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Heat Shock Proteins in Leptospirosis

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Heat Shock Proteins in Veterinary Medicine and Sciences

Part of the book series: Heat Shock Proteins ((HESP,volume 12))

Abstract

Leptospirosis caused by pathogenic Leptospira spirochetes remains an important zoonotic disease worldwide. Like many other dimorphic bacterial pathogens, leptospires have abilities to adapt themselves to survive in a wide range of environmental conditions outside and inside the infected hosts. Recent investigations using genomics and proteomics approaches have revealed that several heat shock proteins (HSP) encoded by the conserved immunodominant antigenic region of Hsp genes among the pathogenic leptospires are associated with their adaption to survive, infectivity and virulence. Understanding how HSP are differentially expressed and regulated during leptospiral infection is thus crucial to develop better serodiagnostic test and vaccine for clinical use. This chapter summarizes the current knowledge of HSP expression and their roles in leptospirosis and also extensively discusses future perspectives of this arena to battle leptospirosis with the ultimate goals for better therapeutic outcome and successful prevention.

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Abbreviations

APC:

Antigen presenting cells

HSP:

Heat shock proteins

LPS:

Lipopolysaccharide

MAT:

Microscopic agglutination test

MHC:

Major histocompatibility complex

MS:

Mass spectrometry

OMPs:

Outer-membrane proteins

sHSP:

Small heat shock proteins

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Acknowledgements

This work was supported by Mahidol University research grant and the Thailand Research Fund (IRN60W0004 and IRG5980006).

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Authors and Affiliations

  1. Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Arada Vinaiphat & Visith Thongboonkerd

Authors
  1. Arada Vinaiphat
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  2. Visith Thongboonkerd
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Correspondence to Visith Thongboonkerd .

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Editors and Affiliations

  1. Professor, Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center University of Toledo College of Medicine and Life Sciences, Toledo, USA

    Alexzander A. A. Asea

  2. Visiting Scientist Professor, Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA

    Punit Kaur

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Vinaiphat, A., Thongboonkerd, V. (2017). Heat Shock Proteins in Leptospirosis. In: Asea, A., Kaur, P. (eds) Heat Shock Proteins in Veterinary Medicine and Sciences. Heat Shock Proteins, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-319-73377-7_14

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