Skip to main content

Laser and Radiofrequency Ablation Procedures

  • Chapter
  • First Online:
  • 1576 Accesses

Abstract

The term interventional thyroidology refers to minimally invasive ultrasound-guided techniques to treat diseases of the endocrine neck, i.e., diseases of thyroid and parathyroid glands. Laser ablation (LA) and radiofrequency ablation (RFA) are two of these procedures used to destroy thyroid nodules and tumors using hyperthermia without surgical removal. Indications of LA and RFA technique for the treatment of endocrine neck diseases include symptomatic benign cold thyroid nodules, symptomatic thyroid cysts, autonomously functioning thyroid nodules, and recurrent thyroid cancer. Both thermal techniques have also been used for the treatment of parathyroid adenomas, but with several drawbacks and are no longer recommended. The advantages of in situ tumor ablation are reduced costs, the possibility of performing procedures on outpatients, the possibility of treating patients who are poor candidates for surgery due to age or comorbidity, and the possibility of treating patients who refuse surgery. LA and RFA are performed by endocrinologists, interventional radiologists, and surgeons.

This is a preview of subscription content, log in via an institution.

References

  1. Bown SG. Phototherapy in tumors. World J Surg. 1983;7(6):700–9.

    Article  CAS  PubMed  Google Scholar 

  2. Nolsøe CP, Torp-Pedersen S, Burcharth F, Horn T, Pedersen S, Christensen NE, et al. Interstitial hyperthermia of colorectal liver metastases with a US-guided Nd-YAG laser with a diffuser tip: a pilot clinical study. Radiology. 1993;187(2):333–7.

    Article  PubMed  Google Scholar 

  3. Amin Z, Harries SA, Lees WR, Bown SG. Interstitial tumour photocoagulation. Endosc Surg Allied Technol. 1993;1(4):224–9.

    CAS  PubMed  Google Scholar 

  4. Germer CT, Roggan A, Ritz JP, Isbert C, Albrecht D, Müller G, et al. Optical properties of native and coagulated human liver tissue and liver metastases in the near infrared range. Lasers Surg Med. 1998;23(4):194–203.

    Article  CAS  PubMed  Google Scholar 

  5. Heisterkamp J, van Hillegersberg R, Ijzermans JN. Interstitial laser coagulation for hepatic tumours. Br J Surg. 1999;86(3):293–304.

    Article  CAS  PubMed  Google Scholar 

  6. Nikfarjam M, Muralidharan V, Malcontenti-Wilson C, Christophi C. Progressive microvascular injury in liver and colorectal liver metastases following laser induced focal hyperthermia therapy. Lasers Surg Med. 2005;37(1):64–73.

    Article  PubMed  Google Scholar 

  7. Ritz JP, Lehmann KS, Zurbuchen U, Knappe V, Schumann T, Buhr HJ, et al. Ex vivo and in vivo evaluation of laser-induced thermotherapy for nodular thyroid disease. Lasers Surg Med. 2009;41(7):479–86.

    Article  PubMed  Google Scholar 

  8. Piana S, Riganti F, Froio E, Andrioli M, Pacella CM, Valcavi R. Pathological findings of thyroid nodules after percutaneous laser ablation: a series of 22 cases with cyto-histological correlation. Endocr Pathol. 2012;23(2):94–100.

    Article  PubMed  Google Scholar 

  9. Ritz JP, Roggan A, Isbert C, Müller G, Buhr HJ, Germer CT. Optical properties of native and coagulated porcine liver tissue between 400 and 2400 nm. Lasers Surg Med. 2001;29(3):205–12.

    Article  CAS  PubMed  Google Scholar 

  10. Hegedus L. Therapy: a new nonsurgical therapy option for benign thyroid nodules? Nat Rev Endocrinol. 2009;5(9):476–8.

    Article  PubMed  Google Scholar 

  11. Baek JH, Lee JH, Valcavi R, Pacella CM, Rhim H, Na DG. Thermal ablation for benign thyroid nodules: radiofrequency and laser. Korean J Radiol. 2011;12(5):525–40.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Gharib H, Hegedüs L, Pacella CM, Baek JH, Papini E. Clinical review: nonsurgical, image-guided, minimally invasive therapy for thyroid nodules. J Clin Endocrinol Metab. 2013;98(10):3949–57.

    Article  CAS  PubMed  Google Scholar 

  13. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1–133.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Gharib H, Papini E, Paschke R, Duick DS, Valcavi R, Hegedüs L, AACE/AME/ETA Task Force on Thyroid Nodules, et al. American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. Endocr Pract. 2010;16(Suppl 1):1–43.

