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The Role of Melanin-Concentrating Hormone in the Regulation of the Sleep/Wake Cycle: Sleep Promoter or Arousal Modulator?

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Melanin-Concentrating Hormone and Sleep

Abstract

The neuronal system that resides in the perifornical/lateral hypothalamus (Pf/LH) and synthesizes the neuropeptide melanin-concentrating hormone (MCH) participates in critical brain functions across species from fish to human. The MCH system was originally reported to regulate neural activity responsible for the change of skin color in lower vertebrates (such as fish), homeostatic functions (e.g., feeding and energy balance), and complex behaviors (e.g., reward seeking/addiction, depression/anxiety) in higher animals. The most recent evidence indicates that MCH participates in the regulation of sleep in animals as well. In this chapter, we summarize the evidence supporting the role of MCH in the regulation of sleep homeostasis in animals and discuss its physiological implications in the context of MCH as a central node of the overall brain circuitry controlling physiological functions and complex behaviors in animals.

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Acknowledgments

The author’s work has been supported by NIH/NIDA grant DA040782-01A1. The author would like to thank Ms. Marya Shanabrough for assistance in preparing the manuscript.

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Authors and Affiliations

  1. Department of Comparative Medicine, Program on Integrative Cell Signaling and Neurobiology of Metabolism (ICSNM), Yale University School of Medicine, New Haven, CT, USA

    Xiao-Bing Gao

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Correspondence to Xiao-Bing Gao .

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  1. Somnogen Canada Inc. , Toronto, Ontario, Canada

    S. R. Pandi-Perumal

  2. Department of Physiology, School of Medicine, University of the Republic, Montevideo, Uruguay

    Pablo Torterolo

  3. Department of Pharmacology and Therapeutics, School of Medicine Clinics Hospital, University of the Republic, Montevideo, Uruguay

    Jaime M. Monti

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Gao, XB. (2018). The Role of Melanin-Concentrating Hormone in the Regulation of the Sleep/Wake Cycle: Sleep Promoter or Arousal Modulator?. In: Pandi-Perumal, S., Torterolo, P., Monti, J. (eds) Melanin-Concentrating Hormone and Sleep . Springer, Cham. https://doi.org/10.1007/978-3-319-75765-0_3

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