arthroscopies. Arthroscopy 18(7):730–734

    Article  PubMed  Google Scholar 

  9. Aroen A, Loken S, Heir S, Alvik E, Ekeland A, Granlund OG, Engebretsen L (2004) Articular cartilage lesions in 993 consecutive knee arthroscopies. Am J Sports Med 32(1):211–215

    Article  PubMed  Google Scholar 

  10. Farr J, Cole B, Dhawan A, Kercher J, Sherman S (2011) Clinical cartilage restoration: evolution and overview. Clin Orthop Relat Res 469(10):2696–2705. https://doi.org/10.1007/s11999-010-1764-z

    Article  PubMed  PubMed Central  Google Scholar 

  11. Vaquero J, Forriol F (2012) Knee chondral injuries: clinical treatment strategies and experimental models. Injury 43(6):694–705. https://doi.org/10.1016/j.injury.2011.06.033

    Article  PubMed  Google Scholar 

  12. Foldager CB (2013) Advances in autologous chondrocyte implantation and related techniques for cartilage repair. Dan Med J 60(4):B4600

    PubMed  Google Scholar 

  13. Hunziker EB (1999) Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable? Osteoarthritis Cartilage 7(1):15–28. https://doi.org/10.1053/joca.1998.0159

    Article  CAS  PubMed  Google Scholar 

  14. Hunziker EB (2002) Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 10(6):432–463. https://doi.org/10.1053/joca.2002.0801

    Article  CAS  PubMed  Google Scholar 

  15. Johnson VL, Hunter DJ (2014) The epidemiology of osteoarthritis. Best Pract Res Clin Rheumatol 28(1):5–15. https://doi.org/10.1016/j.berh.2014.01.004

    Article  PubMed  Google Scholar 

  16. Jackson DW, Simon TM, Aberman HM (2001) Symptomatic articular cartilage degeneration: the impact in the new millennium. Clin Orthop Relat Res (391 Suppl):S14–25

    Article  Google Scholar 

  17. Nukavarapu SP, Dorcemus DL (2013) Osteochondral tissue engineering: current strategies and challenges. Biotechnol Adv 31(5):706–721. https://doi.org/10.1016/j.biotechadv.2012.11.004

    Article  CAS  PubMed  Google Scholar 

  18. Batty L, Dance S, Bajaj S, Cole BJ (2011) Autologous chondrocyte implantation: an overview of technique and outcomes. ANZ J Surg 81(1–2):18–25. https://doi.org/10.1111/j.1445-2197.2010.05495.x

    Article  PubMed  Google Scholar 

  19. Durur-Subasi I, Durur-Karakaya A, Yildirim OS (2015) Osteochondral lesions of major joints. Eur J Med 47(2):138–144. https://doi.org/10.5152/eurasianjmed.2015.50

    Article  Google Scholar 

  20. Lewandrowski KU, Muller J, Schollmeier G (1997) Concomitant meniscal and articular cartilage lesions in the femorotibial joint. Am J Sports Med 25(4):486–494

    Article  CAS  PubMed  Google Scholar 

  21. Vilela CA, Correia C, Oliveira JM, Sousa RA, Reis RL, Espregueira-Mendes J (2017) Clinical management of articular cartilage lesions. In: Oliveira JM, Reis RL (eds) Regenerative strategies for the treatment of knee joint disabilities. Springer International, Cham, pp 29–53. https://doi.org/10.1007/978-3-319-44785-8_3

    Chapter  Google Scholar 

  22. Resnick D, Vint V (1980) The “Tunnel” view in assessment of cartilage loss in osteoarthritis of the knee. Radiology 137(2):547–548. https://doi.org/10.1148/radiology.137.2.7433690

    Article  CAS  PubMed  Google Scholar 

  23. Rosenberg TD, Paulos LE, Parker RD, Coward DB, Scott SM (1988) The forty-five-degree posteroanterior flexion weight-bearing radiograph of the knee. J Bone Joint Surg Am 70(10):1479–1483

