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Ovarian Cancer: Current Applications of Minimally Invasive Techniques

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Minimally Invasive Gynecology

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Abstract

In developed countries, ovarian cancer is the second most frequent cancer of the female genital tract and is certainly the most lethal [1]. The incidence and the mortality related to this neoplasm have significantly increased over the last decades, and it will certainly constitute a major healthcare problem in the near future [2]. It is estimated that 125,000 women worldwide die each year due to this condition [3]. Despite a number of screening efforts, approximately 75% of patients are diagnosed with advanced forms of the disease (advanced ovarian cancer, AOC) [4]. In fact, surgery represents the cornerstone of treatment for this condition, and diverse studies have clearly demonstrated that achievement of complete cytoreduction (no macroscopic residual tumor) has a substantial impact on survival [5, 6]. Unfortunately, due to the magnitude of disease dissemination, only in about 20–50% of the patients with AOC is primary optimal debulking surgery technically possible [4, 6, 7]. In this scenario, alternative strategies such as neoadjuvant chemotherapy (NACT), leading to higher rates of adequate resection, may be beneficial to a number of patients who are initially considered inoperable [4, 8]. The recent introduction into clinical practice of NACT for AOC, coupled with the development of modern technology and an increased number of skilled laparoscopic surgeons, has created a more favorable scenario for endoscopic debulking, at least in selected cases. However, there is currently a notorious paucity of data regarding the feasibility and oncologic safety of this new strategy.

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Authors and Affiliations

  1. Department of Gynecology, Instituto do Câncer do Estado de São Paulo – ICESP Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Giovanni Favero M.D., Ph.D., Alexandre Silva e Silva M.D. & Jesus Paula Carvalho M.D., Ph.D.

  2. Department of Advanced Gynecologic Surgery and Oncology, Asklepios Hospital Hamburg, Hamburg, Germany

    Giovanni Favero M.D., Ph.D. & Christhardt Köhler M.D., Ph.D.

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  1. Giovanni Favero M.D., Ph.D.
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  2. Christhardt Köhler M.D., Ph.D.
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  3. Alexandre Silva e Silva M.D.
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  4. Jesus Paula Carvalho M.D., Ph.D.
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  1. CliniOnco, Porto Alegre, Rio Grande do Sul, Brazil

    Geraldo Gastal Gomes-da-Silveira

  2. UFCSPA, Porto Alegre, Rio Grande do Sul, Brazil

    Gustavo Py Gomes da Silveira

  3. Universidade Federal do Rio Grande do Sul (UFRGS) and Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil

    Suzana Arenhart Pessini

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Favero, G., Köhler, C., Silva e Silva, A., Carvalho, J.P. (2018). Ovarian Cancer: Current Applications of Minimally Invasive Techniques. In: Gomes-da-Silveira, G.G., da Silveira, G.P.G., Pessini, S.A. (eds) Minimally Invasive Gynecology. Springer, Cham. https://doi.org/10.1007/978-3-319-72592-5_30

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