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Surgery of Insular Diffuse Low-Grade Gliomas

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Island of Reil (Insula) in the Human Brain

Abstract

Diffuse low-grade glioma represents a premalignant neoplasm that has a propensity to involve the insula/paralimbic region for molecular, anatomical, and functional reasons. This tumor tends to affect young patients that present typically with few symptoms, most often epilepsy, but that exhibit neurocognitive deficits when screened appropriately by objective neuropsychological assessment. Because the natural history of this disease and the functional connectivity of this brain area are increasingly known, it has become clear that early and safe maximal surgical treatment is the best management in order to optimize not only survival but also quality of life of affected patients. We will here discuss insular gliomas as a specific pathologic entity; we will detail surgical techniques, by emphasizing the role of awake mapping; and we will report oncological as well as functional results of this therapeutic approach.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Enfant-Jésus Hospital, CHU de Québec, Laval University, Québec, QC, Canada

    Karine Michaud

  2. Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France

    Hugues Duffau M.D., Ph.D.

  3. Team “Plasticity of Central Nervous System, Stem Cells and Glial Tumors,” National Institute for Health and Medical Research (INSERM), U1051 Laboratory, Institute for Neurosciences of Montpellier, Montpellier University Medical Center, Montpellier, France

    Hugues Duffau M.D., Ph.D.

Authors
  1. Karine Michaud
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  2. Hugues Duffau M.D., Ph.D.
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Correspondence to Hugues Duffau M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Adnan Menderes University, School of Medicine , Aydın, Turkey

    Mehmet Turgut

  2. Ege University, Department of Anatomy, Izmir, Turkey

    Canan Yurttaş

  3. Seattle Science Foundation, Seattle, Washington, USA

    R. Shane Tubbs

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Michaud, K., Duffau, H. (2018). Surgery of Insular Diffuse Low-Grade Gliomas. In: Turgut, M., Yurttaş , C., Tubbs, R. (eds) Island of Reil (Insula) in the Human Brain. Springer, Cham. https://doi.org/10.1007/978-3-319-75468-0_28

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  • DOI: https://doi.org/10.1007/978-3-319-75468-0_28

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-75467-3

  • Online ISBN: 978-3-319-75468-0

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