    Article  PubMed  Google Scholar 

  15. Gharib H, Papini E, Garber JR, Duick DS, Harrell RM, Hegedüs L. American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules – 2016 update. Endocr Pract. 2016;22(5):622–39.

    PubMed  Google Scholar 

  16. Pacella CM, Bizzarri G, Guglielmi R, Anelli V, Bianchini A, Crescenzi A, et al. Thyroid tissue: US-guided percutaneous interstitial laser ablation-a feasibility study. Radiology. 2000;217(3):673–7.

    Article  CAS  PubMed  Google Scholar 

  17. Døssing H, Bennedbaek FN, Karstrup S, Hegedüs L. Benign solitary solid cold thyroid nodules: US-guided interstitial laser photocoagulation—initial experience. Radiology. 2002;225(1):53–7.

    Article  PubMed  Google Scholar 

  18. Pacella CM, Bizzarri G, Spiezia S, Bianchini A, Guglielmi R, Crescenzi A, et al. Thyroid tissue: US-guided percutaneous laser thermal ablation. Radiology. 2004;232(1):272–80.

    Article  PubMed  Google Scholar 

  19. Papini E, Guglielmi R, Bizzarri G, Pacella CM. Ultrasound-guided laser thermal ablation for treatment of benign thyroid nodules. Endocr Pract. 2004;10(3):276–83.

    Article  PubMed  Google Scholar 

  20. Cakir B, Topaloglu O, Gul K, Agac T, Aydin C, Dirikoc A, et al. Effects of percutaneous laser ablation treatment in benign solitary thyroid nodules on nodule volume, thyroglobulin and anti-thyroglobulin levels, and cytopathology of nodule in 1 yr follow-up. J Endocrinol Investig. 2006;29(10):876–84.

    Article  CAS  Google Scholar 

  21. Amabile G, Rotondi M, De Chiara G, Silvestri A, Di Filippo B, Bellastella A, et al. Low-energy interstitial laser photocoagulation for treatment of nonfunctioning thyroid nodules: therapeutic outcome in relation to pretreatment and treatment parameters. Thyroid. 2006;16(8):749–55.

    Article  PubMed  Google Scholar 

  22. Døssing H, Bennedbaek FN, Hegedüs L. Effect of ultrasound-guided interstitial laser photocoagulation on benign solitary solid cold thyroid nodules: one versus three treatments. Thyroid. 2006;16(8):763–8.

    Article  PubMed  Google Scholar 

  23. Valcavi R, Riganti F, Bertani A, Formisano D, Pacella CM. Percutaneous laser ablation of cold benign thyroid nodules. A three-year follow-up in 122 patients. Thyroid. 2010;20(11):1253–61.

    Article  CAS  PubMed  Google Scholar 

  24. Døssing H, Bennedbæk FN, Hegedüs L. Long-term outcome following interstitial laser photocoagulation of benign cold thyroid nodules. Eur J Endocrinol. 2011;165(1):123–8.

    Article  CAS  PubMed  Google Scholar 

  25. Amabile G, Rotondi M, Pirali B, Dionisio R, Agozzino L, Lanza M, et al. Interstitial laser photocoagulation for benign thyroid nodules: time to treat large nodules. Lasers Surg Med. 2011;43(8):797–803.

    Article  PubMed  Google Scholar 

  26. Gambelunghe G, Fede R, Bini V, Monacelli M, Avenia N, D’Ajello M, et al. Ultrasound-guided interstitial laser ablation for thyroid nodules is effective only at high total amounts of energy: results from a three-year pilot study. Surg Innov. 2013;20(4):345–50.

    Article  PubMed  Google Scholar 

  27. Achille G, Zizzi S, Di Stasio E, Grammatica A, Grammatica L. Ultrasound-guided percutaneous laser ablation in treating symptomatic solid benign thyroid nodules: our experience in 45 patients. Head Neck. 2016;38(5):677–82.

    Article  PubMed  Google Scholar 

  28. Pacella CM, Mauri G, Achille G, Barbaro D, Bizzarri G, De Feo P, et al. Outcomes and risk factors for complications of laser ablation for thyroid nodules: a Multicenter study on 1531 patients. J Clin Endocrinol Metab. 2015;100(10):3903–10.

    Article  CAS  PubMed  Google Scholar 

  29. Negro R, Salem TM, Greco G. Laser ablation is more effective for spongiform than solid thyroid nodules. A 4-year retrospective follow-up study. Int J Hyperth. 2016;32(7):822–8.

