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The Impact of Pneumonectomy on the Right Ventricular Function

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Abstract

Notably, pulmonary resection is used in much pathology and more frequently during last years, especially due to the increased incidence of the cases diagnosed with lung cancer. Pulmonary resection surgery varies from the detachment of a lung region (atypical resections, segmentectomy, lobectomy or bilobectomy) to complete unilateral pulmonary removing (pneumonectomy). Left pneumonectomy is usually better tolerated than right pneumonectomy and some authors further said that “the right pneumonectomy was a disease itself”. Only that, this procedure has a proven impact on the heart function, particularly on the right ventricle performance. There is no doubt that pneumonectomy has consequences on the cardiac performance expressed by preload and afterload changes, as well as contractility adjustment by progressive dilatation of the right ventricle. Repercussions on the right ventricle function are the increase or reduction in volume or flow. Evaluation techniques are multiple but currently the mechanism of adaptation of the right ventricle to the conditions of pneumonectomy it is not precisely acknowledged. Deterioration of the right ventricle function begins after 6 months and is progressive to heart failure. Lobectomy and segmentectomy have fewer changes in the right ventricle performance due to the higher functional lung parenchyma remainder.

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References

  1. Evarts A, Graham MD, Singer JJ. Successful removal of an entire lung for carcinoma of the bronchus. JAMA. 1984;251:257–60.

    Article  Google Scholar 

  2. Wood DE. Pulmonary resection after pneumonectomy. Thorac Surg Clin. 2004;14(2):173–82. https://doi.org/10.1016/S1547-4127(04)00006-4.

    Article  PubMed  Google Scholar 

  3. Jensik RL, Faber LP, Milloy FJ, et al. Segmental resection for lung cancer. A 15-year experience. J Thorac Cardiovasc Surg. 1973;66:563–72.

    PubMed  CAS  Google Scholar 

  4. Thomas CP. The present position relating to cancer of the lung. Lobectomy with sleeve resection. Thorax. 1960;15:9–11.

    PubMed  CAS  Google Scholar 

  5. Shields TW, LoCicero J III, Ponn RB, Daly BDT. Surgical treatment of non-small cell lung cancer. In: Shields TW, LoCicero J, Ponn RB, et al., editors. General thoracic surgery. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2009. p. 1311–41. ISBN: 0781779820.

    Google Scholar 

  6. Lang-Lazdunski L. Surgery for nonsmall cell lung cancer. Eur Respir Rev. 2013;22(129):382–404. https://doi.org/10.1183/09059180.00003913.

    Article  PubMed  Google Scholar 

  7. Gill Cryer H, Mavroudis C, Yu J, Roberts AM, Cue JI, Richardson JD, Polk HC. Shock, transfusion and pneumonectomy. Ann Surg. 1990;212:197–201.

    Article  Google Scholar 

  8. Lewis JW Jr, Gabriel F, Bastanfar M, Servin J. Right ventricular performance in patients undergoing pneumonectomy. Chest. 1992;102:63S–7S.

    Article  Google Scholar 

  9. Okada M, Okada M, Ishi N, Yamashita C, Sugimoto T, Okada K, Yamagishi H, et al. Right ventricular ejection fraction in the preoperative risk evaluation of candidates for pulmonary resection. J Thorac Cardiovasc Surg. 1996;112:364–70.

    Article  CAS  PubMed  Google Scholar 

  10. Reed CE, Spinale FG, Crawford FA Jr. Effect of pulmonary resection on right ventricular function. Ann Thorac Surg. 1992;53:578–82.

    Article  CAS  PubMed  Google Scholar 

  11. Rivera C, Arame A, Pricopi C, Riquet M, Mangiameli G, Abdennadher M, Dahan M, Le Pimpec Barthes F. Pneumonectomy for benign disease: indications and postoperative outcomes, a nationwide study. Eur J Cardiothorac Surg. 2015;48(3):435–40. ; discussion 440. https://doi.org/10.1093/ejcts/ezu439.

    Article  PubMed  Google Scholar 

  12. Conlan AA, Kopecf SE. Indications for pneumonectomy: pneumonectomy for benign disease. Chest Surg Clin N Am. 1999;9:311–26.

    PubMed  CAS  Google Scholar 

  13. Lim E, Baldwin D, Beckles M, et al. Guidelines on the radical management of patients with lung cancer. Thorax. 2010;65(Suppl 3):iii1–iii27.

