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Malignant Otitis Externa

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Abstract

Malignant otitis externa (MOE) is a rare, invasive infection of the temporal bone that arises in the external auditory canal. Most cases are due to Pseudomonas and occur in older diabetic patients. Untreated infection can extend to surrounding soft tissues and bones (temporomandibular joint , nasopharynx, petrous apex , skull base). The infection is subacute to chronic in presentation but potentially life-threatening. The correct diagnosis is often missed for weeks to months because the clinician is unfamiliar with the signs and symptoms of MOE. The high mortality rate seen in early series prompted the adjective “malignant,” but recent series have demonstrated that cure is possible in all cases if MOE is diagnosed early and treated appropriately. This chapter reviews the clinical features, diagnostic evaluation, and treatment of MOE.

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References

  1. Meltzer PE, Kelemen G. Pyocyaneous osteomyelitis of the temporal bone, mandible and zygoma. Laryngoscope. 1959;69:1300–16.

    Article  Google Scholar 

  2. Chandler JR. Malignant external otitis. Laryngoscope. 1968;78:1257–94.

    Article  CAS  PubMed  Google Scholar 

  3. Cohen D, Friedman P. The diagnostic criteria of malignant external otitis. J Laryngol Otol. 1987;101:216–21.

    Article  CAS  PubMed  Google Scholar 

  4. Sudhoff H, Rajagopal S, Mani N, et al. Usefulness of CT scans in malignant external otitis: effective tool for the diagnosis, but of limited value in predicting outcome. Eur Arch Otorhinolaryngol. 2008;265:53–6.

    Article  PubMed  Google Scholar 

  5. Stroman DW, Roland PS, Dohar J, Burt W. Microbiology of normal external auditory canal. Laryngoscope. 2001;111(11 Pt 1):2054–9.

    Article  CAS  PubMed  Google Scholar 

  6. Salit IE, Miller B, Wigmore M, Smith JA. Bacterial flora of the external canal in diabetics and non-diabetics. Laryngoscope. 1982;92(6 Pt 1):672–3.

    Article  CAS  PubMed  Google Scholar 

  7. Mena KD, Gerba CP. Risk assessment of Pseudomonas aeruginosa in water. Rev Environ Contam Toxicol. 2009;201:71–115.

    PubMed  CAS  Google Scholar 

  8. Walker J, Moore G. Pseudomonas aeruginosa in hospital water systems: biofilms, guidelines, and practicalities. J Hosp Infect. 2015;89:324–7.

    Article  CAS  PubMed  Google Scholar 

  9. Grandis J, Stoehr G, Yu VL, et al. Aural irrigation with water: a potential pathogenic mechanism for inducing malignant external otitis? Arch Otol Rhinol Laryngol. 1990;99:117–9.

    Article  Google Scholar 

  10. Zikk D, Rapoport Y, Himelfarb MZ. Invasive external otitis after removal of impacted cerumen by irrigation (letter). N Engl J Med. 1991;325:969–70.

    PubMed  CAS  Google Scholar 

  11. Ford GR, Courteney-Harris RG. Another hazard of ear syringing: malignant otitis externa. J Laryngol Otol. 1990;104:709–10.

    Article  CAS  PubMed  Google Scholar 

  12. Rubin J, Yu VL. Malignant external otitis: insights into pathogenesis, clinical manifestations, diagnosis, and therapy. Am J Med. 1988;85:391–8.

    Article  CAS  PubMed  Google Scholar 

  13. Hamzany Y, Soudry E, Preis M, et al. Fungal malignant external otitis. J Infect. 2011;62(3):226–31.

    Article  PubMed  Google Scholar 

  14. Al-Noury K, Lotfy A. Computed tomography and magnetic resonance imaging findings before and after treatment of patients with malignant external otitis. Eur Arch Otorhinolaryngol. 2011;268:1727–34.

    Article  PubMed  Google Scholar 

  15. Chen YA, Chan KC, Chen CK, Wu CM. Differential diagnosis and treatment of necrotizing otitis externa: a report of 19 cases. Auris Naris Larynx. 2011;28:666–70.

    Article  Google Scholar 

  16. Hobson CE, Moy JD, Byers KE, et al. Malignant otitis externa: evolving pathogens and implications for diagnosis and treatment. Otolaryngol Head Neck Surg. 2014;151:112–6.