    Article  Google Scholar 

  30. Døssing H, Bennedbaek FN, Hegedüs L. Beneficial effect of combined aspiration and interstitial laser therapy in patients with benign cystic thyroid nodules: a pilot study. Br J Radiol. 2006;79(948):943–7.

    Article  PubMed  Google Scholar 

  31. Døssing H, Bennedbæk FN, Hegedüs L. Interstitial laser photocoagulation (ILP) of benign cystic thyroid nodules—a prospective randomized trial. J Clin Endocrinol Metab. 2013;98(7):E1213–7.

    Article  CAS  PubMed  Google Scholar 

  32. Døssing H, Bennedbaek FN, Hegedüs L. Ultrasound-guided interstitial laser photocoagulation of an autonomous thyroid nodule: the introduction of a novel alternative. Thyroid. 2003;13(9):885–8.

    Article  PubMed  Google Scholar 

  33. Spiezia S, Vitale G, Di Somma C, Pio Assanti A, Ciccarelli A, Lombardi G, et al. Ultrasound-guided laser thermal ablation in the treatment of autonomous hyperfunctioning thyroid nodules and compressive nontoxic nodular goiter. Thyroid. 2003;13(10):941–7.

    Article  PubMed  Google Scholar 

  34. Barbaro D, Orsini P, Lapi P, Pasquini C, Tuco A, Righini A, et al. Percutaneous laser ablation in the treatment of toxic and pretoxic nodular goiter. Endocr Pract. 2007;13(1):30–6.

    Article  PubMed  Google Scholar 

  35. Cakir B, Gul K, Ugras S, Ersoy R, Topaloglu O, Agac T, et al. Percutaneous laser ablation of an autonomous thyroid nodule: effects on nodule size and histopathology of the nodule 2 years after the procedure. Thyroid. 2008;18(7):803–5.

    Article  PubMed  Google Scholar 

  36. Rotondi M, Amabile G, Leporati P, Di Filippo B, Chiovato L. Repeated laser thermal ablation of a large functioning thyroid nodule restores euthyroidism and ameliorates constrictive symptoms. J Clin Endocrinol Metab. 2009;94(2):382–3.

    Article  CAS  PubMed  Google Scholar 

  37. Chianelli M, Bizzarri G, Todino V, Misischi I, Bianchini A, Graziano F, et al. Laser ablation and 131-iodine: a 24-month pilot study of combined treatment for large toxic nodular goiter. J Clin Endocrinol Metab. 2014;99(7):E1283–6.

    Article  CAS  PubMed  Google Scholar 

  38. Negro R, Greco G. Large multinodular toxic goiter: is surgery always necessary? Case Rep Endocrinol. 2016;2016:1320827.

    PubMed  PubMed Central  Google Scholar 

  39. Døssing H, Bennedbaek FN, Hegedüs L. Effect of ultrasound-guided interstitial laser photocoagulation on benign solitary solid cold thyroid nodules – a randomised study. Eur J Endocrinol. 2005;152(3):341–5.

    Article  CAS  PubMed  Google Scholar 

  40. Papini E, Guglielmi R, Bizzarri G, Graziano F, Bianchini A, Brufani C, et al. Treatment of benign cold thyroid nodules: a randomized clinical trial of percutaneous laser ablation versus levothyroxine therapy or follow-up. Thyroid. 2007;17(3):229–35.

    Article  CAS  PubMed  Google Scholar 

  41. Døssing H, Bennedbaek FN, Bonnema SJ, Grupe P, Hegedüs L. Randomized prospective study comparing a single radioiodine dose and a single laser therapy session in autonomously functioning thyroid nodules. Eur J Endocrinol. 2007;157(1):95–100.

    Article  CAS  PubMed  Google Scholar 

  42. Gambelunghe G, Fatone C, Ranchelli A, Fanelli C, Lucidi P, Cavaliere A, et al. A randomized controlled trial to evaluate the efficacy of ultrasound-guided laser photocoagulation for treatment of benign thyroid nodules. J Endocrinol Investig. 2006;29(9):RC23–6.

    Article  CAS  Google Scholar 

  43. Papini E, Rago T, Gambelunghe G, Valcavi R, Bizzarri G, Vitti P, et al. Long-term efficacy of ultrasound-guided laser ablation for benign solid thyroid nodules. Results of a three-year multicenter prospective randomized trial. J Clin Endocrinol Metab. 2014;99(10):3653–9.