    Article  PubMed  Google Scholar 

  14. Shapiro M, Swanson SJ, Wright CD, et al. Predictors of major morbidity and mortality after pneumonectomy utilizing the Society for Thoracic Surgeons General Thoracic Surgery Database. Ann Thorac Surg. 2010;90:927–34.

    Article  PubMed  Google Scholar 

  15. Berrisford R, Brunelli A, Rocco G, et al. The European Thoracic Surgery Database project: modelling the risk of inhospital death following lung resection. Eur J Cardiothorac Surg. 2005;28:306–11.

    Article  PubMed  Google Scholar 

  16. Harpole DH Jr, DeCamp MM Jr, Daley J, et al. Prognostic models of thirty-day mortality and morbidity after major pulmonary resection. J Thorac Cardiovasc Surg. 1999;117:969–79.

    Article  PubMed  Google Scholar 

  17. Falcoz PE, Conti M, Brouchet L, et al. The thoracic surgery scoring system (THORACOSCORE): risk model for inhospital death in 15,183 patients requiring thoracic surgery. J Thorac Cardiovasc Surg. 2007;133:325–32.

    Article  PubMed  Google Scholar 

  18. Kozower BD, Sheng S, O’Brien SM, et al. STS database risk models: predictors of mortality and major morbidity for lung cancer resction. Ann Thorac Surg. 2010;90:875–81.

    Article  PubMed  Google Scholar 

  19. Sawabata N, Nagayasu T, Kadota Y, Goto T, Horio H, Mori T, Yamashita S, Iwasaki A. Risk assessment of lung resection for lung cancer according to pulmonary function: republication of systematic review and proposals by guideline committee of the Japanese association for chest surgery 2014. Gen Thorac Cardiovasc Surg. 2015;63(1):14–21. https://doi.org/10.1007/s11748-014-0475-x.

    Article  PubMed  Google Scholar 

  20. Gaballo A, Corbo GM, Valente S, Ciappi G. Preoperative evaluation and risk factors of lung cancer. Rays. 2004;29(4):391–400.

    PubMed  Google Scholar 

  21. Armstrong P, Congleton J, Fountain SW, et al. BTS guidelines: guidelines on the selection of patients with lung cancer for surgery. Thorax. 2001;56:89–108.

    Article  Google Scholar 

  22. Beckles MA, Spiro SG, Colice GL, et al. The physiologic evaluation of patients with lung cancer being considered for resectional surgery. Chest. 2003;123(Suppl 1):105S–14S.

    Article  PubMed  Google Scholar 

  23. Ferguson MK, Vigneswaran WT. Diffusing capacity predicts morbidity after lung resection in patients without obstructive lung disease. Ann Thorac Surg. 2008;85:1158–64.

    Article  PubMed  Google Scholar 

  24. Beattie GW, Dunn WG, Asif M. In patients with a tumour invading the phrenic nerve does prophylactic diaphragm plication improve postoperative lung function? Interact Cardiovasc Thorac Surg. 2016;23(3):454–8. https://doi.org/10.1093/icvts/ivw091.

    Article  PubMed  Google Scholar 

  25. Ueda K, Hayashi M, Tanaka N, Tanaka T, Hamano K. Long-term pulmonary function after major lung resection. Gen Thorac Cardiovasc Surg. 2014;62(1):24–30. https://doi.org/10.1007/s11748-013-0346-x.

    Article  PubMed  Google Scholar 

  26. Miserocchi G, Beretta E, Rivolta I. Respiratory mechanics and fluid dynamics after lung resection surgery. Thorac Surg Clin. 2010;20(3):345–57. https://doi.org/10.1016/j.thorsurg.2010.03.001.

    Article  PubMed  Google Scholar 

  27. Kometani T, Okamoto T, Yoshida S, Yoshino I. Acute respiratory distress syndrome after pulmonary resection. Gen Thorac Cardiovasc Surg. 2013;61(9):504–12. doi:https://doi.org/10.1007/s11748-013-0276-7

    Article  PubMed  Google Scholar 

  28. Darling GE, Abdurahman A, Yi QL, et al. Risk of a right pneumonectomy: role of bronchopleural fistula. Ann Thorac Surg. 2005;79:433–7.

