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The Emerging Roles of microRNAs in Stem Cell Aging

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Exosomes, Stem Cells and MicroRNA

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1056))

Abstract

Aging is the continuous loss of tissue and organ function over time. MicroRNAs (miRNAs) are thought to play a vital role in this process. miRNAs are endogenous small noncoding RNAs that control the expression of target mRNA. They are involved in many biological processes such as developmental timing, differentiation, cell death, stem cell proliferation and differentiation, immune response, aging and cancer. Accumulating studies in recent years suggest that miRNAs play crucial roles in stem cell division and differentiation. In the present chapter, we present a brief overview of these studies and discuss their contributions toward our understanding of the importance of miRNAs in normal and aged stem cell function in various model systems.

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Authors and Affiliations

  1. Stem Cell Regulation and Animal Aging Section, Basic Research Laboratory, National Cancer Institute, Frederick, MD, USA

    Catharine Dietrich & Shree Ram Singh

  2. Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA

    Manish Singh

  3. Hospitalist Division, Department of Medicine, Inova Fairfax Medical Campus, Falls Church, VA, USA

    Nishant Kumar

Authors
  1. Catharine Dietrich
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  2. Manish Singh
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  3. Nishant Kumar
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  4. Shree Ram Singh
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Corresponding author

Correspondence to Shree Ram Singh .

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Editors and Affiliations

  1. Cellastra Inc., San Francisco, California, USA

    Karl L. Mettinger

  2. Rutgers New Jersey Medical School, Newark, New Jersey, USA

    Pranela Rameshwar

  3. Novartis Pharmaceutical Corp., East Hanover, New Jersey, USA

    Vinod Kumar

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Dietrich, C., Singh, M., Kumar, N., Singh, S.R. (2018). The Emerging Roles of microRNAs in Stem Cell Aging. In: Mettinger, K., Rameshwar, P., Kumar, V. (eds) Exosomes, Stem Cells and MicroRNA. Advances in Experimental Medicine and Biology, vol 1056. Springer, Cham. https://doi.org/10.1007/978-3-319-74470-4_2

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