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Inflammation

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Nuclear Medicine Companion

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Abstract

In-111 leukocyte (white blood cell—WBC) imaging is mainly used to diagnose various acute infections, particularly in musculoskeletal system (osteomyelitis in areas other than the spine). It is also used to diagnose infected vascular grafts, infected central venous catheters or other devices, fever of unknown origin (FUO), postoperative abscesses, inflammatory bowel disease, lung infections, endocarditis, and neurological infections.

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References

  1. Society of Nuclear Medicine Procedure Guideline for 111In-Leukocyte Scintigraphy for Suspected Infection/Inflammation Version 3.0, approved June 2, 2004

    Google Scholar 

  2. Palestro CJ, Love C (2007) Radionuclide imaging of musculoskeletal infection: conventional agents. Semin Musculoskelet Radiol 11:335–352

    Article  PubMed  Google Scholar 

  3. Bar-Shalom R, Yefremov N, Guralnik L, Keidar Z, Engel A et al (2006) SPECT/CT using 67Ga and 111In-labeled leukocyte scintigraphy for diagnosis of infection. J Nucl Med 47:587–594

    PubMed  Google Scholar 

  4. Nasseri F, Bhargava P (2012) Prosthesis-related abscess on In-111 leukocyte SPECT/CT imaging. Nucl Med Mol Imaging 46:76–77

    Article  PubMed  Google Scholar 

  5. Heiba SI, Kolker D, Mocherla B, Kapoor K, Jiang M et al (2010) The optimized evaluation of diabetic foot infection by dual isotope SPECT/CT imaging protocol. J Foot Ankle Surg 49:529–536

    Article  PubMed  Google Scholar 

  6. Nasu R, Akagi K, Murata T, Uokawa K, Isoda H et al (1998) In-111 labeled leukocyte scintigraphy in patients with suspected inflammation after failed antibiotic therapy. Radiat Med 16:347–351

    PubMed  CAS  Google Scholar 

  7. Society of Nuclear Medicine Procedure Guideline for Tc-99m Exametazime (HMPAO) Labeled Leukocyte Scintigraphy for Suspected Infection/Inflammation version 2.0, approved February 7, 1999

    Google Scholar 

  8. de Vries EF, Roca M, Jamar F, Israel O, Signore A (2010) Guidelines for the labelling of leucocytes with (99m)Tc-HMPAO. Inflammation/Infection Task group of the European Association of Nuclear Medicine. Eur J Nucl Med Mol Imaging 37:842–848

    Article  PubMed  PubMed Central  Google Scholar 

  9. Palestro CJ, Love C, Tronco GG, Tomas MB, Rini JN (2006) Combined labeled leukocyte and technetium 99m sulfur colloid bone marrow imaging for diagnosing musculoskeletal infection. Radiographics 26:859–870

    Article  PubMed  Google Scholar 

  10. Filippi L, Schillaci O (2006) Usefulness of hybrid SPECT/CT in 99mTc-HMPAO-labeled leukocyte scintigraphy for bone and joint infections. J Nucl Med 47:1908–1913

    PubMed  CAS  Google Scholar 

  11. Djekidel M, Brown RK, Piert M (2011) Benefits of hybrid SPECT/CT for (111)In-oxine- and Tc-99m-hexamethylpropylene amine oxime-labeled leukocyte imaging. Clin Nucl Med 36:50–56

    Article  Google Scholar 

  12. Hughes DK (2003) Nuclear medicine and infection detection: the relative effectiveness of imaging with 111In-oxine-, 99mTc-HMPAO-, and 99mTc-stannous fluoride colloid-labeled leukocytes and with 67Ga-citrate. J Nucl Med Technol 31:196–201

    PubMed  CAS  Google Scholar 

  13. Glaudemans AW, Galli F, Pacilio M, Signore A (2013) Leukocyte and bacteria imaging in prosthetic joint infection. Eur Cell Mater 25:61–77

    Article  PubMed  Google Scholar 

  14. Hoffer P (1980) Gallium: mechanisms. J Nucl Med 21:282–285

    PubMed  CAS  Google Scholar 

  15. Sephton R, Martin JJ (1980) Modification of distribution of gallium-67 in man by administration of iron. Br J Radiol 53:572–575

    Article  CAS  PubMed  Google Scholar 

  16. Hattner RS, White DL (1990) Gallium-67/stable gadolinium antagonism: MRI contrast agent markedly alters the normal biodistribution of Gallum-67. J Nucl Med 31:1844–1846

    PubMed  CAS  Google Scholar 

  17. Seabold JE, Palestro CJ, Brown ML, Datz FL, Forstrom LA et al (1997) Procedure guideline for gallium scintigraphy in inflammation. Society of Nuclear Medicine. J Nucl Med 38:994–997