    Article  PubMed  Google Scholar 

  29. Schirren J, Eberlein M, Fischer A, et al. The role of sleeve resections in advanced nodal disease. Eur J Cardiothorac Surg. 2011;40:1157–63.

    PubMed  Google Scholar 

  30. Lv C, Ma Y, Wu N, Yan S, Zheng Q, Sun Y, Li S, Fang J, Yang Y. A retrospective study: platinum-based induction chemotherapy combined with gemcitabine or paclitaxel for stage IIB-IIIA central non-small-cell lung cancer. World J Surg Oncol. 2013;11:76. https://doi.org/10.1186/1477-7819-11-76.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Schirren J, Bolukbas S, Bergmann T, et al. Prospective study on perioperative risks and functional results in bronchial and bronchovascular sleeve resections. Thorac Cardiovasc Surg. 2009;57:35–41.

    Article  CAS  PubMed  Google Scholar 

  32. Tronc F, Gregoire J, Rouleau J, et al. Long-term results of sleeve lobectomy for lung cancer. Eur J Cardiothorac Surg. 2000;17:550–6.

    Article  CAS  PubMed  Google Scholar 

  33. Yildizeli B, Fadel E, Mussot S, et al. Morbidity, mortality and long-term survival after sleeve lobectomy for nonsmall cell lung cancer. Eur J Cardiothorac Surg. 2007;31:95–102.

    Article  PubMed  Google Scholar 

  34. Fields RC, Meyers BF. Sublobar resections for lung cancer. Semin Thorac Cardiovasc Surg. 2006;18(2):85–91.

    Article  PubMed  Google Scholar 

  35. Treasure T, Utley M, Bailey A. Assessment of whether in-hospital mortality for lobectomy is a useful standard for the quality of lung cancer surgery: retrospective study. BMJ. 2003;327:73.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Gharagozloo F, Margolis M, Tempesta B, et al. Robot-assisted lobectomy for early-stage lung cancer: report of 100 consecutive cases. Ann Thorac Surg. 2009;88:380–4.

    Article  PubMed  Google Scholar 

  37. Park BJ, Melfi F, Mussi A, et al. Robotic lobectomy for non-small cell lung cancer (NSCLC): long-term oncologic results. J Thorac Cardiovasc Surg. 2012;143:383–9.

    Article  PubMed  Google Scholar 

  38. Park BJ, Flores RM. Cost comparison of robotic, video-assisted thoracic surgery and thoracotomy approaches to pulmonary lobectomy. Thorac Surg Clin. 2008;18:297–300.

    Article  PubMed  Google Scholar 

  39. Fleisher LA, Beckman JA, Brown KA, et al. ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for non-cardiac surgery: a report of the American College of cardiology/American Heart Association task force on practice guidelines. J Am Coll Cardiol. 2007;50:e159–242.

    Article  PubMed  Google Scholar 

  40. Yang CF, D’Amico TA. Thoracoscopic segmentectomy for lung cancer. Ann Thorac Surg. 2012;94:668–81.

    Article  PubMed  Google Scholar 

  41. Mun M, Kohno T. Efficacy of thoracoscopic resection for multifocal bronchioloalveolar carcinoma showing pure ground-glass opacities of 20 mm or less in diameter. J Thorac Cardiovasc Surg. 2007;134:877–82.

    Article  PubMed  Google Scholar 

  42. Nakata M, Sawada S, Yamashita M, et al. Surgical treatments for multiple primary adenocarcinoma of the lung. Ann Thorac Surg. 2004;78:1194–9.

    Article  PubMed  Google Scholar 

  43. Sugarbaker DJ, Jaklitsch MT, Bueno R, et al. Prevention, early detection, and management of complications after 328 consecutive extrapleural pneumonectomies. J Thorac Cardiovasc Surg. 2004;128(1):138–46. https://doi.org/10.1016/j.jtcvs.2004.02.021.

    Article  PubMed  Google Scholar 

  44. Walker WS, Leaver HA. Immunologic and stress responses following video-assisted thoracic surgery and open pulmonary lobectomy in early stage lung cancer. Thorac Surg Clin. 2007;17:241–9.

    Article  PubMed  Google Scholar 

  45. Flores RM, Park BJ, Dycoco J, et al. Lobectomy by video-assisted thoracic surgery (VATS ) versus thoracotomy for lung cancer. J Thorac Cardiovasc Surg. 2009;138:11–8.