    Article  PubMed  Google Scholar 

  17. Franco-Vidal V, Blanchet H, Bebear C, et al. Necrotizing external otitis: a report of 46 cases. Otol Neurotol. 2007;28:771–3.

    Article  PubMed  Google Scholar 

  18. Hariga I, Mardassi A, Belhaj Younes F, et al. Necrotizing otitis externa: 19 cases’ report. Eur Arch Otorhinolaryngol. 2010;267:1193–8.

    Article  PubMed  Google Scholar 

  19. Chin R, Roche P, Sigston E, Valance N. Malignant otitis externa: an Australian case series. Surgery. 2012;10:273–7.

    Google Scholar 

  20. Meade TK, Anari S, El Badawey MR, Zammit-Maempel I. Malignant otitis externa: case series. J Laryngol Otol. 2010;124:846–51.

    Article  PubMed  Google Scholar 

  21. Stevens SM, Lambert PR, Baker AB, Meyer TA. Malignant otitis externa: a novel stratification protocol for predicting treatment outcomes. Otol Neurotol. 2015;36:1492–8.

    Article  PubMed  Google Scholar 

  22. Pulcini C, Mahdyoun P, Cua E, et al. Antibiotic therapy in necrotizing external otitis: case series of 32 patients and review of the literature. Eur J Clin Microbiol Infect Dis. 2012;31:3287–94.

    Article  CAS  PubMed  Google Scholar 

  23. Lambor DV, Das CP, Goel HC, et al. Necrotising otitis externa: clinical profile and management protocol. J Laryngol Otol. 2013;127:1071–7.

    Article  CAS  PubMed  Google Scholar 

  24. Bhat V, Aziz A, Kumar Bhandary S, et al. Malignant otitis externa – a retrospective study of 15 patients treated in a tertiary healthcare center. Int Adv Otol. 2015;11:72–6.

    Article  Google Scholar 

  25. Loh S, Loh WS. Malignant otitis externa: an Asian perspective on treatment outcomes and prognostic factors. Otolaryngol Head Neck Surg. 2013;148:991–6.

    Article  PubMed  Google Scholar 

  26. Karaman E, Yilmaz M, Ibrahimov M, et al. Malignant otitis externa. J Craniofac Surg. 2012;23:1748–51.

    Article  PubMed  Google Scholar 

  27. Weinroth SE, Schessel D, Tuazon CU. Malignant otitis externa in AIDS patients: case report and review of the literature. Ear Nose Throat J. 1994;73:772–8.

    PubMed  CAS  Google Scholar 

  28. Rubin J, Yu VL, Stool SE. Malignant external otitis in children. J Pediatr. 1988;113:965–70.

    Article  CAS  PubMed  Google Scholar 

  29. Guerrero-Espejo A, Valenciano-Moreno I, Ramirez-Llorens R, Perez-Monteagudo P. Malignant otitis externa in Spain. Acta Otorrhinolaringol Esp. 2017;68:23–8.

    Article  Google Scholar 

  30. Sylvester MJ, Sanghvi S, Patel VM, et al. Malignant otitis externa hospitalizations: analysis of patient characteristics. Laryngoscope. 2017;127(10):2328–36.

    Article  PubMed  Google Scholar 

  31. Chawdhary G, Liow N, Democratis J, Whiteside O. Necrotising (malignant) otitis externa in the UK: a growing problem. Review of five cases and analysis of national Hospital Episode Statistics trends. J Laryngol Otol. 2015;129:600–3.

    Article  CAS  PubMed  Google Scholar 

  32. Mardinger O, Rosen D, Minkow B, et al. Temporomandibular joint involvement in malignant external otitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96:398–403.

    Article  PubMed  Google Scholar 

  33. Mani N, Sudhoff H, Rajagopal S, et al. Cranial nerve involvement in malignant external otitis: implications for clinical outcome. Laryngoscope. 2007;117:907–10.

    Article  PubMed  Google Scholar 

  34. Stern Shavit S, Soudry E, Hamzany Y, Nageris B. Malignant external otitis: factors predicting patient outcomes. Am J Otolaryngol. 2016;37:425–30.

    Article  PubMed  Google Scholar 

  35. Omran AA, El Garem HF, Al Alem RK. Recurrent malignant otitis externa: management and outcome. Eur Arch Otorhinolaryngol. 2012;269:807–11.

