Abstract
Pharmacologic therapy is fundamental to the treatment of cardiac emergencies in children. Unfortunately, as with most drug therapy in children, little data exists as to optimal application of therapeutic agents. Therefore, a sound understanding of developmental physiology and pharmacology is necessary. In this chapter, we offer a succinct review of developmental physiology and pharmacology relevant to drug therapy and a concise overview of the application of the most relevant drugs.
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References
Allen HD. Moss and Adams heart disease in infants, children, and adolescents: including the fetus and young adult, vol. 2. 8th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2013.
Guyton AC, Hall JE. Textbook of medical physiology, vol. xxxv. 11th ed. Philadelphia: Elsevier Saunders; 2006. 1116 p
Katz AM, Smith VE. Regulation of myocardial function in the normal and diseased heart. Modification by inotropic drugs. Eur Heart J. 1982;3 Suppl D:11–8.
Ghali MGZ. Role of the medullary lateral tegmental field in sympathetic control. J Integr Neurosci. 2017;16(2):189–208.
Cody RJ. The integrated effects of angiotensin II. Am J Cardiol. 1997;79(5A):9–11.
Takayama Y, Costa KD, Covell JW. Contribution of laminar myofiber architecture to load-dependent changes in mechanics of LV myocardium. Am J Physiol Heart Circ Physiol. 2002;282(4):H1510–20.
Adhyapak SM, Parachuri VR. Architecture of the left ventricle: insights for optimal surgical ventricular restoration. Heart Fail Rev. 2010;15(1):73–83.
Robinson RB. Autonomic receptor--effector coupling during post-natal development. Cardiovasc Res. 1996;31 Spec No:E68–76.
Clyman RI. Mechanisms regulating the ductus arteriosus. Biol Neonate. 2006;89(4):330–5.
Myburgh JA, Mythen MG. Resuscitation fluids. N Engl J Med. 2013;369(25):2462–3.
Kho TL, et al. Influence of dobutamine and dopamine on hemodynamics and plasma concentrations of noradrenaline and renin in patients with low cardiac output following acute myocardial infarction. Eur J Clin Pharmacol. 1980;18(3):213–7.
Jaski BE, et al. Positive inotropic and vasodilator actions of milrinone in patients with severe congestive heart failure. Dose-response relationships and comparison to nitroprusside. J Clin Invest. 1985;75(2):643–9.
Hoffman TM, et al. Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. Circulation. 2003;107(7):996–1002.
De Luca L, et al. Evidence-based use of levosimendan in different clinical settings. Eur Heart J. 2006;27(16):1908–20.
Ignarro LJ, et al. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther. 1981;218(3):739–49.
Overholt ED, et al. Usefulness of adenosine for arrhythmias in infants and children. Am J Cardiol. 1988;61(4):336–40.
Reynolds RD, Gorczynski RJ, Quon CY. Pharmacology and pharmacokinetics of esmolol. J Clin Pharmacol. 1986;26 Suppl A:A3–A14.
Singh BN. Amiodarone: historical development and pharmacologic profile. Am Heart J. 1983;106(4 Pt 2):788–97.
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Clark, J., Tilford, B. (2018). Cardiac Pharmacology. In: Sarnaik, A., Ross, R., Lipshultz, S., Walters III, H. (eds) Cardiac Emergencies in Children. Springer, Cham. https://doi.org/10.1007/978-3-319-73754-6_7
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DOI: https://doi.org/10.1007/978-3-319-73754-6_7
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