    PubMed  CAS  Google Scholar 

  18. Palestro CJ (1994) The current role of gallium imaging in infection. Semin Nuc Med 14:128–141

    Article  Google Scholar 

  19. Quigley AM, Gnanasegaran G, Buscombe JR, Hilson AJ (2008) Technetium-99m-labelled sulesomab (LeukoScan) in the evaluation of soft tissue infections. Med Princ Pract 17:447–452

    Article  PubMed  Google Scholar 

  20. Rubello D, Rampin L, Banti E, Grassetto G, Massaro A et al (2008) Antigranulocyte scintigraphy in infected hip prosthesis: the diagnostic importance delayed 20-24-h imaging and semiquantitative analysis. Nucl Med Commun 29:994–998

    Article  PubMed  Google Scholar 

  21. Gratz S, Schipper ML, Dorner J, Höffken H, Becker W et al (2003) LeukoScan for imaging infection in different clinical settings: a retrospective evaluation and extended review of the literature. Clin Nucl Med 28:267–276

    PubMed  CAS  Google Scholar 

  22. Devillers A, Garin E, Polard JL, Poirier JY, Arvieux C et al (2000) Comparison of Tc-99m-labelled antileukocyte fragment Fab’ and Tc-99m-HMPAO leukocyte scintigraphy in the diagnosis of bone and joint infections: a prospective study. Nucl Med Commun 21:747–753

    Article  CAS  PubMed  Google Scholar 

  23. Kerry JE, Marshall C, Griffiths PA, James MW, Scott BB (2005) Comparison between Tc-HMPAO labelled white cells and Tc LeukoScan in the investigation of inflammatory bowel disease. Nucl Med Commun 26:245–251

    Article  PubMed  Google Scholar 

  24. Jamar F, Buscombe J, Chiti A, Christian PE, Delbeke D et al (2013) EANM/SNMMI guideline for 18F-FDG use in inflammation and infection. J Nucl Med 54:647–658

    Article  PubMed  Google Scholar 

  25. Blockmans D, de Ceuninck L, Vanderschueren S, Knockaert D, Mortelmans L et al (2006) Repetitive 18F-fluorodeoxyglucose positron emission tomography in giant cell arteritis: a prospective study of 35 patients. Arthritis Rheum 55:131–137

    Article  PubMed  Google Scholar 

  26. Rabkin Z, Israel O, Keidar Z (2010) Do hyperglycemia and diabetes affect the incidence of false-negative 18F-FDG PET/CT studies in patients evaluated for infection or inflammation and cancer? A comparative analysis. J Nucl Med 51:1015–1020

    Article  PubMed  Google Scholar 

  27. Annovazzi A, Bagni B, Burroni L, D’Alessandria C, Signore A (2005) Nuclear medicine imaging of inflammatory/infective disorders of the abdomen. Nucl Med Commun 26:657–664

    Article  PubMed  Google Scholar 

  28. Ingui CJ, Shah NP, Oates ME (2007) Infection scintigraphy: added value of single-photon emission computed tomography/computed tomography fusion compared with traditional analysis. J Comput Assist Tomogr 31:375–380

    Article  PubMed  Google Scholar 

  29. Caobelli F, Panarotto MB, Andreoli F, Ravelli A, De Agostini A et al (2011) Is 99mTc-HMPAO granulocyte scan an alternative to endoscopy in pediatric chronic inflammatory bowel disease (IBD)? Eur J Pediatr 170:51–57

    Article  PubMed  Google Scholar 

  30. Meller J, Sahlmann CO, Scheel AK (2007) 18F-FDG PET and PET/CT in fever of unknown origin. J Nucl Med 48:35–45

    PubMed  CAS  Google Scholar 

  31. Stumpe KD, Dazzi H, Schaffner A, von Schulthess GK (2000) Infection imaging using whole-body FDG PET. Eur J Nucl Med 27:822–832

    Article  CAS  PubMed  Google Scholar 

  32. Bleeker-Rovers CP, deKleijn EM, Corstens FH, van der Meer JW, Oyen WJ (2004) Clinical value of FDG PET in patients with fever of unknown origin and patients suspected of focal infection or inflammation. Eur J Nucl Med Mol Imaging 31:29–37

    Article  PubMed  Google Scholar 

  33. Schroeder T, Melo MF, Venegas JG (2011) Analysis of 2-[Fluorine-18]-Fluoro-2-deoxy-D-glucose uptake kinetics in PET studies of pulmonary inflammation. Acad Radiol 18:418–423

    Article  PubMed  PubMed Central  Google Scholar 

  34. Gupta SM, Sziklas JJ, Spencer RP, Rosenberg R (1980) Significance of diffuse pulmonary uptake in radio gallium scans: concise communication. J Nucl Med 21:328–332