    Article  PubMed  Google Scholar 

  36. Walton J, Coulson C. Fungal malignant otitis externa with facial nerve palsy: tissue biopsy aids diagnosis. Case Rep Otolaryngol. 2014;2014:192318.

    PubMed  PubMed Central  Google Scholar 

  37. Mion M, Bovo R, Marchese-Ragona R, Martini A. Outcome predictors of treatment effectiveness for fungal malignant external otitis: a systematic review. Acta Otorhinolaryngol Ital. 2015;35:307–13.

    PubMed  PubMed Central  CAS  Google Scholar 

  38. McLaren O, Potter C. Scedosporium apiospermum: a rare cause of malignant otitis externa. BMJ Case Rep. 2016;2016:bcr2016217015.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Rubin J, Curtin HD, Yu VL, Kamerer DB. Malignant external otitis: utility of CT in diagnosis and follow up. Radiology. 1990;174:391–4.

    Article  CAS  PubMed  Google Scholar 

  40. Mattucci KF, Setzen M, Galantich P. Necrotizing otitis externa occurring concurrently with epidermoid carcinoma. Laryngoscope. 1986;96:264-266.

    Article  Google Scholar 

  41. Grandis JR, Hirsch BE, Yu VL. Simultaneous presentation of malignant external otitis and temporal bone cancer. Arch Otolaryngol Head Neck Surg. 1993;119:687–9.

    Article  CAS  PubMed  Google Scholar 

  42. al-Shihabi BA. Carcinoma of temporal bone presenting as malignant otitis externa. J Laryngol Otol. 1992;106(10):908.

    Article  CAS  PubMed  Google Scholar 

  43. Foden N, Burgess C, Damato S, Ramsden J. Concurrent necrotising otitis externa and adenocarcinoma of the temporal bone: a diagnostic challenge. BMJ Case Rep. 2013;2013:bcr2013009155. https://doi.org/10.1136/bcr-2013-009155.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Goh JPN, Karandikar A, Loke SC, Tan TY. Skull base osteomyelitis secondary to malignant otitis externa mimicking advanced nasopharyngeal cancer: MR imaging features at initial presentation. Am J Otolaryngol. 2017;38:466–71.

    Article  CAS  PubMed  Google Scholar 

  45. Herbrecht R, Denning DW, Patterson TF, et al. Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med. 2002;347:408–15.

    Article  CAS  PubMed  Google Scholar 

  46. Patterson TF, Thompson GR III, Denning DW, et al. Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;63(4):e1-e60.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Parize P, Chandesris MO, Lanternier F, et al. Antifungal therapy of Aspergillus invasive otitis externa: efficacy of voriconazole and review. Antimicrob Agents Chemother. 2009;53:1048–53.

    Article  CAS  PubMed  Google Scholar 

  48. Maertens JA, Raad II, Marr KA, et al. Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial. Lancet. 2016;387(10020):760–9.

    Article  CAS  PubMed  Google Scholar 

  49. Phillips JS, Jones SE. Hyperbaric oxygen as an adjuvant treatment for malignant otitis externa. Cochrane Database Syst Rev. 2013:CD004617.

    Google Scholar 

  50. Rubin J, Stoehr G, Yu VL, et al. Efficacy of oral ciprofloxacin plus rifampin for treatment of malignant external otitis. Arch Otolaryngol Head Neck Surg. 1989;115:1063–9.

    Article  CAS  PubMed  Google Scholar 

  51. Lang R, Goshen S, Kitzes-Cohen R, et al. Successful treatment of malignant external otitis with oral ciprofloxacin: report of experience with 23 patients. J Infect Dis. 1990;161:5357–540.

    Article  Google Scholar 

  52. Doroghazi RM, Nadol JB, Hyslop NE, et al. Invasive external otitis. Report of 21 cases and review of the literature. Am J Med. 1981;71:603–14.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Marlene L. Durand .

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Durand, M.L. (2018). Malignant Otitis Externa. In: Durand, M., Deschler, D. (eds) Infections of the Ears, Nose, Throat, and Sinuses. Springer, Cham. https://doi.org/10.1007/978-3-319-74835-1_10

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  • DOI: https://doi.org/10.1007/978-3-319-74835-1_10

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