    Article  CAS  PubMed  Google Scholar 

  44. Cakir B, Gul K, Ersoy R, Topaloglu O, Korukluoglu B. Subcapsular hematoma complication during percutaneous laser ablation to a hypoactive benign solitary thyroid nodule. Thyroid. 2008;18(8):917–8.

    Article  PubMed  Google Scholar 

  45. Di Rienzo G, Surrente C, Lopez C, Quercia R. Tracheal laceration after laser ablation of nodular goitre. Interact Cardiovasc Thorac Surg. 2012;14(1):115–6.

    Article  PubMed  Google Scholar 

  46. Valcavi R, Stecconi Bortolani G, Riganti F, Pacella C. Thyroid spongiform nodules are the best candidates for percutaneous laser ablation. A 5 year follow-up study in 72 patients. Presented at 15th International & 14th European Congress of Endocrinology, 2012, Florence, Italy. Endocrine Abstracts 29 OC2.5.

    Google Scholar 

  47. Valcavi R, Frasoldati A. Ultrasound-guided percutaneous ethanol injection therapy in thyroid cystic nodules. Endocr Pract. 2004;10(3):269–75.

    Article  PubMed  Google Scholar 

  48. Durante C, Montesano T, Torlontano M, Attard M, Monzani F, Tumino S, et al. Papillary thyroid cancer: time course of recurrences during post surgery surveillance. Clin Endocrinol Metab. 2013;98(2):636–42.

    Article  CAS  Google Scholar 

  49. Samaan NA, Schultz PN, Hickey RC, Goepfert H, Haynie TP, Johnston DA, et al. The results of various modalities of treatment of well differentiated thyroid carcinomas: a retrospective review of 1599 patients. J Clin Endocrinol Metab. 1992;75(3):714–20.

    CAS  PubMed  Google Scholar 

  50. Papini E, Bizzarri G, Bianchini A, Valle D, Misischi I, Guglielmi R, et al. Percutaneous ultrasound-guided laser ablation is effective for treating selected nodal metastases in papillary thyroid cancer. J Clin Endocrinol Metab. 2013;98(1):E92–7.

    Article  CAS  PubMed  Google Scholar 

  51. Mauri G, Cova L, Tondolo T, Ierace T, Baroli A, Di Mauro E, et al. Percutaneous laser ablation of metastatic lymph nodes in the neck from papillary thyroid carcinoma: preliminary results. J Clin Endocrinol Metab. 2013;98(7):E1203–7.

    Article  CAS  PubMed  Google Scholar 

  52. Zhou W, Zhang L, Zhan W, Jiang S, Zhu Y, Xu S. Percutaneous laser ablation for treatment of locally recurrent papillary thyroid carcinoma <15 mm. Clin Radiol. 2016;71(12):1233–9. https://doi.org/10.1016/j.crad.2016.07.010.

    Article  CAS  PubMed  Google Scholar 

  53. Mauri G, Cova L, Ierace T, Baroli A, Di Mauro E, Pacella CM, et al. Treatment of metastatic lymph nodes in the neck from papillary thyroid carcinoma with percutaneous laser ablation. Cardiovasc Intervent Radiol. 2016;39(7):1023–30. https://doi.org/10.1007/s00270-016-1313-6.

    Article  PubMed  Google Scholar 

  54. Valcavi R, Piana S, Bortolan GS, Lai R, Barbieri V, Negro R. Ultrasound-guided percutaneous laser ablation of papillary thyroid microcarcinoma: a feasibility study on three cases with pathological and immunohistochemical evaluation. Thyroid. 2013;23(12):1578–82.

    Article  PubMed  Google Scholar 

  55. Baloch ZW, LiVolsi VA, Asa SL, Rosai J, Merino MJ, Randolph G, et al. Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute thyroid fine-needle aspiration state of the science conference. Diagn Cytopathol. 2008;36(6):425–37.

    Article  PubMed  Google Scholar 

  56. Andrioli M, Riganti F, Pacella CM, Valcavi R. Long-term effectiveness of ultrasound-guided laser ablation of hyperfunctioning parathyroid adenomas: present and future perspectives. AJR Am J Roentgenol. 2012;199(5):1164–8.

    Article  PubMed  Google Scholar 

  57. Ha EJ, Baek JH, Lee JH. The efficacy and complications of radiofrequency ablation of thyroid nodules. Curr Opin Endocrinol Diabetes Obes. 2011;18(5):310–4.