    Article  PubMed  Google Scholar 

  46. Whitson BA, Groth SS, Duval SJ, et al. Surgery for early-stage non-small cell lung cancer: a systematic review of the video-assisted thoracoscopic surgery versus thoracotomy approaches to lobectomy. Ann Thorac Surg. 2008;86:2016–8.

    Google Scholar 

  47. Yan TD, Black D, Bannon PG, et al. Systematic review and meta-analysis of randomized and non-randomized trials on safety and efficacy of video-assisted thoracic surgery lobectomy for early stage non-small-cell lung cancer. J Clin Oncol. 2009;27:2553–62.

    Article  PubMed  Google Scholar 

  48. Cattaneo SM, Park BJ, Wilton AS, et al. Use of video-assisted thoracic surgery for lobectomy in the elderly results in fewer complications. Ann Thorac Surg. 2008;85:231–5.

    Article  PubMed  Google Scholar 

  49. Wolf AS, Richards WG, Jaklitsch MT, et al. Lobectomy versus sublobar resection for small (2 cm or less) non-small cell lung cancers. Ann Thorac Surg. 2011;92:1819–23.

    Article  PubMed  Google Scholar 

  50. Petersen RP, Pham D, Burfeind WR, et al. Thoracoscopic lobectomy facilitates the delivery of chemotherapy after resection for lung cancer. Ann Thorac Surg. 2007;83:1245–9.

    Article  PubMed  Google Scholar 

  51. Rocco G. One-port (uniportal) video-assisted thoracic surgical resections – a clear advance. J Thorac Cardiovasc Surg. 2012;144:S27–31.

    Article  PubMed  Google Scholar 

  52. Gonzales-Rivas D, Paradela M, Fernandez R, et al. Uniportal video-assisted thoracoscopic lobectomy: two years of experience. Ann Thorac Surg. 2013;95:426–32.

    Article  Google Scholar 

  53. Emmert A, Straube C, Buentzel J, Roever C. Robotic versus thoracoscopic lung resection: a systematic review and meta-analysis. Medicine (Baltimore). 2017;96(35):e7633. https://doi.org/10.1097/MD.0000000000007633.

    Article  Google Scholar 

  54. Stiles QR, Meyer BW, Lindesmith GG, et al. The effects of pneumonectomy in children. J Thorac Cardiovasc Surg. 1969;58:394–400.

    PubMed  CAS  Google Scholar 

  55. Werner HA, Pirie GE, Nadel HR, et al. Lung volumes, mechanics and perfusion after pulmonary resection in infancy. J Thorac Cardiovasc Surg. 1993;105:737–42.

    PubMed  CAS  Google Scholar 

  56. Laros CD, Westermann CJJ. Dilatation, compensatory growth, or both after pneumonectomy during childhood and adolescence. J Thorac Cardiovasc Surg. 1987;93:570–6.

    PubMed  CAS  Google Scholar 

  57. Smulders SA, Holverda S, Vonk-Noordegraaf A, van den Bosch HC, Post JC, Marcus JT, Smeenk FW, Postmus PE. Cardiac function and position more than 5 years after pneumonectomy. Ann Thorac Surg. 2007;83(6):1986–92. https://doi.org/10.1016/j.athoracsur.2007.01.036.

    Article  PubMed  Google Scholar 

  58. Wang Z, Yuan J, Chu W, Kou Y, Zhang X. Evaluation of left and right ventricular myocardial function after lung resection using speckle tracking echocardiography. Medicine (Baltimore). 2016;95(31):e4290. https://doi.org/10.1097/MD.0000000000004290.

    Article  Google Scholar 

  59. Foroulis CN, Kotoulas CS, Kakouros S, Evangelatos G, Chassapis C, Konstantinou M, Lioulias AG. Study on the late effect of pneumonectomy on right heart pressures using Doppler echocardiography. Eur J Cardiothorac Surg. 2004;26:508–14. https://doi.org/10.1016/j.ejcts.2004.05.036

    Article  PubMed  Google Scholar 

  60. Schulman DS, Matthay RA. The right ventricle in pulmonary disease. Cardiol Clin. 1992;10:111–35.

    Article  PubMed  CAS  Google Scholar 

  61. Van Mieghem W, Demedts M. Cardiopulmonary function after lobectomy or pneumonectomy for pulmonary neoplasm. Respir Med. 1989;83:199–206.

