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The Role of the Insula in Schizophrenia

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Island of Reil (Insula) in the Human Brain

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Abstract

Schizophrenia is a neuropsychiatric disorder characterized by broad cognitive and functional impairments, including deficits in executive attention, working memory, and social cognition, as well as the presence of delusional thinking and hallucinatory experiences. The insula is a target of structural alteration in schizophrenia, suffering losses in gray matter, white matter, and cortical surface area that correspond to abnormalities in its functional connectivity. Given the wide diversity of neurocognitive functions subserved by the insula, insular dysfunction may explain several symptoms of schizophrenia. We review here the morphometric and functional alterations of the insula over the course of schizophrenia and their relation to resulting neurological deficits.

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  1. Seattle Science Foundation, Seattle, WA, USA

    Cameron Schmidt

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  1. Adnan Menderes University, School of Medicine , Aydın, Turkey

    Mehmet Turgut

  2. Ege University, Department of Anatomy, Izmir, Turkey

    Canan Yurttaş

  3. Seattle Science Foundation, Seattle, Washington, USA

    R. Shane Tubbs

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Schmidt, C. (2018). The Role of the Insula in Schizophrenia. In: Turgut, M., Yurttaş , C., Tubbs, R. (eds) Island of Reil (Insula) in the Human Brain. Springer, Cham. https://doi.org/10.1007/978-3-319-75468-0_27

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