    Article  PubMed  Google Scholar 

  58. Na DG, Lee JH, Jung SL, Kim JH, Sung JY, Shin JH, Korean Society of Thyroid Radiology (KSThR); Korean Society of Radiology, et al. Radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers: consensus statement and recommendations. Korean J Radiol. 2012;13(2):117–25.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Garberoglio R, Aliberti C, Appetecchia M, Attard M, Boccuzzi G, Boraso F, et al. Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement. J Ultrasound. 2015;18(4):423–30.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Korkusuz Y, Erbelding C, Kohlhase K, Luboldt W, Happel C, Grünwald F. Bipolar radiofrequency ablation of benign symptomatic thyroid nodules: initial experience. Rofo. 2016;188(7):671–5.

    CAS  PubMed  Google Scholar 

  61. Li XL, Xu HX, Lu F, Yue WW, Sun LP, Bo XW, et al. Treatment efficacy and safety of ultrasound-guided percutaneous bipolar radiofrequency ablation for benign thyroid nodules. Br J Radiol. 2016;89(1059):2015085. https://doi.org/10.1259/bjr.20150858.

    Article  Google Scholar 

  62. Kohlhase KD, Korkusuz Y, Gröner D, Erbelding C, Happel C, Luboldt W, et al. Bipolar radiofrequency ablation of benign thyroid nodules using a multiple overlapping shot technique in a 3-month follow-up. Int J Hyperth. 2016;32(5):511–6. https://doi.org/10.3109/02656736.2016.1149234.

    Article  Google Scholar 

  63. Spiezia S, Garberoglio R, Di Somma C, Deandrea M, Basso E, Limone PP, et al. Efficacy and safety of radiofrequency thermal ablation in the treatment of thyroid nodules with pressure symptoms in elderly patients. J Am Geriatr Soc. 2007;55(9):1478–9.

    Article  PubMed  Google Scholar 

  64. Deandrea M, Limone P, Basso E, Mormile A, Ragazzoni F, Gamarra E, et al. US-guided percutaneous radiofrequency thermal ablation for the treatment of solid benign hyperfunctioning or compressive thyroid nodules. Ultrasound Med Biol. 2008;34(5):784–91.

    Article  PubMed  Google Scholar 

  65. Spiezia S, Garberoglio R, Milone F, Ramundo V, Caiazzo C, Assanti AP, et al. Thyroid nodules and related symptoms are stably controlled two years after radiofrequency thermal ablation. Thyroid. 2009;19(3):219–25.

    Article  PubMed  Google Scholar 

  66. Baek JH, Moon WJ, Kim YS, Lee JH, Lee D. Radiofrequency ablation for the treatment of autonomously functioning thyroid nodules. World J Surg. 2009;33(9):1971–7.

    Article  PubMed  Google Scholar 

  67. Shin JH, Baek JH, Ha EJ, Lee JH. Radiofrequency ablation of thyroid nodules: basic principles and clinical application. Int J Endocrinol. 2012;2012:919650.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Valcavi R, Tsamatropoulos P. Health-related quality of life after percutaneous radiofrequency ablation of cold, solid, benign thyroid nodules: a 2-year follow-up study in 40 patients. Endocr Pract. 2015;21(8):887–96.

    Article  PubMed  Google Scholar 

  69. Deandrea M, Sung JY, Limone P, Mormile A, Garino F, Ragazzoni F, et al. Efficacy and safety of radiofrequency ablation versus observation for nonfunctioning benign thyroid nodules: a randomized controlled international collaborative trial. Thyroid. 2015;25(8):890–6.

    Article  PubMed  Google Scholar 

  70. Baek JH, Lee JH, Sung JY, Bae JI, Kim KT, Sim J, et al. Korean Society of Thyroid Radiology. Complications encountered in the treatment of benign thyroid nodules with US-guided radiofrequency ablation: a multicenter study. Radiology. 2012;262(1):335–42.

    Article  PubMed  Google Scholar 

  71. Ha EJ, Baek JH, Lee JH. Ultrasonography-based thyroidal and perithyroidal anatomy and its clinical significance. Korean J Radiol. 2015;16(4):749–66.

    Article  PubMed  PubMed Central  Google Scholar 

  72. Ha EJ, Baek JH, Lee JH, Kim JK, Shong YK. Clinical significance of vagus nerve variation in radiofrequency ablation of thyroid nodules. Eur Radiol. 2011;21(10):2151–7.

    Article  PubMed  Google Scholar 

  73. Shin JH, Jung SL, Baek JH, Kim JH. Rupture of benign thyroid tumors after radio-frequency ablation. AJNR Am J Neuroradiol. 2011;32(11):2165–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Chehade JM, Silverberg AB, Kim J, Case C, Mooradian AD. Role of repeated fine-needle aspiration of thyroid nodules with benign cytologic features. Endocr Pract. 2001;7(4):237–43.