    PubMed  CAS  Google Scholar 

  35. Charron M, Ackerman ES, Kolodny GM, Rosenthall L (1988) Focal lung uptake of gallium-67 in patients with acquired immunodeficiency syndrome secondary to pneumocystis carinii pneumonia. Eur J Nucl Med 14:424–426

    PubMed  CAS  Google Scholar 

  36. Kono M, Yamashita H, Kubota K, Kano T, Mimori A (2015) FDG PET imaging in pneumocystis pneumonia. Clin Nucl Med 40:679–681

    Article  PubMed  Google Scholar 

  37. Huang CJ, You DL, Lee PI, Hsu LH, Liu CC et al (2009) Characteristics of integrated 18F-FDG PET/CT in pulmonary cryptococcosis. Acta Radiol 50:374–378

    Article  PubMed  Google Scholar 

  38. Bakheet SM, Powe J, Ezzat A, Rostom A (1998) F-18-FDG uptake in tuberculosis. Clin Nucl Med 23:739–742

    Article  CAS  PubMed  Google Scholar 

  39. Güngör T, Engel-Bicik I, Eich G, Willi UV, Nadal D et al (2001) Diagnostic and therapeutic impact of whole body positron emission tomography using fluorine-18-fluoro-2-deoxy-D-glucose in children with chronic granulomatous disease. Arch Dis Child 85:341–345

    Article  PubMed  PubMed Central  Google Scholar 

  40. Hardoff R, Gips S, Uri N, Front A, Tamir A (1994) Semiquantitative skull planar and SPECT bone scintigraphy in diabetic patients: differentiation of necrotizing (malignant) external otitis from severe external otitis. J Nucl Med 35:411–415

    PubMed  CAS  Google Scholar 

  41. Stokkel MP, Boot CN, van Eck-Smit BL (1996) SPECT gallium scintigraphy in malignant external otitis: initial staging and follow-up. Case reports. Laryngoscope 106:338–340

    Article  CAS  PubMed  Google Scholar 

  42. Sheng JF, Sheng ZK, Shen XM, Bi S, Li JJ et al (2011) Diagnostic value of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in patients with fever of unknown origin. Eur J Intern Med 22:112–116

    Article  PubMed  Google Scholar 

  43. Keidar Z, Gurman-Balbir A, Gaitini D, Israel O (2008) Fever of unknown origin: the role of 18F-FDG PET/CT. J Nucl Med 49:1980–1985

    Article  PubMed  Google Scholar 

  44. Crouzet J, Boudousq V, Lechiche C, Pouget JP, Kotzki PO et al (2012) Place of (18)F-FDG-PET with computed tomography in the diagnostic algorithm of patients with fever of unknown origin. Eur J Clin Microbiol Infect Dis 31:1727–1733

    Article  CAS  PubMed  Google Scholar 

  45. Balink H, Collins J, Bruyn GA, Gemmel F (2009) F-18 FDG PET/CT in the diagnosis of fever of unknown origin. Clin Nucl Med 34:862–868

    Article  PubMed  Google Scholar 

  46. Lee VW, Fuller JD, O'Brien MJ, Parker DR, Cooley TP et al (1991) Pulmonary Kaposi sarcoma in patients with AIDS: scintigraphic diagnosis with sequential thallium and gallium scanning. Radiology 180:409–412

    Article  CAS  PubMed  Google Scholar 

  47. Palestro CJ, Goldsmith SJ (1995) The role of gallium and labeled leukocyte scintigraphy in the AIDS patient. Q J Nucl Med 39:221–230

    PubMed  CAS  Google Scholar 

  48. Köhn H, Armbruster C, König B, Vetter N, Mostbeck A (1993) Contribution of nuclear medicine to management of pulmonary complications in patients with acquired immune deficiency. Acta Med Austriaca 20:36–41

    PubMed  Google Scholar 

  49. Ruiz A, Ganz WI, Post MJ, Camp A, Landy H et al (1994) Use of thallium-201 brain SPECT to differentiate cerebral lymphoma from toxoplasma encephalitis in AIDS patients. AJNR Am J Neuroradiol l15:1885–1894

    Google Scholar 

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Authors and Affiliations

  1. Department of Nuclear Medicine, Kuwait University, Safat, Kuwait

    Abdelhamid H. Elgazzar & Ismet Sarikaya

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  1. Abdelhamid H. Elgazzar
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  2. Ismet Sarikaya
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Elgazzar, A.H., Sarikaya, I. (2018). Inflammation. In: Nuclear Medicine Companion. Springer, Cham. https://doi.org/10.1007/978-3-319-76156-5_9

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  • DOI: https://doi.org/10.1007/978-3-319-76156-5_9

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