    Article  CAS  PubMed  Google Scholar 

  24. Casula V, Hirvasniemi J, Lehenkari P, Ojala R, Haapea M, Saarakkala S, Lammentausta E, Nieminen MT (2016) Association between quantitative MRI and ICRS arthroscopic grading of articular cartilage. Knee Surg Sports Traumatol Arthrosc 24(6):2046–2054. https://doi.org/10.1007/s00167-014-3286-9

    Article  PubMed  Google Scholar 

  25. Chan DD, Neu CP (2013) Probing articular cartilage damage and disease by quantitative magnetic resonance imaging. J R Soc Interface 10(78):20120608. https://doi.org/10.1098/rsif.2012.0608

    Article  PubMed  PubMed Central  Google Scholar 

  26. Vilela CA, Correia C, Oliveira JM, Sousa RA, Espregueira-Mendes J, Reis RL (2015) Cartilage repair using hydrogels: a critical review of in vivo experimental designs. ACS Biomater Sci Eng 1(9):726–739. https://doi.org/10.1021/acsbiomaterials.5b00245

    Article  CAS  PubMed  Google Scholar 

  27. Outerbridge RE (1961) The etiology of chondromalacia patellae. J Bone Joint Surg Br 43-B:752–757

    Article  CAS  PubMed  Google Scholar 

  28. Casscells SW (1990) Outerbridge’s ridges. Arthroscopy 6(4):253

    Article  CAS  PubMed  Google Scholar 

  29. Brittberg M, Winalski CS (2003) Evaluation of cartilage injuries and repair. J Bone Joint Surg Am 85-A(Suppl 2):58–69

    Article  Google Scholar 

  30. Chen CH, Liu YS, Chou PH, Hsieh CC, Wang CK (2013) MR grading system of osteochondritis dissecans lesions: comparison with arthroscopy. Eur J Radiol 82(3):518–525. https://doi.org/10.1016/j.ejrad.2012.09.026

    Article  PubMed  Google Scholar 

  31. Ellermann JM, Donald B, Rohr S, Takahashi T, Tompkins M, Nelson B, Crawford A, Rud C, Macalena J (2016) Magnetic resonance imaging of osteochondritis dissecans: validation study for the ICRS Classification System. Acad Radiol 23(6):724–729. https://doi.org/10.1016/j.acra.2016.01.015

    Article  PubMed  Google Scholar 

  32. Lazic S, Boughton O, Hing C, Bernard J (2014) Arthroscopic washout of the knee: a procedure in decline. Knee 21(2):631–634. https://doi.org/10.1016/j.knee.2014.02.014

    Article  PubMed  Google Scholar 

  33. Katz JN, Brownlee SA, Jones MH (2014) The role of arthroscopy in the management of knee osteoarthritis. Best Pract Res Clin Rheumatol 28(1):143–156. https://doi.org/10.1016/j.berh.2014.01.008

    Article  PubMed  PubMed Central  Google Scholar 

  34. Marcacci M, Filardo G, Kon E (2013) Treatment of cartilage lesions: what works and why? Injury 44(Suppl 1):S11–S15. https://doi.org/10.1016/S0020-1383(13)70004-4

    Article  PubMed  Google Scholar 

  35. Bentley G, Bhamra JS, Gikas PD, Skinner JA, Carrington R, Briggs TW (2013) Repair of osteochondral defects in joints—how to achieve success. Injury 44(Suppl 1):S3–10. https://doi.org/10.1016/S0020-1383(13)70003-2

    Article  PubMed  Google Scholar 

  36. Steadman JR, Briggs KK, Rodrigo JJ, Kocher MS, Gill TJ, Rodkey WG (2003) Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up. Arthroscopy 19(5):477–484. https://doi.org/10.1053/jars.2003.50112

    Article  PubMed  Google Scholar 

  37. Versier G, Dubrana F, French Arthroscopy S (2011) Treatment of knee cartilage defect in 2010. Orthop Traumatol Surg Res 97(8 Suppl):S140–S153. https://doi.org/10.1016/j.otsr.2011.09.007

    Article  CAS  PubMed  Google Scholar 

  38. Lee GW, Son JH, Kim JD, Jung GH (2013) Is platelet-rich plasma able to enhance the results of arthroscopic microfracture in early osteoarthritis and cartilage lesion over 40 years of age? Eur J Orthopaed Surg Traumatol 23(5):581–587. https://doi.org/10.1007/s00590-012-1038-4

    Article  Google Scholar 

  39. Tuan RS, Chen AF, Klatt BA (2013) Cartilage regeneration. J Am Acad Orthop Surg 21(5):303–311. https://doi.org/10.5435/JAAOS-21-05-303

    Article  PubMed  PubMed Central  Google Scholar 

  40. Chung JY, Lee DH, Kim TH, Kwack KS, Yoon KH, Min BH (2014) Cartilage extra-cellular matrix biomembrane for the enhancement of microfractured defects. Knee Surg Sports Traumatol Arthrosc 22(6):1249–1259. https://doi.org/10.1007/s00167-013-2716-4

    Article  PubMed  Google Scholar 

  41. Usuelli FG, de Girolamo L, Grassi M, D'Ambrosi R, Montrasio UA, Boga M All-arthroscopic autologous matrix-induced chondrogenesis for the treatment of osteochondral lesions of the talus. Arthrosc Tech 4(3):e255–e259. https://doi.org/10.1016/j.eats.2015.02.010

    Article  PubMed Central  PubMed  Google Scholar 

  42. Cascio BM, Sharma B The future of cartilage repair. Oper Tech Sports Med 16(4):221–224. https://doi.org/10.1053/j.otsm.2009.01.001

    Article  Google Scholar 

  43. Gomoll AH, Filardo G, de Girolamo L, Espregueira-Mendes J, Marcacci M, Rodkey WG, Steadman JR, Zaffagnini S, Kon E (2012) Surgical treatment for early osteoarthritis. Part I: cartilage repair procedures. Knee Surg Sports Traumatol Arthrosc 20(3):450–466. https://doi.org/10.1007/s00167-011-1780-x

    Article  CAS  PubMed  Google Scholar 

  44. Espregueira-Mendes J, Pereira H, Sevivas N, Varanda P, da Silva MV, Monteiro A, Oliveira JM, Reis RL (2012) Osteochondral transplantation using autografts from the upper tibio-fibular joint for the treatment of knee cartilage lesions. Knee Surg Sports Traumatol Arthrosc 20(6):1136–1142. https://doi.org/10.1007/s00167-012-1910-0

    Article  PubMed  Google Scholar 

  45. Robert H (2011) Chondral repair of the knee joint using mosaicplasty. Orthop Traumatol Surg Res 97(4):418–429. https://doi.org/10.1016/j.otsr.2011.04.001

    Article  CAS  PubMed  Google Scholar 

  46. Farr J, Cole BJ, Sherman S, Karas V (2012) Particulated articular cartilage: CAIS and DeNovo NT. J Knee Surg 25(1):23–29

    Article  PubMed  Google Scholar 

  47. Stein S, Strauss E, Bosco J 3rd (2013) Advances in the surgical management of articular cartilage defects: autologous chondrocyte implantation techniques in the pipeline. Cartilage 4(1):12–19. https://doi.org/10.1177/1947603512463226

    Article  PubMed  PubMed Central  Google Scholar 

  48. Gomoll AH, Filardo G, Almqvist FK, Bugbee WD, Jelic M, Monllau JC, Puddu G, Rodkey WG, Verdonk P, Verdonk R, Zaffagnini S, Marcacci M (2012) Surgical treatment for early osteoarthritis. Part II: allografts and concurrent procedures. Knee Surg Sports Traumatol Arthrosc 20(3):468–486. https://doi.org/10.1007/s00167-011-1714-7