    Article  CAS  PubMed  Google Scholar 

  75. Illouz F, Rodien P, Saint-André JP, Triau S, Laboureau-Soares S, Dubois S, et al. Usefulness of repeated fine-needle cytology in the follow-up of non-operated thyroid nodules. Eur J Endocrinol. 2007;156(3):303–8.

    Article  CAS  PubMed  Google Scholar 

  76. Kwak JY, Koo H, Youk JH, Kim MJ, Moon HJ, Son EJ, et al. Value of US correlation of a thyroid nodule with initially benign cytologic results. Radiology. 2010;254(1):292–300.

    Article  PubMed  Google Scholar 

  77. Piana S, Frasoldati A, Ferrari M, Valcavi R, Froio E, Barbieri V, et al. Is a five-category reporting scheme for thyroid fine needle aspiration cytology accurate? Experience of over 18,000 FNAs reported at the same institution during 1998–2007. Cytopathology. 2011;22(3):164–73.

    Article  CAS  PubMed  Google Scholar 

  78. Kim YS, Rhim H, Tae K, Park DW, Kim ST. Radiofrequency ablation of benign cold thyroid nodules: initial clinical experience. Thyroid. 2006;16(4):361–7.

    Article  PubMed  Google Scholar 

  79. Fuller CW, Nguyen SA, Lohia S, Gillespie MB. Radiofrequency ablation for treatment of benign thyroid nodules: systematic review. Laryngoscope. 2014;124(1):346–53.

    Article  PubMed  Google Scholar 

  80. Bandeira-Echtler E, Bergerhoff K, Richter B. Levothyroxine or minimally invasive therapies for benign thyroid nodules. Cochrane Database Syst Rev. 2014;6:CD004098.

    Google Scholar 

  81. Chen F, Tian G, Kong D, Zhong L, Jiang T. Radiofrequency ablation for treatment of benign thyroid nodules: a PRISMA-compliant systematic review and meta-analysis of outcomes. Medicine (Baltimore). 2016;95(34):e4659.

    Article  Google Scholar 

  82. Bernardi S, Dobrinja C, Fabris B, Bazzocchi G, Sabato N, Ulcigrai V, et al. Radiofrequency ablation compared to surgery for the treatment of benign thyroid nodules. Int J Endocrinol. 2014;2014:934595.

    Article  PubMed  PubMed Central  Google Scholar 

  83. Che Y, Jin S, Shi C, Wang L, Zhang X, Li Y, Baek JH. Treatment of benign thyroid nodules: comparison of surgery with radiofrequency ablation. AJNR Am J Neuroradiol. 2015;36(7):1321–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Baek JH, Kim YS, Lee D, Huh JY, Lee JH. Benign predominantly solid thyroid nodules: prospective study of efficacy of sonographically guided radiofrequency ablation versus control condition. AJR Am J Roentgenol. 2010;194(4):1137–42.

    Article  PubMed  Google Scholar 

  85. Faggiano A, Ramundo V, Assanti AP, Fonderico F, Macchia PE, Misso C, et al. Thyroid nodules treated with percutaneous radiofrequency thermal ablation: a comparative study. J Clin Endocrinol Metab. 2012;97(12):4439–45.

    Article  CAS  PubMed  Google Scholar 

  86. Wong KP, Lang BH. Use of radiofrequency ablation in benign thyroid nodules: a literature review and updates. Int J Endocrinol. 2013;2013:428363.

    Article  PubMed  PubMed Central  Google Scholar 

  87. Turtulici G, Orlandi D, Corazza A, Sartoris R, Derchi LE, Silvestri E, et al. Percutaneous radiofrequency ablation of benign thyroid nodules assisted by a virtual needle tracking system. Ultrasound Med Biol. 2014;40(7):1447–52.

    Article  PubMed  Google Scholar 

  88. Cesareo R, Pasqualini V, Simeoni C, Sacchi M, Saralli E, Campagna G, et al. Prospective study of effectiveness of ultrasound-guided radiofrequency ablation versus control group in patients affected by benign thyroid nodules. J Clin Endocrinol Metab. 2015;100(2):460–6.

    Article  CAS  PubMed  Google Scholar 

  89. Ugurlu MU, Uprak K, Akpinar IN, Attaallah W, Yegen C, Gulluoglu BM. Radiofrequency ablation of benign symptomatic thyroid nodules: prospective safety and efficacy study. World J Surg. 2015;39(4):961–8.

