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Systems Biology and Metabolic Modeling of C1-Metabolism

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Book cover Methane Biocatalysis: Paving the Way to Sustainability

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Abstract

Recent developments in experimental technologies have transformed traditional microbial physiology into a data-rich or -omics discipline. As a result, it has caused a renaissance of the mathematical analysis of biological systems and stimulated the development of systems biology workflows which aim to provide a holistic vision of all cellular functions through genomics, transcriptomics, proteomics, metabolomics, and fluxomic data. In silico modeling of metabolic systems has become a powerful tool, providing insight into the complex processes in cellular metabolism and their underlying regulatory mechanisms, as well as potentially improving the biotechnological design of microbial strains with desired properties. In this chapter, we provide an overview of the systems biology of methane utilization, as an example of one unique microbial function that has been dissected using - omics technologies. We discuss the most recent advances in large-scale investigation and computational representation of related metabolic networks as well as highlight some challenges for further developments in the field.

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Authors and Affiliations

  1. Department of Biology, San Diego State University, San Diego, CA, USA

    Ilya R. Akberdin, Merlin Thompson & Marina G. Kalyuzhnaya

  2. Viral Information Institute, San Diego State University, San Diego, CA, USA

    Marina G. Kalyuzhnaya

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  1. Ilya R. Akberdin
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  2. Merlin Thompson
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  3. Marina G. Kalyuzhnaya
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Correspondence to Marina G. Kalyuzhnaya .

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Editors and Affiliations

  1. Department of Biology, San Diego State University, San Diego, California, USA

    Marina G. Kalyuzhnaya

  2. Department of Chemical Engineering, Tsinghua University, Beijing, China

    Xin-Hui Xing

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Akberdin, I.R., Thompson, M., Kalyuzhnaya, M.G. (2018). Systems Biology and Metabolic Modeling of C1-Metabolism. In: Kalyuzhnaya, M., Xing, XH. (eds) Methane Biocatalysis: Paving the Way to Sustainability. Springer, Cham. https://doi.org/10.1007/978-3-319-74866-5_7

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