    Article  CAS  PubMed  Google Scholar 

  49. Haene R, Qamirani E, Story RA, Pinsker E, Daniels TR (2012) Intermediate outcomes of fresh talar osteochondral allografts for treatment of large osteochondral lesions of the talus. J Bone Joint Surg Am 94(12):1105–1110. https://doi.org/10.2106/JBJS.J.02010

    Article  PubMed  Google Scholar 

  50. Giorgini A, Donati D, Cevolani L, Frisoni T, Zambianchi F, Catani F (2013) Fresh osteochondral allograft is a suitable alternative for wide cartilage defect in the knee. Injury 44(Suppl 1):S16–S20. https://doi.org/10.1016/S0020-1383(13)70005-6

    Article  PubMed  Google Scholar 

  51. Pina S, Ribeiro V, Oliveira JM, Reis RL (2017) Pre-clinical and clinical management of osteochondral lesions. In: Oliveira JM, Reis RL (eds) Regenerative strategies for the treatment of knee joint disabilities. Springer International, Cham, pp 147–161. https://doi.org/10.1007/978-3-319-44785-8_8

    Chapter  Google Scholar 

  52. Barrett I, King AH, Riester S, van Wijnen A, Levy BA, Stuart MJ, Krych AJ (2016) Internal fixation of unstable osteochondritis dissecans in the skeletally mature knee with metal screws. Cartilage 7(2):157–162. https://doi.org/10.1177/1947603515622662

    Article  PubMed  Google Scholar 

  53. Grimm NL, Ewing CK, Ganley TJ (2014) The knee internal fixation techniques for osteochondritis dissecans. Clin Sports Med 33(2):313–319. https://doi.org/10.1016/j.csm.2013.12.001

    Article  PubMed  Google Scholar 

  54. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331(14):889–895. https://doi.org/10.1056/NEJM199410063311401

    Article  CAS  PubMed  Google Scholar 

  55. Dhollander AA, Verdonk PC, Lambrecht S, Verdonk R, Elewaut D, Verbruggen G, Almqvist KF (2012) Short-term outcome of the second generation characterized chondrocyte implantation for the treatment of cartilage lesions in the knee. Knee Surg Sports Traumatol Arthrosc 20(6):1118–1127. https://doi.org/10.1007/s00167-011-1759-7

    Article  CAS  PubMed  Google Scholar 

  56. Zaslav K, Cole B, Brewster R, DeBerardino T, Farr J, Fowler P, Nissen C, Investigators SSP (2009) A prospective study of autologous chondrocyte implantation in patients with failed prior treatment for articular cartilage defect of the knee: results of the Study of the Treatment of Articular Repair (STAR) clinical trial. Am J Sports Med 37(1):42–55. https://doi.org/10.1177/0363546508322897

    Article  PubMed  Google Scholar 

  57. D’Ambrosi R, Maccario C, Ursino C, Serra N, Usuelli FG (2017) Combining microfractures, autologous bone graft, and autologous matrix-induced chondrogenesis for the treatment of juvenile osteochondral talar lesions. Foot Ankle Int 38(5):485–495. https://doi.org/10.1177/1071100716687367

    Article  PubMed  Google Scholar 

  58. Jacobi M, Villa V, Magnussen RA, Neyret P (2011) MACI—a new era? Sports Med Arthrosc Rehabil Ther Technol 3(1):10. https://doi.org/10.1186/1758-2555-3-10

    Article  PubMed  PubMed Central  Google Scholar 

  59. Kreuz PC, Müller S, Ossendorf C, Kaps C, Erggelet C (2009) Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results. Arthritis Res Ther 11(2):R33. https://doi.org/10.1186/ar2638

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Selmi TA, Verdonk P, Chambat P, Dubrana F, Potel JF, Barnouin L, Neyret P (2008) Autologous chondrocyte implantation in a novel alginate-agarose hydrogel: outcome at two years. J Bone Joint Surg Br 90(5):597–604. https://doi.org/10.1302/0301-620X.90B5.20360

    Article  CAS  PubMed  Google Scholar 

  61. Clavé A, Potel J-F, Servien E, Neyret P, Dubrana F, Stindel E (2016) Third-generation autologous chondrocyte implantation versus mosaicplasty for knee cartilage injury: 2-year randomized trial. J Orthop Res 4(4):658–665. https://doi.org/10.1002/jor.23152

    Article  CAS  Google Scholar 

  62. Brix MO, Stelzeneder D, Chiari C, Koller U, Nehrer S, Dorotka R, Windhager R, Domayer SE (2014) Treatment of full-thickness chondral defects with Hyalograft C in the knee. Am J Sports Med 42(6):1426–1432. https://doi.org/10.1177/0363546514526695

    Article  PubMed  Google Scholar 

  63. Zak L, Albrecht C, Wondrasch B, Widhalm H, Vekszler G, Trattnig S, Marlovits S, Aldrian S (2014) Results 2 years after matrix-associated autologous chondrocyte transplantation using the Novocart 3D scaffold. Am J Sports Med 42(7):1618–1627. https://doi.org/10.1177/0363546514532337

    Article  PubMed  Google Scholar 

  64. Crawford DC, DeBerardino TM, Williams RJ 3rd (2012) NeoCart, an autologous cartilage tissue implant, compared with microfracture for treatment of distal femoral cartilage lesions: an FDA phase-II prospective, randomized clinical trial after two years. J Bone Joint Surg Am 94(11):979–989. https://doi.org/10.2106/JBJS.K.00533

    Article  PubMed  Google Scholar 

  65. Yayon A, Neria E, Blumenstein S, Stern B, Barkai H, Zak R, Yaniv Y (2006) BIOCART™II a novel implant for 3D reconstruction of articular cartilage. J Bone Jt Surg Br 88-B(SUPP II):344

    Google Scholar 

  66. Zeifang F, Oberle D, Nierhoff C, Richter W, Moradi B, Schmitt H (2010) Autologous chondrocyte implantation using the original periosteum-cover technique versus matrix-associated autologous chondrocyte implantation: a randomized clinical trial. Am J Sports Med 38(5):924–933. https://doi.org/10.1177/0363546509351499

    Article  PubMed  Google Scholar 

  67. Dewan AK, Gibson MA, Elisseeff JH, Trice ME (2014) Evolution of autologous chondrocyte repair and comparison to other cartilage repair techniques. Biomed Res Int 2014:272481. https://doi.org/10.1155/2014/272481

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. McCormick F, Cole BJ, Nwachukwu B, Harris JD, Adkisson HDIV, Farr J Treatment of focal cartilage defects with a juvenile allogeneic 3-dimensional articular cartilage graft. Oper Tech Sports Med 21(2):95–99. https://doi.org/10.1053/j.otsm.2013.03.007

    Article  Google Scholar 

  69. Rodriguez-Merchan EC (2013) Regeneration of articular cartilage of the knee. Rheumatol Int 33(4):837–845. https://doi.org/10.1007/s00296-012-2601-3

    Article  CAS  PubMed  Google Scholar 

  70. Schüttler KF, Schenker H, Theisen C, Schofer MD, Getgood A, Roessler PP, Struewer J, Rominger MB, Efe T (2014) Use of cell-free collagen type I matrix implants for the treatment of small cartilage defects in the knee: clinical and magnetic resonance imaging evaluation. Knee Surg Sports Traumatol Arthrosc 22(6):1270–1276. https://doi.org/10.1007/s00167-013-2747-x

    Article  PubMed  Google Scholar 

  71. Perera JR, Gikas PD, Bentley G (2012) The present state of treatments for articular cartilage defects in the knee. Ann R Coll Surg Engl 94(6):381–387. https://doi.org/10.1308/003588412X13171221592573

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Negrin LL, Vecsei V (2013) Do meta-analyses reveal time-dependent differences between the clinical outcomes achieved by microfracture and autologous chondrocyte implantation in the treatment of cartilage defects of the knee? J Orthop Sci 18(6):940–948. https://doi.org/10.1007/s00776-013-0449-3

    Article  CAS  PubMed  Google Scholar 

  73. Petri M, Broese M, Simon A, Liodakis E, Ettinger M, Guenther D, Zeichen J, Krettek C, Jagodzinski M, Haasper C (2013) CaReS (MACT) versus microfracture in treating symptomatic patellofemoral cartilage defects: a retrospective matched-pair analysis. J Orthop Sci 18(1):38–44. https://doi.org/10.1007/s00776-012-0305-x

    Article  PubMed  Google Scholar 

  74. Gelber PE, Batista J, Millan-Billi A, Patthauer L, Vera S, Gomez-Masdeu M, Monllau JC (2014) Magnetic resonance evaluation of TruFit(R) plugs for the treatment of osteochondral lesions of the knee shows the poor characteristics of the repair tissue. Knee 21(4):827–832. https://doi.org/10.1016/j.knee.2014.04.013

    Article  PubMed  Google Scholar 

  75. Hindle P, Hendry JL, Keating JF, Biant LC (2014) Autologous osteochondral mosaicplasty or TruFit plugs for cartilage repair. Knee Surg Sports Traumatol Arthrosc 22(6):1235–1240. https://doi.org/10.1007/s00167-013-2493-0

    Article  PubMed  Google Scholar 

  76. Delcogliano M, de Caro F, Scaravella E, Ziveri G, De Biase CF, Marotta D, Marenghi P, Delcogliano A (2014) Use of innovative biomimetic scaffold in the treatment for large osteochondral lesions of the knee. Knee Surg Sports Traumatol Arthrosc 22(6):1260–1269. https://doi.org/10.1007/s00167-013-2717-3

    Article  PubMed  Google Scholar 

  77. Stanish WD, McCormack R, Forriol F, Mohtadi N, Pelet S, Desnoyers J, Restrepo A, Shive MS (2013) Novel scaffold-based BST-CarGel treatment results in superior cartilage repair compared with microfracture in a randomized controlled trial. J Bone Joint Surg Am 95(18):1640–1650. https://doi.org/10.2106/JBJS.L.01345

    Article  PubMed  Google Scholar 

  78. Shive MS, Hoemann CD, Restrepo A, Hurtig MB, Duval N, Ranger P, Stanish W, Buschmann MD (2006) BST-CarGel: in situ chondroinduction for cartilage repair. Oper Tech Orthopaed 16(4):271–278. https://doi.org/10.1053/j.oto.2006.08.001

    Article  Google Scholar 

  79. Schüettler KF, Struewer J, Rominger MB, Rexin P, Efe T (2013) Repair of a chondral defect using a cell free scaffold in a young patient—a case report of successful scaffold transformation and colonisation. BMC Surg 13(1):11. https://doi.org/10.1186/1471-2482-13-11

    Article  PubMed  PubMed Central  Google Scholar 

  80. Roessler PP, Pfister B, Gesslein M, Figiel J, Heyse TJ, Colcuc C, Lorbach O, Efe T, Schüttler KF (2015) Short-term follow up after implantation of a cell-free collagen type I matrix for the treatment of large cartilage defects of the knee. Int Orthop 39(12):2473–2479. https://doi.org/10.1007/s00264-015-2695-9

    Article  PubMed  Google Scholar 

  81. Panseri S, Russo A, Cunha C, Bondi A, Di Martino A, Patella S, Kon E (2012) Osteochondral tissue engineering approaches for articular cartilage and subchondral bone regeneration. Knee Surg Sports Traumatol Arthrosc 20(6):1182–1191. https://doi.org/10.1007/s00167-011-1655-1

    Article  PubMed  Google Scholar 

  82. Mall NA, Harris JD, Cole BJ (2015) Clinical evaluation and preoperative planning of articular cartilage lesions of the knee. J Am Acad Orthop Surg 23(10):633–640. https://doi.org/10.5435/JAAOS-D-14-00241

    Article  PubMed  Google Scholar 

  83. Agency E-EM (2009) Reflection paper on in-vitro cultured chondrocyte containing products for cartilage repair of the knee—Doc. Ref. EMEA/CAT/CPWP/288934/2009. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/10/WC500004223.pdf. Acessed Mar 2017

  84. Administration F-FD (2011) Guidance for Industry—preparation of IDEs and INDs dor products intended to repair or replace knee cartilage. http://www.fda.gov/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/default.htm. Accessed Mar 2017

  85. Administration F-FD (2017) Learn about clinical studies. https://clinicaltrials.gov/ct2/about-studies/learn#WhatIs. Accessed Mar 2017

  86. Administratioon F-FD (2017) Clinical trias. https://clinicaltrials.gov/ct2/home. Accessed Mar 2017

Download references

Acknowledgments

A. da Silva Morais acknowledges ERC-2012-ADG 20120216–321266 (ComplexiTE) for his Postdoc scholarship. Thanks to the project FROnTHERA (NORTE-01-0145-FEDER-000023), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). The financial support from the Portuguese Foundation for Science and Technology for the M-ERA-NET/0001/2014 “HierarchiTech” project and for the funds provided under the program Investigador FCT 2012, 2014, and 2015 (IF/00423/2012, IF/01214/2014, and IF/01285/2015) is also greatly acknowledged.

Author information

Authors and Affiliations

  1. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal

    Carlos A. Vilela, Alain da Silva Morais, Vitor M. Correlo & Rui L. Reis

  2. Orthopedic Department, Centro Hospitalar do Alto Ave, Guimarães, Portugal

    Carlos A. Vilela, Alain da Silva Morais, Vitor M. Correlo, Rui L. Reis & João Espregueira-Mendes

  3. Dom Henrique Research Centre, Porto, Portugal

    Carlos A. Vilela, Carlos A. Vilela, Vitor M. Correlo & Rui L. Reis

  4. 3B’s Research Group, European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Guimarães, Portugal

    Sandra Pina, J. Miguel Oliveira & João Espregueira-Mendes

  5. ICVS/3B’s–PT Government Associate Laboratory, Braga/Guimarães, Portugal

    Carlos A. Vilela, Sandra Pina, J. Miguel Oliveira & João Espregueira-Mendes

  6. The Discoveries Centre for Regenerative and Precision Medicine, University of Minho, Barco/Guimarães, Portugal

    J. Miguel Oliveira & João Espregueira-Mendes

  7. Clínica do Dragão—Espregueira-Mendes Sports Centre, FIFA Medical Centre of Excellence, Porto, Portugal

    João Espregueira-Mendes

Authors
  1. Carlos A. Vilela
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alain da Silva Morais
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sandra Pina
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Miguel Oliveira
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Vitor M. Correlo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Rui L. Reis
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. João Espregueira-Mendes
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    J. Miguel Oliveira

  2. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    Sandra Pina

  3. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    Rui L. Reis

  4. Polymeric Nanomaterials and Biomaterials Department, Institute of Polymer Science and Technology, Spanish Council for Scientific Research (CSIC), Madrid, Spain

    Julio San Roman

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Vilela, C.A. et al. (2018). Clinical Trials and Management of Osteochondral Lesions. In: Oliveira, J., Pina, S., Reis, R., San Roman, J. (eds) Osteochondral Tissue Engineering. Advances in Experimental Medicine and Biology, vol 1058. Springer, Cham. https://doi.org/10.1007/978-3-319-76711-6_18

Download citation

Publish with us

Policies and ethics

Search

Navigation