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Right Heart Involvement in Haematologic Disorders

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Abstract

Haematologic patients are set apart by specific complications like immunosuppression, thrombocytopenia, sometimes associating coagulopathy and multiple points of entry for infection (central venous catheters and mucositis).

The right-sided heart is of particular importance in this type of patients as it is the preferred location of both primary and secondary cardiac tumours and is more frequently affected by radiation therapy due to its more anterior position in the thorax.

Chemotherapeutics may determine pulmonary hypertension and thus put a strain on the right ventricle.

Moreover, investigation of right-heart parameters like tricuspid annular plane systolic excursion and strain rate may reveal early cardiac dysfunction and establish prognosis in cardiac amyloidosis.

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Notes

  1. 1.

    The isointensity to normal myocardium on T1 and T2-weighted imaging and heterogeneity of enhancement on MRI are unique to PCL. Furthermore, MRI has the advantage of being able to differentiate between primary cardiac tumors: cardiac lipomas have high signal intensity on T1-weighted and intermediate signal on T2-weighted imaging (similar to mediastinal fat on MRI), fibromas have low signal intensity on T1 and T2 -weighted sequences (consistent with fibrous tissue), and pericardial cysts have low T1 signal intensity and high T2 signal intensity (as is the case with simple fluid).

  2. 2.

    As lymphoma and breast and gastric cancer usually respond to similar chemotherapy regimens and/or radiation therapy, the two entities have most commonly been studied together.

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Authors and Affiliations

  1. Department of Internal Medicine, Colţea Clinical Hospital, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

    Ana-Maria Vintilă

  2. Department of Internal Medicine, Colţea Clinical Hospital, Bucharest, Romania

    Mihaela Horumbă

  3. Department of Cardiology, University Emergency Hospital, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

    Vlad Damian Vintilă

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  1. Ana-Maria Vintilă
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  2. Mihaela Horumbă
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  3. Vlad Damian Vintilă
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  1. Department of Medicine, Titu Maiorescu University, Bucharest, Romania

    Silviu Ionel Dumitrescu

  2. Department of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

    Ion C. Ţintoiu

  3. Department of Surgery, Chinese University of Hong Kong, Sha Tin, Hong Kong

    Malcolm John Underwood

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Vintilă, AM., Horumbă, M., Vintilă, V.D. (2018). Right Heart Involvement in Haematologic Disorders. In: Dumitrescu, S., Ţintoiu, I., Underwood, M. (eds) Right Heart Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-73764-5_27

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