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Kawasaki Disease

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Abstract

Kawasaki disease (KD) is an acute vasculitis leading to systemic inflammatory manifestations. The classic clinical criteria of KD include fever persisting at least 5 days and at least four out of five features (extremity changes, polymorphous exanthem, conjunctival injection, oral/lip changes, and cervical lymphadenopathy). Patients with KD will almost always have an elevated C-reactive protein and/or erythrocyte sedimentation rate. KD is treated with immunoglobulin and aspirin with the goal of preventing the development of coronary artery aneurysms.

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References

  1. Kawasaki T, Kosaki F, Okawa S, Shigematsu I, Yanagawa H. A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics. 1974;54:271–6.

    PubMed  CAS  Google Scholar 

  2. Singh S, Vignesh P, Burgner D. The epidemiology of Kawasaki disease: a global update. Arch Dis Child. 2015;100:1084–8.

    Article  PubMed  Google Scholar 

  3. Makino N, Nakamura Y, Yashiro M, et al. Descriptive epidemiology of Kawasaki disease in Japan, 2011–2012: from the results of the 22nd nationwide survey. J Epidemiol. 2015;25:239–45.

    Article  PubMed  Google Scholar 

  4. Callinan LS, Holman RC, Vugia DJ, Schonberger LB, Belay ED. Kawasaki disease hospitalization rate among children younger than 5 years in California, 2003–2010. Pediatr Infect Dis J. 2014;33:781–3.

    Article  PubMed  Google Scholar 

  5. Holman RC, Belay ED, Christensen KY, Folkema AM, Steiner CA, Schonberger LB. Hospitalizations for Kawasaki syndrome among children in the United States, 1997–2007. Pediatr Infect Dis J. 2010;29:483–8.

    PubMed  Google Scholar 

  6. Newburger JW, Takahashi M, Gerber MA, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Pediatrics. 2004;114:1708–33.

    Article  PubMed  Google Scholar 

  7. Minich LL, Sleeper LA, Atz AM, et al. Delayed diagnosis of Kawasaki disease: what are the risk factors? Pediatrics. 2007;120:e1434–40.

    Article  PubMed  Google Scholar 

  8. Chang FY, Hwang B, Chen SJ, Lee PC, Meng CC, Lu JH. Characteristics of Kawasaki disease in infants younger than six months of age. Pediatr Infect Dis J. 2006;25:241–4.

    Article  PubMed  Google Scholar 

  9. McCrindle BW, Rowley AH, Newburger JW, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association. Circulation. 2017;135:e927–e99.

    Article  PubMed  Google Scholar 

  10. Yellen ES, Gauvreau K, Takahashi M, et al. Performance of 2004 American Heart Association recommendations for treatment of Kawasaki disease. Pediatrics. 2010;125:e234–41.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Gong GW, McCrindle BW, Ching JC, Yeung RS. Arthritis presenting during the acute phase of Kawasaki disease. J Pediatr. 2006;148:800–5.

    Article  PubMed  Google Scholar 

  12. Uehara R, Igarashi H, Yashiro M, Nakamura Y, Yanagawa H. Kawasaki disease patients with redness or crust formation at the Bacille Calmette-Guerin inoculation site. Pediatr Infect Dis J. 2010;29:430–3.

    Article  PubMed  Google Scholar 

  13. Baker AL, Lu M, Minich LL, et al. Associated symptoms in the ten days before diagnosis of Kawasaki disease. J Pediatr. 2009;154:592–5 e2.

    Article  PubMed  Google Scholar 

  14. Turnier JL, Anderson MS, Heizer HR, Jone PN, Glode MP, Dominguez SR. Concurrent respiratory viruses and Kawasaki disease. Pediatrics. 2015;136:e609–14.

    Article  PubMed  Google Scholar 

  15. Cohen E, Sundel R. Kawasaki disease at 50 years. JAMA Pediatr. 2016;170:1093–9.

    Article  PubMed  Google Scholar 

  16. Lin YJ, Cheng MC, Lo MH, Chien SJ. Early differentiation of Kawasaki disease shock syndrome and toxic shock syndrome in a pediatric intensive care unit. Pediatr Infect Dis J. 2015;34:1163–7.

    Article  PubMed  Google Scholar 

  17. Kanegaye JT, Van Cott E, Tremoulet AH, et al. Lymph-node-first presentation of Kawasaki disease compared with bacterial cervical adenitis and typical Kawasaki disease. J Pediatr. 2013;162:1259–63, 63.e1-2.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Bayers S, Shulman ST, Paller AS. Kawasaki disease: part I. Diagnosis, clinical features, and pathogenesis. J Am Acad Dermatol. 2013;69:501 e1–11; quiz 11-2.

    Article  Google Scholar 

  19. Eladawy M, Dominguez SR, Anderson MS, Glode MP. Abnormal liver panel in acute Kawasaki disease. Pediatr Infect Dis J. 2011;30:141–4.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Tremoulet AH, Jain S, Chandrasekar D, Sun X, Sato Y, Burns JC. Evolution of laboratory values in patients with Kawasaki disease. Pediatr Infect Dis J. 2011;30:1022–6.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Shike H, Kanegaye JT, Best BM, Pancheri J, Burns JC. Pyuria associated with acute Kawasaki disease and fever from other causes. Pediatr Infect Dis J. 2009;28:440–3.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Printz BF, Sleeper LA, Newburger JW, et al. Noncoronary cardiac abnormalities are associated with coronary artery dilation and with laboratory inflammatory markers in acute Kawasaki disease. J Am Coll Cardiol. 2011;57:86–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Furusho K, Kamiya T, Nakano H, et al. High-dose intravenous gammaglobulin for Kawasaki disease. Lancet. 1984;2:1055–8.

