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Endocrine Causes of Implantation Failure

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Book cover Recurrent Implantation Failure

Abstract

Achieving successful implantation requires a complex endocrine stimulus of the endometrium. A deep understanding of this highly coordinated process is required for clinicians and investigators attempting to optimize an individual patient’s likelihood of success. Our current level of knowledge is the result of many elegant studies to elucidate these mechanisms. However, our tools for assessing the proper functioning of the endometrium in relation to hormonal response are limited. Modern infertility therapies that rely on gonadotropin stimulation undoubtedly change the chronology and histology of endometrium response. However, many patients achieve success despite these alterations. Patients with recurrent implantation failure, however, may be more sensitive to forces which change the normal physiologic state. Thus, careful attention to these issues in these patients is paramount. This chapter attempts to lay the groundwork for a comprehensive understanding of normal endometrial response, assess current diagnostic options and their limitations, and describe how pathological processes can disrupt normal implantation.

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Authors and Affiliations

  1. Sidney Kimmel Medical College, Thomas Jefferson University Philadelphia, Philadelphia, PA, USA

    Scott Morin MD

  2. IVI-RMA of New Jersey, Basking Ridge, NJ, USA

    Scott Morin MD

  3. Department of Obstetrics and Gynecology, Koc University School of Medicine, Istanbul, Turkey

    Baris Ata MD

  4. Department of Obstetrics Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA

    Emre Seli MD

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  1. Scott Morin MD
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Correspondence to Emre Seli MD .

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Editors and Affiliations

  1. Reproductive Medicine Associates of NJ, Thomas Jefferson University, Basking Ridge, New Jersey, USA

    Jason M. Franasiak

  2. Reproductive Medicine Associates of NJ, Thomas Jefferson University, Basking Ridge, New Jersey, USA

    Richard T. Scott Jr.

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Morin, S., Ata, B., Seli, E. (2018). Endocrine Causes of Implantation Failure. In: Franasiak, J., Scott Jr., R. (eds) Recurrent Implantation Failure. Springer, Cham. https://doi.org/10.1007/978-3-319-71967-2_9

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  • DOI: https://doi.org/10.1007/978-3-319-71967-2_9

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