    Article  PubMed  Google Scholar 

  62. Çölkesen Y, Açıl T, Fındıkçıoglu A, et al. Tissue Doppler evaluation of the effects of major lung resection on cardiac functions. Turk Kardiyol Dern Ars. 2009;37:317–20.

    PubMed  Google Scholar 

  63. Nojiri T, Maeda H, Takeuchi Y, et al. Predictive value of preoperative tissue Doppler echocardiographic analysis for postoperative atrial fibrillation after pulmonary resection for lung cancer. J Thorac Cardiovasc Surg. 2010;140:764–8.

    Article  PubMed  Google Scholar 

  64. Kowalewski J, Brocki M, Dryjanski T, Kapron K, Barcikowski S. Right ventricular morphology and function after pulmonary resection. Eur J Cardiothorac Surg. 1999;15:444–8.

    Article  CAS  PubMed  Google Scholar 

  65. Okada M, Ota T, Okada M, Matsuda H, Okada K, Ishii N. Right ventricular dysfunction after major pulmonary resection. J Thorac Cardiovasc Surg. 1994;108:503–11.

    PubMed  CAS  Google Scholar 

  66. Mitsudomi T, Mizoue T, Yoshimatsu T, Oyama T, Nakanishi R, Okabayashi K, Osaki T, Kume T, Yasumoto K. Sugimac postoperative complications after pneumonectomy for treatment of lung cancer: multivariate analysis. J Surg Oncol. 1996;61:218.

    Article  CAS  PubMed  Google Scholar 

  67. Rudski LG, Lai WW, Afilalo J, et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr. 2010;23:685–713.

    Article  PubMed  Google Scholar 

  68. Amar D, Burt ME, Roistacher N, et al. Value of perioperative Doppler echocardiography in patients undergoing major lung resection. Ann Thorac Surg. 1996;61:516–20.

    Article  CAS  PubMed  Google Scholar 

  69. Pedoto A, Amar D. Right heart function in thoracic surgery: role of echocardiography. Curr Opin Anesthesiol. 2009;22:44–9.

    Article  Google Scholar 

  70. Roscher C, Reidy C, Augoustides JG. Progress in perioperative echocardiography: focus on safety, clinical outcomes, 3-dimensional imaging, and education. J Cardiothorac Vasc Anesth. 2011;25:559–64.

    Article  PubMed  Google Scholar 

  71. Sahn DJ, Zhang J, Tam L, et al. Evaluation of right ventricular mechanics with 4D echocardiography: an in vitro validation against sonomicrometry. J Am Coll Cardiol. 2013;61(Suppl 10):E892.

    Article  Google Scholar 

  72. Yu HK, Li SJ, Ip JJ, et al. Right ventricular mechanics in adults after surgical repair of tetralogy of Fallot: insights from three-dimensional speckle-tracking echocardiography. J Am Soc Echocardiogr. 2014;27:423–9.

    Article  PubMed  Google Scholar 

  73. Greyson CR. Evaluation of right ventricular function. Curr Cardiol Rep. 2011;13(3):194–202.

    Article  PubMed  Google Scholar 

  74. Vainshelboim B, Fox BD, Saute M, et al. Limitations in exercise and functional capacity in long-term postpneumonectomy patients. J Cardiopulmon Rehabil Prevent. 2015;35:56–64.

    Article  Google Scholar 

  75. Leitman M, Lysyansky P, Sidenko S, et al. Two-dimensional strain: a novel software for real-time quantitative echocardiographic assessment of myocardial function. J Am Soc Echocardiogr. 2004;17:1021–9.

    Article  PubMed  Google Scholar 

  76. Venuta F, Sciomer S, Andreetti C, Anile M, De Giacomo T, Rolla M, Fedele F, Coloni GF. Long-term Doppler echocardiographic evaluation of the right heart after major lung resections. Eur J Cardiothorac Surg. 2007;32(5):787–90. https://doi.org/10.1016/j.ejcts.2007.07.033.

    Article  PubMed  Google Scholar 

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Nistor, C., Ciuche, A., Săvoiu, D., Batog, O., Bontaş, E. (2018). The Impact of Pneumonectomy on the Right Ventricular Function. In: Dumitrescu, S., Ţintoiu, I., Underwood, M. (eds) Right Heart Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-73764-5_51

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