    Article  CAS  PubMed  Google Scholar 

  24. Newburger JW, Takahashi M, Beiser AS, et al. A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki syndrome. N Engl J Med. 1991;324:1633–9.

    Article  CAS  PubMed  Google Scholar 

  25. Newburger JW, Takahashi M, Burns JC, et al. The treatment of Kawasaki syndrome with intravenous gamma globulin. N Engl J Med. 1986;315:341–7.

    Article  CAS  PubMed  Google Scholar 

  26. Kim GB, Yu JJ, Yoon KL, et al. Medium- or higher-dose acetylsalicylic acid for acute Kawasaki disease and patient outcomes. J Pediatr. 2017;184:125–9.e1.

    Article  CAS  PubMed  Google Scholar 

  27. Dallaire F, Fortier-Morissette Z, Blais S, et al. Aspirin dose and prevention of coronary abnormalities in Kawasaki disease. Pediatrics. 2017;139:e20170098.

    Article  PubMed  Google Scholar 

  28. Newburger JW, Sleeper LA, McCrindle BW, et al. Randomized trial of pulsed corticosteroid therapy for primary treatment of Kawasaki disease. N Engl J Med. 2007;356:663–75.

    Article  CAS  PubMed  Google Scholar 

  29. Kobayashi T, Saji T, Otani T, et al. Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial. Lancet. 2012;379:1613–20.

    Article  CAS  PubMed  Google Scholar 

  30. Wardle AJ, Connolly GM, Seager MJ, Tulloh RM. Corticosteroids for the treatment of Kawasaki disease in children. The Cochrane Database Syst Rev. 2017;1:Cd011188.

    Google Scholar 

  31. Chen S, Dong Y, Kiuchi MG, et al. Coronary artery complication in Kawasaki disease and the importance of early intervention : a systematic review and meta-analysis. JAMA Pediatr. 2016;170:1156–63.

    Article  PubMed  Google Scholar 

  32. Kanegaye JT, Wilder MS, Molkara D, et al. Recognition of a Kawasaki disease shock syndrome. Pediatrics. 2009;123:e783–9.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Dominguez SR, Friedman K, Seewald R, Anderson MS, Willis L, Glode MP. Kawasaki disease in a pediatric intensive care unit: a case-control study. Pediatrics. 2008;122:e786–90.

    Article  PubMed  Google Scholar 

  34. Chen PS, Chi H, Huang FY, Peng CC, Chen MR, Chiu NC. Clinical manifestations of Kawasaki disease shock syndrome: a case-control study. J Microbiol Immunol Infect = Wei mian yu gan ran za zhi. 2015;48:43–50.

    Article  CAS  PubMed  Google Scholar 

  35. Kato H, Sugimura T, Akagi T, et al. Long-term consequences of Kawasaki disease. A 10- to 21-year follow-up study of 594 patients. Circulation. 1996;94:1379–85.

    Article  CAS  PubMed  Google Scholar 

  36. Burns JC, Shike H, Gordon JB, Malhotra A, Schoenwetter M, Kawasaki T. Sequelae of Kawasaki disease in adolescents and young adults. J Am Coll Cardiol. 1996;28:253–7.

    Article  CAS  PubMed  Google Scholar 

  37. Salgado AP, Ashouri N, Berry EK, et al. High risk of coronary artery aneurysms in infants younger than 6 months of age with Kawasaki disease. J Pediatr. 2017;185:112–6.e1.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Tsuda E, Hamaoka K, Suzuki H, et al. A survey of the 3-decade outcome for patients with giant aneurysms caused by Kawasaki disease. Am Heart J. 2014;167:249–58.

    Article  PubMed  Google Scholar 

  39. Daniels LB, Tjajadi MS, Walford HH, et al. Prevalence of Kawasaki disease in young adults with suspected myocardial ischemia. Circulation. 2012;125:2447–53.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Nakamura Y, Aso E, Yashiro M, et al. Mortality among Japanese with a history of Kawasaki disease: results at the end of 2009. J Epidemiol. 2013;23:429–34.

    Article  PubMed  Google Scholar 

  41. Holve TJ, Patel A, Chau Q, Marks AR, Meadows A, Zaroff JG. Long-term cardiovascular outcomes in survivors of Kawasaki disease. Pediatrics. 2014;133:e305–11.

    Article  PubMed  Google Scholar 

  42. Garcia-Pavon S, Yamazaki-Nakashimada MA, Baez M, Borjas-Aguilar KL, Murata C. Kawasaki disease complicated with macrophage activation syndrome: a systematic review. J Pediatr Hematol Oncol. 2017;39:445–51.

    Article  PubMed  Google Scholar 

  43. Maddox RA, Holman RC, Uehara R, et al. Recurrent Kawasaki disease: USA and Japan. Pediatr Int Off J Jpn Pediatr Soc. 2015;57:1116–20.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Departments of Emergency Medicine and Pediatrics, University of California, San Diego School of Medicine, San Diego, CA, USA

    Paul Ishimine

  2. Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, CA, USA

    John T. Kanegaye

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  1. Paul Ishimine
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  2. John T. Kanegaye
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Correspondence to Paul Ishimine .

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Editors and Affiliations

  1. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Emily Rose

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Ishimine, P., Kanegaye, J.T. (2018). Kawasaki Disease. In: Rose, E. (eds) Life-Threatening Rashes. Springer, Cham. https://doi.org/10.1007/978-3-319-75623-3_7

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  • DOI: https://doi.org/10.1007/978-3-319-75623-3_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-75622-6

  • Online ISBN: 978-3-319-75623-3

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