Abstract
Cancer is a major public health problem all over the world. Increases in the number of individuals diagnosed with cancer each year, due in large part to aging and growth of the population, as well as improving detection and survival rates, have led to an ever-increasing number of cancer survivors. Various environmental, genetic and dietary factors play a role in cancer causation and prognosis. Advances in our understanding of the cellular and molecular basis of the gastrointestinal (GI) neoplasia have provided a foundation for the development of novel diagnostic and therapeutic approaches.Cancer takes a toll not only on the patients but also on the patients near and dear ones resulting in physical and psychological manifestations in the caregivers. Hence it is essential for the medical fraternity to employ a holistic and multi disciplinary approach in the management of cancer and its sequelae be it physical or psychological.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Feldman M, Friedman LS, Brandt LJ. Sleisenger and Fordtrans gastrointestinal and liver diseases. 9th ed. Philadelphia: Saunders; 2010.
Hayflick L. Mortality and immortality at the cellular level. A review. Biochemistry. 1997;62:1180–90.
Cech TR. Beginning to understand the end of the chromosome. Cell. 2004;116:273–9.
Thompson TC, Southgate J, Kitchener G, Land H. Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ. Cell. 1989;56:917–30.
Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest. 2007;117:1175–83.
Nowell PC. The clonal evolution of tumor cell populations. Science. 1976;194:23–8.
Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature. 1998;396:643–9.
Ozturk M. p53 mutations in nonmalignant human liver: fingerprints of aflatoxins? Hepatology. 1995;21:600–1.
Bortsch H. N-nitroso-compounds and human cancer: where do we stand? IARC Sci Publ. 1991;105:1–10.
Haenszel W, Kurihara M. Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States. J Natl Cancer Inst. 1968;40:43–68.
Mullan F. Seasons of survival: reflections of a physician with cancer. N Engl J Med. 1985;313:270–3.
Barbera L, Seow H, Howell D, et al. Symptom burden and performance status in a population-based cohort of ambulatory cancer patients. Cancer. 2010;116:5767–76.
Patrick DL, Ferketich SL, Frame PS, et al. National Institutes of Health State-of-the Science Panel. National Institutes of Health State-of-the-Science Conference Statement: symptom management in cancer: pain, depression, and fatigue, July 15–17, 2002. J Natl CancerInst Monogr. 2004;32:9–16.
Hofman M, Ryan JL, Figueroa-Moseley CD, Jean-Pierre P, Morrow GR. Cancer related fatigue: the scale of the problem. Oncologist. 2007;12(1):4–10.
van den Beuken-van Everdingen MH, de Rijke JM, Kessels AG, Schouten HC, van Kleef M, Patijn J. Prevalence of pain in patients with cancer: a systematic review of the past 40 years. Ann Oncol. 2007;18:1437–49.
World Health Organization. Cancer pain relief: with a guide to opioid availability. 2nd ed. Geneva, Switzerland: World Health Organization; 1996.
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology. Adult cancer pain. Version 2.2011. Fort Washington, PA: National Comprehensive Cancer Network; 2011.
Tipples K, Robinson A. Optimal management of cancer treatment-induced bone loss: considerations for elderly patients. Drugs Aging. 2011;28:867–83.
Steinherz LJ, Yahalom J. Cardiactoxicity. In: VT Jr DV, Hellman S, Rosenberg SA, editors. Cancer: principles and practice of oncology. 6th ed. Philadelphia, PA: Lippincott Williams&Wilkins; 2001. p. 2904–31.
Tukenova M, Guibout C, Oberlin O, et al. Role of cancer treatment in long-term overall and cardiovascular mortality after childhood cancer. J Clin Oncol. 2010;28:1308–15.
Ahles TA, Saykin A. Cognitive effects of standard-dose chemotherapy in patients withcancer. Cancer Investig. 2001;19:812–20.
Mitchell AJ, Chan M, Bhatti H, et al. Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies. Lancet Oncol. 2011;12:160–74.
Schover LR. Sexuality and fertility after cancer. Hematology Am Soc Hematol Educ Program. 2005:523–7. https://doi.org/10.1182/asheducation-2005.1.523.
Ganz PA, Desmond KA, Leedham B, Rowland JH, Meyerowitz BE, Belin TR. Quality of life in long-term, disease-free survivors of breast cancer: a follow-up study. J Natl Cancer Inst. 2002;94:39–49.
Courneya KS, Mackey JR, Bell GJ, Jones LW, Field CJ, Fairey AS. Randomized controlled trial of exercise training in postmenopausal breast cancer survivors: cardiopulmonary and quality of life outcomes. J Clin Oncol. 2003;21:1660–8.
Kushi LH, Byers T, Doyle C, et al. American Cancer Society 2006 Nutrition and Physical Activity Guidelines Advisory Committee. American Cancer Society Guidelines on Nutrition and Physical Activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin. 2006;56:254–81; quiz 313–314.
Burke L, Miller LA, Saad A, Abraham J. Smoking behaviors among cancer survivors: an observational clinical study. J Oncol Pract. 2009;5:6–9.
Yabroff KR, Kim Y. Time costs associated with informal caregiving for cancer survivors. Cancer. 2009;115(18):4362–73.
Hagedoorn M, Buunk BP, Kuijer RG, Wobbes T, Sanderman R. Couples dealing with cancer: role and gender differences regarding psychological distress and quality of life. Psychooncology. 2000;9:232–42.
Kim Y, Schulz R, Carver CS. Benefit-finding in the cancer caregiving experience. Psychosom Med. 2007;69:283–91.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Punnaveetil, S., Prabhakar, P. (2018). Medical Aspects of Gastrointestinal Cancer Etiology, Therapy, and Survivorship. In: Waly, M., Rahman, M. (eds) Bioactive Components, Diet and Medical Treatment in Cancer Prevention. Springer, Cham. https://doi.org/10.1007/978-3-319-75693-6_15
Download citation
DOI: https://doi.org/10.1007/978-3-319-75693-6_15
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-75692-9
Online ISBN: 978-3-319-75693-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)