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Viral Manipulation of the Host Metabolic Network

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Metabolic Interaction in Infection

Part of the book series: Experientia Supplementum ((EXS,volume 109))

Abstract

Viruses are intracellular parasites that rely on host machinery to replicate and achieve a successful infection. Viruses have evolved to retain a broad range of strategies to manipulate host cell metabolism and metabolic resources, channeling them toward the production of virion components leading to viral production. Although several viruses share similar strategies for manipulating host cell metabolism, these processes depend on several factors, namely, the viral life cycle and the metabolic and energetic status of the infected cell. Based on this knowledge, the development of new therapeutic approaches that circumvent viral spread through the target of altered metabolic pathways is an opportunity to tackle the infection. However, finding effective broad-spectrum strategies that aim at restoring to homeostasis the metabolic alterations induced upon virus infection is still a Holy Grail quest for antiviral therapies. Here, we review the strategies by which viruses manipulate host metabolism for their own benefit, with a particular emphasis on carbohydrate, glutamine, and lipid metabolism.

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Authors and Affiliations

  1. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal

    Inês Mesquita

  2. ICVS/3B’s-PT Government Associate Laboratory, Braga, Guimarães, Portugal

    Inês Mesquita

  3. Centre de Recherche du CHU de Québec, Université Laval, Québec, Canada

    Jérôme Estaquier

  4. CNRS FR 3636, Université Paris Descartes, Paris, France

    Jérôme Estaquier

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  1. Inês Mesquita
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  2. Jérôme Estaquier
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Editors and Affiliations

  1. Life and Health Sciences Research Institute, University of Minho, Braga, Portugal

    Ricardo Silvestre

  2. Life and Health Sciences Research Institute, University of Minho, Braga, Portugal

    Egídio Torrado

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Mesquita, I., Estaquier, J. (2018). Viral Manipulation of the Host Metabolic Network. In: Silvestre, R., Torrado, E. (eds) Metabolic Interaction in Infection. Experientia Supplementum, vol 109. Springer, Cham. https://doi.org/10.1007/978-3-319-74932-7_10

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