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Anti-parasitic Antibodies from Phage Display

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Recombinant Antibodies for Infectious Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1053))

Abstract

Parasite infections affect billions of people and their domesticated animals worldwide, and remain as a significant cause of morbidity and mortality, but such diseases are still neglected in endemic countries. Therapeutic interventions consisted mostly of drugs, which are highly toxic and may lead to resistance. The immunopathology of parasites is very complex due to their multistage life cycles and long lifetime involving several hosts, leading many times to chronic infections and sometimes to death, by compromising nutritional status, affecting cognitive processes, and inducing severe tissue reactions. Vaccination is a challenge, and immunotherapy is completely disregarded because of their complex interactions with hosts and vectors. This review will bring concepts of immunological aspects for some important parasitic infections, and present the most recent phage display-derived antibodies or peptidomimetics for parasite targets. This chapter will also discuss the future perspectives of such potential anti-infective immunobiologicals for parasitic diseases.

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Authors and Affiliations

  1. Laboratory of Nanobiotechnology, Institute of Genetics and Biochemistry, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil

    Luiz R. Goulart

  2. Department of Medical Microbiology and Immunology, University of California-Davis, Genome and Biomedical Sciences Facility, Davis, CA, USA

    Luiz R. Goulart

  3. Federal University of Goias, Catalão, Goias, Brazil

    Vanessa da S. Ribeiro

  4. Laboratory of Parasitology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil

    Julia M. Costa-Cruz

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  1. Luiz R. Goulart
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  2. Vanessa da S. Ribeiro
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  3. Julia M. Costa-Cruz
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Correspondence to Luiz R. Goulart .

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  1. Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang, Malaysia

    Theam Soon Lim

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Goulart, L.R., da S. Ribeiro, V., Costa-Cruz, J.M. (2017). Anti-parasitic Antibodies from Phage Display. In: Lim, T. (eds) Recombinant Antibodies for Infectious Diseases. Advances in Experimental Medicine and Biology, vol 1053. Springer, Cham. https://doi.org/10.1007/978-3-319-72077-7_8

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