    Article  PubMed  Google Scholar 

  90. De Bernardi IC, Floridi C, Muollo A, Giacchero R, Dionigi GL, Reginelli A, et al. Vascular and interventional radiology radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers: literature review. Radiol Med. 2014;119(7):512–20.

    Article  PubMed  Google Scholar 

  91. Jeong WK, Baek JH, Rhim H, Kim YS, Kwak MS, Jeong HJ, et al. Radiofrequency ablation of benign thyroid nodules: safety and imaging follow-up in 236 patients. Eur Radiol. 2008;18(6):1244–50.

    Article  PubMed  Google Scholar 

  92. Huh JY, Baek JH, Choi H, Kim JK, Lee JH. Symptomatic benign thyroid nodules: efficacy of additional radiofrequency ablation treatment session-prospective randomized study. Radiology. 2012;263(3):909–16.

    Article  PubMed  Google Scholar 

  93. Lim HK, Lee JH, Ha EJ, Sung JY, Kim JK, Baek JH. Radiofrequency ablation of benign non-functioning thyroid nodules: 4-year follow-up results for 111 patients. Eur Radiol. 2013;23(4):1044–9.

    Article  PubMed  Google Scholar 

  94. Dobrinja C, Bernardi S, Fabris B, Eramo R, Makovac P, Bazzocchi G, et al. Surgical and pathological changes after radiofrequency ablation of thyroid nodules. Int J Endocrinol. 2015;2015:576576.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  95. Ha EJ, Baek JH, Lee JH, Sung JY, Lee D, Kim JK, et al. Radiofrequency ablation of benign thyroid nodules does not affect thyroid function in patients with previous lobectomy. Thyroid. 2013;23(3):289–93.

    Article  CAS  PubMed  Google Scholar 

  96. Ji Hong M, Baek JH, Choi YJ, Lee JH, Lim HK, Shong YK, et al. Radiofrequency ablation is a thyroid function-preserving treatment for patients with bilateral benign thyroid nodules. J Vasc Interv Radiol. 2015;26(1):55–61.

    Article  PubMed  Google Scholar 

  97. Andrioli M, Valcavi R. The peculiar ultrasonographic and elastographic features of thyroid nodules after treatment with laser or radiofrequency: similarities and differences. Endocrine. 2014;47(3):967–8.

    Article  CAS  PubMed  Google Scholar 

  98. Sung JY, Kim YS, Choi H, Lee JH, Baek JH. Optimum first-line treatment technique for benign cystic thyroid nodules: ethanol ablation or radiofrequency ablation? AJR Am J Roentgenol. 2011;196(2):W210–4.

    Article  PubMed  Google Scholar 

  99. Sung JY, Baek JH, Kim KS, Lee D, Yoo H, Kim JK, Park SH. Single-session treatment of benign cystic thyroid nodules with ethanol versus radiofrequency ablation: a prospective randomized study. Radiology. 2013;269(1):293–300.

    Article  PubMed  Google Scholar 

  100. Baek JH, Ha EJ, Choi YJ, Sung JY, Kim JK, Shong YK. Radiofrequency versus ethanol ablation for treating predominantly cystic thyroid nodules: a randomized clinical trial. Korean J Radiol. 2015;16(6):1332–40.

    Article  PubMed  PubMed Central  Google Scholar 

  101. Lee JH, Kim YS, Lee D, Choi H, Yoo H, Baek JH. Radiofrequency ablation (RFA) of benign thyroid nodules in patients with incompletely resolved clinical problems after ethanol ablation (EA). World J Surg. 2010;34(7):1488–93.

    Article  PubMed  Google Scholar 

  102. Jang SW, Baek JH, Kim JK, Sung JY, Choi H, Lim HK, et al. How to manage the patients with unsatisfactory results after ethanol ablation for thyroid nodules: role of radiofrequency ablation. Eur J Radiol. 2012;81(5):905–10.

    Article  PubMed  Google Scholar 

  103. Baek JH, Jeong HJ, Kim YS, Kwak MS, Lee D. Radiofrequency ablation for an autonomously functioning thyroid nodule. Thyroid. 2008;18(6):675–6.

    Article  PubMed  Google Scholar 

  104. Sung JY, Baek JH, Jung SL, Kim JH, Kim KS, Lee D, et al. Radiofrequency ablation for autonomously functioning thyroid nodules: a multicenter study. Thyroid. 2015;25(1):112–7.

