Abstract
Craniopharyngioma tumors are histologically benign, but their management remains challenging because of their intimate relationship to vital neurovascular structures such as the optic apparatus, pituitary stalk, hypothalamus, and vessels of the circle of Willis. Surgery remains the mainstay of suprasellar craniopharyngioma management. Although total resection should be the goal, a subtotal resection with postoperative radiation is a reasonable option if the lesion is adherent to the hypothalamus or other eloquent midline structures. Open transcranial approaches are the standard of care for surgical intervention, which have stood the test of time. More recently, minimally invasive transcranial keyhole approaches and endoscopic endonasal approaches have been added to the armamentarium of skull base neurosurgeons. In 18.2, we discuss the options available for open transcranial approaches to craniopharyngioma tumors and consider their relative merits and limitations, patient selection criteria, perioperative care, complication avoidance, management principles, and surgical outcomes. No single operative technique can be considered as the “best approach” for all patients. Each patient is best served by the formulation of an individualized, tailored surgical plan that aims to realistically and safely achieve the expected management goals. The supraorbital “eyebrow” craniotomy is an ideal approach for those tumors that are anterior or superior to the optic apparatus, and we discuss this in 18.3. Meticulous attention to detail during the approach and tumor dissection as well as the closure will help achieve good tumor resection, minimize morbidity, and maintain cosmesis. The use of surgical tools such as the micro-Doppler probe and neuroendoscopy are helpful to visualize and preserve critical neurovascular structures. Attentive postoperative management is necessary for good long-term outcomes with close monitoring and treatment of endocrinopathies. The use of stereotactic radiation therapy and targeted molecular therapy should be utilized as necessary.
Recently, there has been increased application of the endoscopic endonasal approach for these tumors. In appropriately selected cases, the endoscopic endonasal approach offers excellent direct visualization of the undersurface of the optic chiasm and its vascular perforators, hypothalamus, and third ventricle, which contributes to safer microdissection and a more complete removal while minimizing potential complications. In 18.4, we review the technical nuances and surgical pearls for resection of suprasellar craniopharyngiomas using the endoscopic endonasal approach. We also discuss factors involved in approach selection and complication avoidance.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences (Key References Bolded)
Hoffman HJ. Surgical management of craniopharyngioma. Pediatr Neurosurg. 1994;21(Suppl 1):44–9.
Bunin GR, et al. The descriptive epidemiology of craniopharyngioma. Neurosurg Focus. 1997;3(6):e1.
Pan J, et al. Growth patterns of craniopharyngiomas: clinical analysis of 226 patients. J Neurosurg Pediatr. 2016;17(4):418–33.
Alli S, Isik S, Rutka JT. Microsurgical removal of craniopharyngioma: endoscopic and transcranial techniques for complication avoidance. J Neuro-Oncol. 2016 Nov;130(2):299–307.
Komotar RJ, Roguski M, Bruce JN. Surgical management of craniopharyngiomas. J Neurooncol. 2009 May;92(3):283–96.
Zada G, Laws ER. Surgical management of craniopharyngiomas in the pediatric population. Horm Res Paediatr. 2010;74(1):62–6.
Jung TY, Jung S, Choi JE, et al. Adult craniopharyngiomas: surgical results with a special focus on endocrinological outcomes and recurrence according to pituitary stalk preservation. J Neurosurg. 2009 Sep;111(3):572–7.
Elliott RE, Jane JA, Jr., Wisoff JH. Surgical management of craniopharyngiomas in children: meta-analysis and comparison of transcranial and transsphenoidal approaches. Neurosurgery. 2011 Sep;69(3):630–43. Discussion 43.
McLaughlin N, Ditzel Filho L, Shahlaie K, Solari D, Kassam A, Kelly D. The supraorbital approach for recurrent or residual suprasellar tumors. Minim Invasive Neurosurg. 2011;54(04):155–161.
