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Gynecologic Cancer

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Abstract

Gynecologic tumors constitute an important part of cancer in women. There have been improvements in outcomes after surgery, chemotherapy, and radiation therapy; however, patients do experience significant treatment-related side effects.

Besides the classical cytotoxic agents and hormonal agents, used for many years, the development of newer molecular targeted and immunotherapeutic agents is currently an exciting area of interest in the care of patients with gynecologic malignancies.

Challenges are careful selection of patients for optimizing the combination of treatment modalities and drugs in order to obtain optimal efficacy. The latter depends on several factors: (1) the drug must be active as single agent against the particular tumor; (2) the drugs should have different mechanisms of action to minimize emergence of drug resistance; (3) the drugs should have a biochemical basis of at least additive and preferably synergistic effects; (4) the drugs chosen should have a different spectrum of toxicity so they can be used for maximum cell kill at full doses; and (5) the drugs chosen should be administered intermittently so that cell kill is enhanced and prolonged immunosuppression is minimized. This chapter gives an overview of the currently used treatment modalities in gynecologic cancer, their side effects, and their management.

This is an updated version of the chapter contributed by Sevilay Altintas, Dirk L.A.L. Schrijvers, and Jan B. Vermorken for the book “Side Effects of Medical Cancer Therapy” in 2013. The updates in this chapter were solely done by Sevilay Altintas and Dirk L.A.L. Schrijvers.

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Authors and Affiliations

  1. Department of Medical Oncology, University Hospital Antwerp, Antwerp, Belgium

    Sevilay Altintas

  2. Department of Medical Oncology, Ziekenhuisnetwerk Antwerpen (ZNA), Antwerp, Belgium

    Dirk L. A. L. Schrijvers

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  1. Sevilay Altintas
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    Mario A. Dicato

  2. Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium

    Eric Van Cutsem

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Altintas, S., Schrijvers, D.L.A.L. (2018). Gynecologic Cancer. In: Dicato, M., Van Cutsem, E. (eds) Side Effects of Medical Cancer Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-70253-7_5

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