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Melanin-Concentrating Hormone in Medical Conditions

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Melanin-Concentrating Hormone and Sleep

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Abstract

In the last decade, there was an impressive advance in the knowledge of the anatomy and physiology of the melanin-concentrating hormone (MCH) neuronal system. However, its role in pathology is still not clear. MCH is a peptidergic neuromodulator synthesized by neurons whose somas are mainly located in the posterolateral hypothalamus and incerto-hypothalamic area. The MCHergic neurons project throughout the central nervous system innervating areas involved in several physiological functions. MCH exerts its biological effects acting through two metabotropic receptors. There are substantive experimental data suggesting that the MCHergic system is involved in the control of energy homeostasis, mood, and sleep. In the present study, we summarize data related to the role of MCH in these functions, as well as preclinical and clinical evidences showing that dysfunction of the MCHergic system might be involved in several medical disorders including obesity, central hypersomnia, mood disorders, and ciliopathies.

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Acknowledgments

This work was partially supported by the “Programa de desarrollo de ciencias básicas,” PEDECIBA, Uruguay.

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Authors and Affiliations

  1. Department of Physiology, School of Medicine, University of the Republic, Montevideo, Uruguay

    Alicia Costa, Luciana Benedetto, Patricia Lagos & Pablo Torterolo

  2. Department of Pharmacology and Therapeutics, School of Medicine Clinics Hospital, University of the Republic, Montevideo, Uruguay

    Jaime M. Monti

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  1. Alicia Costa
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  2. Luciana Benedetto
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  1. Somnogen Canada Inc. , Toronto, Ontario, Canada

    S. R. Pandi-Perumal

  2. Department of Physiology, School of Medicine, University of the Republic, Montevideo, Uruguay

    Pablo Torterolo

  3. Department of Pharmacology and Therapeutics, School of Medicine Clinics Hospital, University of the Republic, Montevideo, Uruguay

    Jaime M. Monti

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Costa, A., Benedetto, L., Lagos, P., Monti, J.M., Torterolo, P. (2018). Melanin-Concentrating Hormone in Medical Conditions. In: Pandi-Perumal, S., Torterolo, P., Monti, J. (eds) Melanin-Concentrating Hormone and Sleep . Springer, Cham. https://doi.org/10.1007/978-3-319-75765-0_10

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