Kassam A, Gardner P, Snyderman C, Carrau R, Mintz A, Prevedello D. Expanded endonasal approach, a fully endoscopic transnasal approach for the resection of midline suprasellar craniopharyngiomas: a new classification based on the infundibulum. J Neurosurg. 2008;108(4):715.
Barkhoudarian G, Cutler AR, Yost S, Lobo B, Eisenberg A, Kelly DF. Impact of selective pituitary gland incision or resection on hormonal function after adenoma or cyst resection. Pituitary. 2015;18(6):868–75.
Koutourousiou M, Gardner P, Fernandez-Miranda J, Tyler-Kabara E, Wang E, Snyderman C. Endoscopic endonasal surgery for craniopharyngiomas: surgical outcome in 64 patients. J Neurosurg. 2013;119(5):1194.
Dlouhy B, Madhavan K, Clinger J, et al. Elevated body mass index and risk of postoperative CSF leak following transsphenoidal surgery. J Neurosurg. 2012;116(6):1311.
Ivan M, Iorgulescu J, El-Sayed I, et al. Risk factors for postoperative cerebrospinal fluid leak and meningitis after expanded endoscopic endonasal surgery. J Clin Neurosci. 2015;22(1):48.
LeVay A, Kveton J. Relationship between obesity, obstructive sleep apnea, and spontaneous cerebrospinal fluid otorrhea. Laryngoscope. 2008;118(2):275.
Dare A, Landi M, Lopes D, Grand W. Eyebrow incision for combined orbital osteotomy and supraorbital minicraniotomy: application to aneurysms of the anterior circulation. J Neurosurg. 2001;95(4):714.
Figueiredo E, Deshmukh V, Nakaji P, et al. An anatomical evaluation of the mini-supraorbital approach and comparison with standard craniotomies. Neurosurgery. 2006;59(4 Suppl 2):ONS212.
Kobayashi T, Kida Y, Mori Y, Hasegawa T. Long-term results of gamma knife surgery for the treatment of craniopharyngioma in 98 consecutive cases. J Neurosurg. 2005;103(6):482–8.
Stripp D, Maity A, Janss A, et al. Surgery with or without radiation therapy in the management of craniopharyngiomas in children and young adults. Int J Radiat Oncol Biol Phys. 2004;58(3):714.
Komotar R, Starke R, Raper D, Anand V, Schwartz T. Endoscopic endonasal compared with microscopic transsphenoidal and open transcranial resection of craniopharyngiomas. World Neurosurg. 2012;77(2):329.
Sheehan J, Niranjan A, Sheehan J, et al. Stereotactic radiosurgery for pituitary adenomas: an intermediate review of its safety, efficacy, and role in the neurosurgical treatment armamentarium. J Neurosurg. 2005;102(4):678.
Gopalan R, Dassoulas K, Rainey J, Sherman J, Sheehan J. Evaluation of the role of Gamma Knife surgery in the treatment of craniopharyngiomas. Neurosurg Focus. 2008;24(5):E5.
Reisch R, Marcus H, Hugelshofer M, Koechlin N, Stadie A, Kockro R. Patients’ cosmetic satisfaction, pain, and functional outcomes after supraorbital craniotomy through an eyebrow incision. J Neurosurg. 2014;121(3):730.
Reisch R, Perneczky A. Ten-year experience with the supraorbital subfrontal approach through an eyebrow skin incision. Neurosurgery. 2005;57(4 Suppl):242.
Park J, Jung T, Kang D, Lee S. Preoperative percutaneous mapping of the frontal branch of the facial nerve to assess the risk of frontalis muscle palsy after a supraorbital keyhole approach. J Neurosurg. 2013;118(5):1114.
Dusick J, Esposito F, Malkasian D, Kelly D. Avoidance of carotid artery injuries in transsphenoidal surgery with the Doppler probe and micro-hook blades. Neurosurgery. 2007;60(4 Suppl 2):322.
Oskouian R, Kelly D, Laws E Jr. Vascular injury and transsphenoidal surgery. Front Horm Res. 2006;34:256.