    Article  CAS  PubMed  Google Scholar 

  105. Dupuy DE, Monchik JM, Decrea C, Pisharodi L. Radiofrequency ablation of regional recurrence from well-differentiated thyroid malignancy. Surgery. 2001;130(6):971–7.

    Article  CAS  PubMed  Google Scholar 

  106. Monchik JM, Donatini G, Iannuccilli J, Dupuy DE. Radiofrequency ablation and percutaneous ethanol injection treatment for recurrent local and distant well-differentiated thyroid carcinoma. Ann Surg. 2006;244(2):296–304.

    Article  PubMed  PubMed Central  Google Scholar 

  107. Baek JH, Kim YS, Sung JY, Choi H, Lee JH. Locoregional control of metastatic well-differentiated thyroid cancer by ultrasound-guided radiofrequency ablation. AJR Am J Roentgenol. 2011;197(2):W331–6.

    Article  PubMed  Google Scholar 

  108. Park KW, Shin JH, Han BK, Ko EY, Chung JH. Inoperable symptomatic recurrent thyroid cancers: preliminary result of radiofrequency ablation. Ann Surg Oncol. 2011;18(9):2564–8.

    Article  PubMed  Google Scholar 

  109. Shin JE, Baek JH, Lee JH. Radiofrequency and ethanol ablation for the treatment of recurrent thyroid cancers: current status and challenges. Curr Opin Oncol. 2013;25(1):14–9.

    Article  CAS  PubMed  Google Scholar 

  110. Lee SJ, Jung SL, Kim BS, Ahn KJ, Choi HS, Lim DJ, et al. Radiofrequency ablation to treat loco-regional recurrence of well-differentiated thyroid carcinoma. Korean J Radiol. 2014;15(6):817–26.

    Article  PubMed  PubMed Central  Google Scholar 

  111. Wang L, Ge M, Xu D, Chen L, Qian C, Shi K, et al. Ultrasonography-guided percutaneous radiofrequency ablation for cervical lymph node metastasis from thyroid carcinoma. J Cancer Res Ther. 2014;10(Suppl):C144–9.

    PubMed  Google Scholar 

  112. Lim HK, Baek JH, Lee JH, Kim WB, Kim TY, Shong YK, et al. Efficacy and safety of radiofrequency ablation for treating locoregional recurrence from papillary thyroid cancer. Eur Radiol. 2015;25(1):163–70.

    Article  PubMed  Google Scholar 

  113. Kim JH, Yoo WS, Park YJ, Park do J, Yun TJ, Choi SH, et al. Efficacy and safety of radiofrequency ablation for treatment of locally recurrent thyroid cancers smaller than 2 cm. Radiology. 2015;276(3):909–18.

    Article  PubMed  Google Scholar 

  114. Kim HS, Choi BH, Park JR, Hahm JR, Jung JH, Kim SK, et al. Delayed surgery for parathyroid adenoma misdiagnosed as a thyroid nodule and treated with radiofrequency ablation. Endocrinol Metab (Seoul). 2013;28(3):231–5.

    Article  Google Scholar 

  115. Xu SY, Wang Y, Xie Q, Wu HY. Percutaneous sonography guided radiofrequency ablation in the management of parathyroid adenoma. Singap Med J. 2013;54(7):e137–40.

    Article  Google Scholar 

  116. Kim BS, Eom TI, Kang KH, Park SJ. Radiofrequency ablation of parathyroid adenoma in primary hyperparathyroidism. J Med Ultrason (2001). 2014;41(2):239–43.

    Article  Google Scholar 

  117. Carrafiello G, Laganà D, Mangini M, Dionigi G, Rovera F, Carcano G, et al. Treatment of secondary hyperparathyroidism with ultrasonographically guided percutaneous radiofrequency thermoablation. Surg Laparosc Endosc Percutan Tech. 2006;16(2):112–6.

    Article  PubMed  Google Scholar 

  118. Lupo MA. Radiofrequency ablation for benign thyroid nodules – a look towards the future of interventional thyroidology. Endocr Pract. 2015;21(8):972–4.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Roberto Valcavi MD, FACE .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Cite this chapter

Tsamatropoulos, P., Valcavi, R. (2018). Laser and Radiofrequency Ablation Procedures. In: Duick, D., Levine, R., Lupo, M. (eds) Thyroid and Parathyroid Ultrasound and Ultrasound-Guided FNA . Springer, Cham. https://doi.org/10.1007/978-3-319-67238-0_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-67238-0_13

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-67237-3

  • Online ISBN: 978-3-319-67238-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics