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Drug Adherence in Hypertension and Cardiovascular Protection pp 185–197Cite as

Drug Adherence in Resistant Hypertension

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Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

Abstract

Non-adherence to antihypertensive treatment is recognized as a major factor affecting their effectiveness in hypertensive patients contributing to treatment resistance. Indeed, non-adherence is highly prevalent in patients with resistant hypertension. However, it is often overlooked because the methods to assess non-adherence are partly unreliable and thus limit their use in clinical practice. Non-adherence to treatment can affect daily patient management, resulting in inappropriate, costly, and potentially harmful treatment and loss of benefits expected from antihypertensive drugs. Indeed, non-adherence is associated with poor cardiovascular, cerebrovascular, and renal outcomes. Thus, improved screening tools, including therapeutic drug monitoring, are needed to detect non-adherence in patients with resistant hypertension, thus enabling appropriate interventions to improve drug adherence and avoid unnecessary treatment intensification. Given the expanding population with uncontrolled and resistant hypertension and emerging cost–benefits of adherence, addressing non-adherence to prescribed antihypertensive therapy is a top priority.

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Authors and Affiliations

  1. Department of Pharmacology and Hypertension Unit, Hopital Europeen Georges Pompidou, Assistance-Publique Hopitaux de Paris, Paris, France

    Idir Hamdidouche, Vincent Jullien, Stéphane Laurent & Michel Azizi

  2. Paris-Descartes University, Paris, France

    Idir Hamdidouche, Vincent Jullien, Stéphane Laurent & Michel Azizi

  3. INSERM UMRS970, Paris, France

    Idir Hamdidouche & Stéphane Laurent

  4. INSERM CIC1418, Paris, France

    Michel Azizi

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  1. Idir Hamdidouche
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  2. Vincent Jullien
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  3. Stéphane Laurent
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  4. Michel Azizi
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Correspondence to Michel Azizi .

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Editors and Affiliations

  1. Service of Nephrology and Hypertension, CHUV, University of Lausanne, Lausanne, Vaud, Switzerland

    Michel Burnier

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Hamdidouche, I., Jullien, V., Laurent, S., Azizi, M. (2018). Drug Adherence in Resistant Hypertension. In: Burnier, M. (eds) Drug Adherence in Hypertension and Cardiovascular Protection. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-319-76593-8_14

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