Yaşargil M, Curcic M, Kis M, Siegenthaler G, Teddy P, Roth P. Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients. J Neurosurg. 1990;73(1):3.
Vinchon M, Weill J, Delestret I, Dhellemmes P. Craniopharyngioma and hypothalamic obesity in children. Child Nerv Syst. 2009;25(3):347.
Wilson D, Duong H, Teo C, Kelly D. The supraorbital endoscopic approach for tumors. World Neurosurg. 2014;82(6 Suppl):S72.
Ditzel FL, McLaughlin N, Bresson D, Solari D, Kassam A, Kelly D. Supraorbital eyebrow craniotomy for removal of intraaxial frontal brain tumors: a technical note. World Neurosurg. 2014;81(2):348.
Paladino J, Mrak G, Miklić P, Jednacak H, Mihaljević D. The keyhole concept in aneurysm surgery – a comparative study: keyhole versus standard craniotomy. Minim Invasive Neurosurg. 2005;48(5):251.
Cohen A, Perneczky A, Rodziewicz G, Gingold S. Endoscope-assisted craniotomy: approach to the rostral brain stem. Neurosurgery. 1995;36(6):1128.
Fatemi N, Dusick J, de Paiva NM, Malkasian D, Kelly D. Endonasal versus supraorbital keyhole removal of craniopharyngiomas and tuberculum sellae meningiomas. Neurosurgery. 2009;64(5 Suppl 2):269.
Liu JK, Sevak IA, Carmel PW, Eloy JA. Microscopic versus endoscopic approaches for craniopharyngiomas: choosing the optimal surgical corridor for maximizing extent of resection and complication avoidance using a personalized, tailored approach. Neurosurg Focus. 2016 Dec;41(6):E5.
Baldauf J, Hosemann W, Schroeder HW. Endoscopic endonasal approach for craniopharyngiomas. Neurosurg Clin N Am. 2015;26:363–75.
Liu JK, Christiano LD, Patel SK, Eloy JA. Surgical nuances for removal of retrochiasmatic craniopharyngioma via the endoscopic endonasal extended transsphenoidal transplanum transtuberculum approach. Neurosurg Focus. 2011 Apr;30(4):E14.
Oldfield EH. Transnasal endoscopic surgery for craniopharyngiomas. Neurosurg Focus. 2010 Apr;28(4):E8a. Discussion E8b.
Dhandapani S, et al. Endonasal endoscopic reoperation for residual or recurrent craniopharyngiomas. J Neurosurg. 2017;126:418–430.
Komotar RJ, Starke RM, Raper DM, Anand VK, Schwartz TH. Endoscopic endonasal compared with microscopic transsphenoidal and open transcranial resection of craniopharyngiomas. World Neurosurg. 2012;77:329–41.
Liu JK, Schmidt RF, Choudhry OJ, Shukla PA, Eloy JA. Surgical nuances for nasoseptal flap reconstruction of cranial base defects with high-flow cerebrospinal fluid leaks after endoscopic skull base surgery. Neurosurg Focus. 2012;32:E7.
Zacharia BE, Amine M, Anand V, Schwartz TH. Endoscopic endonasal management of craniopharyngioma. Otolaryngol Clin North Am. 2016;49:201–12.
Cavallo LM, et al. The endoscopic endonasal approach for the management of craniopharyngiomas: a series of 103 patients. J Neurosurg. 2014;121:100–13.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Couldwell, W.T., Kelly, D.F., Liu, J.K. (2019). 18 Suprasellar Craniopharyngiomas. In: Evans, J., Kenning, T., Farrell, C., Kshettry, V. (eds) Endoscopic and Keyhole Cranial Base Surgery . Springer, Cham. https://doi.org/10.1007/978-3-319-64379-3_18
Download citation
DOI: https://doi.org/10.1007/978-3-319-64379-3_18
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-64378-6
Online ISBN: 978-3-319-64379-3
eBook Packages: MedicineMedicine (R0)