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Diuretics in Heart Failure

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Ventricular-Assist Devices and Kidney Disease

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Abstract

Heart failure (HF) is a rapidly growing global pandemic. Despite advances in treatment, morbidity and mortality rates in the post-discharge period after an admission for acute decompensated heart failure (ADHF) remain unacceptably high. The mainstay of first line treatment is centered on diuretic therapy and fluid management. This chapter discusses the interactions between heart and kidney in HF, and focuses on the management of fluid overload. We discuss the mechanisms of diuretic resistance and its treatment. Recent trials performed on diuretic dosing and the comparisons of pharmacologic therapy to ultrafiltration are also reviewed.

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Authors and Affiliations

  1. Division of Nephrology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA

    Sarat Kuppachi & Mony Fraer

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  1. Sarat Kuppachi
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  2. Mony Fraer
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Correspondence to Sarat Kuppachi .

Editor information

Editors and Affiliations

  1. Director, Nephrology, Solid Organ Transplantation and Advanced Heart Failure Therapies, Advocate Christ Medical Center, University of Illinois, Oak Lawn, Illinois, USA

    Chaitanya Desai

  2. Clinical Associate Professor of Medicine University of Illinois, Clinical Director, Heart Transplantation and Mechanical Assistance, Advocate Christ Medical Center, Oak Lawn, Illinois, USA

    William G. Cotts

  3. Clinical Professor of Medicine, Section of Nephrology, University of Illinois at Chicago, College of Medicine, Advocate Christ Medical Center, Oak Lawn, Illinois, USA

    Edgar V. Lerma

  4. Associate Professor of Medicine, Division of Nephrology, Department of Medicine, Penn Presbyterian Medical Cente, Perleman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Michael R. Rudnick

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Kuppachi, S., Fraer, M. (2018). Diuretics in Heart Failure. In: Desai, C., Cotts, W., Lerma, E., Rudnick, M. (eds) Ventricular-Assist Devices and Kidney Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-74657-9_4

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