Skip to main content

Lymphatic Interventions

  • Chapter
  • First Online:
IR Playbook

Abstract

Thoracic duct embolization (TDE) is performed to treat accumulation of lymphatic or chylous fluid in the pleural or pericardial space originating from a traumatic or non-traumatic etiology. Traumatic, often postsurgical, chylothorax can be treated by use of intranodal lymphangiography and TDE with platinum-based coils and n-butyl cyanoacrylate (n-BCA) glue with both a high degree of clinical success and low incidence of complications. As the etiology and site of leaks from non-traumatic chylothorax can vary and be difficult to identify on fluoroscopy, advanced lymphatic imaging using MR lymphangiography can guide the treatment plan as the thoracic duct or its branches may not be the sole source of the chylous leak in these instances. Lastly, early data in both children and adults has demonstrated the effectiveness of TDE to treat plastic bronchitis, a condition in which the pulmonary lymphatics have retrograde flow into the lung parenchyma resulting in the development of chyle casts in the airway. In the subsequent chapter, we will review the pathophysiology of chylothorax and plastic bronchitis as well as the imaging and treatment methods for these conditions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. McGrath EE, Blades Z, Anderson PB. Chylothorax: aetiology, diagnosis and therapeutic options. Respir Med. 2010;104(1):1–8.

    Article  PubMed  Google Scholar 

  2. Nadolski GJ, Itkin M. Thoracic duct embolization (TDE) for nontraumatic chylous effusion: experience in 34 patients. Chest. 2013;143(1):158–63.

    Article  PubMed  Google Scholar 

  3. Valentine VG, Raffin TA. The management of chylothorax. Chest. 1992;102(2):586–91.

    Article  PubMed  CAS  Google Scholar 

  4. Itkin M. Interventional treatment of pulmonary lymphatic anomalies. Tech Vasc Interv Radiol. 2016;19(4):299–304.

    Article  PubMed  Google Scholar 

  5. Dori Y, Dori Y, Keller MS, Keller MS, Rychik J, Rychik J, Itkin M, Itkin M. Successful treatment of plastic bronchitis by selective lymphatic embolization in a Fontan patient. Pediatrics. 2014;134(2):e590–5.

    Article  PubMed  Google Scholar 

  6. Itkin MG, McCormack FX, Dori Y. Diagnosis and treatment of lymphatic plastic bronchitis in adults using advanced lymphatic imaging and percutaneous embolization. Ann AmThorac Soc. 2016;13(10):1689–96.

    Google Scholar 

  7. Seriff NS, Cohen ML, Samuel P, Schulster PL. Chylothorax: diagnosis by lipoprotein electrophoresis of serum and pleural fluid. Thorax. 1977;32(1):98–100.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Nadolski G, Itkin M. Thoracic duct embolization for the management of chylothoraces. Curr Opin Pulm Med. 2013;19(4):1–386.

    Google Scholar 

  9. Stecker MS, Fan C-M. Lymphangiography for thoracic duct interventions. Tech Vasc Interv Radiol. 2016;19(4):277–85.

    Article  PubMed  Google Scholar 

  10. Cerfolio RJ, Allen MS, Deschamps C, Trastek VF, Pairolero PC. Postoperative chylothorax. J Thorac Cardiovasc Surg. 1996;112(5):1361–5. discussion 1365–6.

    Article  PubMed  CAS  Google Scholar 

  11. Bender B, Murthy V, Chamberlain RS. The changing management of chylothorax in the modern era. Eur J Cardiothorac Surg. 2016;49(1):18–24.

    Article  PubMed  Google Scholar 

  12. Kerlan RK, LaBerge JM. Intranodal lymphangiography: coming soon to a hospital near you. J Vasc Interv Radiol. 2012;23(5):617.

    Article  PubMed  Google Scholar 

  13. Cope C, Salem R, Kaiser LR. Management of chylothorax by percutaneous catheterization and embolization of the thoracic duct: prospective trial. J Vasc Interv Radiol. 1999;10(9):1248–54.

    Article  PubMed  CAS  Google Scholar 

  14. Nadolski GJ, Itkin M. Feasibility of ultrasound-guided intranodal lymphangiogram for thoracic duct embolization. J Vasc Interv Radiol. 2012;23(5):613–6.

    Article  PubMed  Google Scholar 

  15. Dori Y, Zviman MM, Itkin M, Dynamic Contrast-enhanced MR. Lymphangiography: feasibility study in swine. Radiology. 2014;273(2):410–6.

    Article  PubMed  Google Scholar 

  16. Krishnamurthy R, Hernandez A, Kavuk S, Annam A, Pimpalwar S. Imaging the central conducting lymphatics: initial experience with dynamic MR lymphangiography. Radiology. 2015;274(3):871–8.

    Article  PubMed  Google Scholar 

  17. Chen E, Itkin M. Thoracic duct embolization for chylous leaks. Semin Interv Radiol. 2011;28(1):63–74.

    Article  CAS  Google Scholar 

  18. Cope C, Kaiser LR. Management of unremitting chylothorax by percutaneous embolization and blockage of retroperitoneal lymphatic vessels in 42 patients. J Vasc Interv Radiol. 2002;13(11):1139–48.

    Article  PubMed  Google Scholar 

  19. Itkin M, Kucharczuk JC, Kwak A, Trerotola SO, Kaiser LR. Nonoperative thoracic duct embolization for traumatic thoracic duct leak: experience in 109 patients. J Thorac Cardiovasc Surg. 2010;139(3):584–90.

    Article  PubMed  Google Scholar 

  20. Hur S, Shin JH, Lee IJ, et al. Early experience in the management of postoperative lymphatic leakage using lipiodol lymphangiography and adjunctive glue embolization. J Vasc Interv Radiol. 2016;27:1177–86.

    Article  PubMed  Google Scholar 

  21. Kozlov A, Itkin M, Dori Y, Nadolski G. Comparison of pedal and intranodal lymphangiography for thoracic duct embolization (TDE) of traumatic chylous leaks. J Vasc Interv Radiol. 2017;28(Suppl):S135.

    Article  Google Scholar 

  22. Maldonado F, Cartin-Ceba R, Hawkins FJ, Ryu JH. Medical and surgical management of chylothorax and associated outcomes. Am J Med Sci. 2010;339(4):314–8.

    Article  PubMed  Google Scholar 

  23. Nadolski G. Nontraumatic Chylothorax: Diagnostic algorithm and treatment options. Tech Vasc Interv Radiol. 2016;19(4):286–90.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Maxim Itkin .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Nadolski, G.J., Itkin, M. (2018). Lymphatic Interventions. In: Keefe, N., Haskal, Z., Park, A., Angle, J. (eds) IR Playbook. Springer, Cham. https://doi.org/10.1007/978-3-319-71300-7_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-71300-7_23

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-71299-4

  • Online ISBN: 978-3-319-71300-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics