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Clinically Inflammatory Vitiligo and Rare Variants

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Vitiligo

Abstract

A particular form of vitiligo of clinically inflammatory vitiligo has been reported as “inflammatory vitiligo with raised borders” or marginal vitiligo and is associated with lichenoid infiltrates in the margins of progressing lesions. In pigmented progressing borders of common vitiligo/NSV and SV, similar features of lesser intensity have been demonstrated suggesting that most subtypes of vitiligo belong to the spectrum of a clinically silent chronic inflammatory skin disorder responsible for melanocyte loss. Clinically inflammatory vitiligo (CIV) has been sometimes associated with infectious or inflammatory diseases. Other rare variants considered in this chapter include follicular vitiligo, vitiligo/leukoderma guttata, and hypopigmented vitiligo/vitiligo minor. For both CIV and hypopigmented vitiligo, biopsies (sometimes repeated) are needed to establish a firm diagnosis, in particular to exclude cutaneous T-cell lymphoma, a major differential diagnosis.

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References

  1. Taïeb A, Picardo M, VETF Members. The definition and assessment of vitiligo: a consensus report of the Vitiligo European Task Force. Pigment Cell Res. 2007;20:27–35.

    PubMed  Google Scholar 

  2. Buckley W, Lobitz W. Vitiligo with raised inflammatory border. Arch Derm Syph. 1953;67:316–20.

    CAS  Google Scholar 

  3. Garb J, Wise F. Vitiligo with raised borders. Arch Derm Syphilol. 1948;58:149–53.

    CAS  PubMed  Google Scholar 

  4. Wise F. Leukoderma with inflammatory borders. Arch Derm Syph. 1942;45:218–9.

    Google Scholar 

  5. Duvic M, Rapini R, Hoots WK, et al. Human immunodeficiency virus-associated vitiligo: expression of autoimmunity with immunodeficiency? J Am Acad Dermatol. 1987;17:656–62.

    CAS  PubMed  Google Scholar 

  6. Grandhe NP, Dogra S, Kumar B. Spontaneous repigmentation of vitiligo in an untreated HIV-positive patient. J Eur Acad Dermatol Venereol. 2006;20:234–5.

    CAS  PubMed  Google Scholar 

  7. Niamba P, Traoré A, Taieb A. Vitiligo sur peau noire associée au VIH et repigmentation lors du traitement antiretroviral. Ann Dermatol Venereol. 2007;134:272–6.

    CAS  PubMed  Google Scholar 

  8. Tsuboi H, Yonemoto K, Katsuoka K. Vitiligo with inflammatory raised borders with hepatitis C virus infection. J Dermatol. 2006;33:577–8.

    PubMed  Google Scholar 

  9. Weisberg EL, Le LQ, Cohen JB. A case of simultaneously occurring lichen sclerosus and segmental vitiligo: connecting the underlying autoimmune pathogenesis. Int J Dermatol. 2008;47:1053–5.

    PubMed  Google Scholar 

  10. Sugita K, Izu K, Tokura Y. Vitiligo with inflammatory raised borders, associated with atopic dermatitis. Clin Exp Dermatol. 2006;31:80–2.

    CAS  PubMed  Google Scholar 

  11. Tsuruta D, Hamada T, Teramae H, et al. Inflammatory vitiligo in Vogt-Koyanagi-Harada disease. J Am Acad Dermatol. 2001;44:129–31.

    CAS  PubMed  Google Scholar 

  12. Wong SS, Ng SK, Lee HM. Vogt-Koyanagi-Harada Disease: extensive vitiligo with prodromal generalized erythroderma. Dermatology. 1999;198:65–8.

    CAS  PubMed  Google Scholar 

  13. Gunasekera N, Murphy GF, Sheth VM. Repigmentation of extensive inflammatory vitiligo with raised borders using early and aggressive treatment. Dermatology. 2015;230(1):11–5.

    PubMed  Google Scholar 

  14. Michaëlsson G. Vitiligo with raised borders. Report of two cases. Acta Derm Venereol. 1968;48:158–61.

    PubMed  Google Scholar 

  15. Ortonne JP, Baran R, Civatte J. Vitiligo with an inflammatory border. A propos of 2 cases with review of the literature (18 cases). Ann Dermatol Venereol. 1979;106:613–5.

    CAS  PubMed  Google Scholar 

  16. Petit T, Cribier B, Bagot M, Wechsler J. Inflammatory vitiligo-like macules that simulate hypopigmented mycosis fungoides. Eur J Dermatol. 2003;17:410–2.

    Google Scholar 

  17. Swick BL, Walling HW. Depigmented patches with an annular inflammatory border. Clin Exp Dermatol. 2008;33:671–2.

    CAS  PubMed  Google Scholar 

  18. Shin J, Lee JS, Kim MR, Kim do Y, Hann SK, Oh SH. New suggestive clue to the mechanism of vitiligo: inflammatory vitiligo showing prominent leukocytoclasis at the erythematous rim. J Dermatol. 2013;40(6):488–90.

    PubMed  Google Scholar 

  19. Trikha R, McCowan N, Brodell R. Marginal vitiligo: an unusual depigmenting disorder. Dermatol Online J. 2014;21(3):pii: 13030.

    Google Scholar 

  20. Yagi H, Tokura Y, Furukawa Y, Takigawa M. Vitiligo with raised inflammatory borders: involvement of T cell immunity and keratinocytes expressing MHC class II and ICAM-1 molecules. Eur J Dermatol. 1997;7:19–22.

    Google Scholar 

  21. Tanioka M, Takahashi K, Miyachi YI. Narrowband ultraviolet B phototherapy for inflammatory vitiligo with raised borders associated with Sjögren’s syndrome. Clin Exp Dermatol. 2009;34(3):418–20.

    CAS  PubMed  Google Scholar 

  22. Annessi G, Paradisi M, Angelo C, et al. Annular lichenoid dermatitis of youth. J Am Acad Dermatol. 2003;49:1029–36.

    PubMed  Google Scholar 

  23. Attili VR, Attili SK. Lichenoid inflammation in vitiligo-a clinical and histopathologic review of 210 cases. Int J Dermatol. 2008;47:663–9.

    PubMed  Google Scholar 

  24. Hann SK, Park YK, Lee KG, et al. Epidermal changes in active vitiligo. J Dermatol. 1992;19:217–22.

    CAS  PubMed  Google Scholar 

  25. Sharquie KE, Mehenna SH, Naji AA, Al-Azzawi H. Inflammatory changes in vitiligo: stage I and II depigmentation. Am J Dermatopathol. 2004;26:108–12.

    PubMed  Google Scholar 

  26. Attili VR, Attili SK. Segmental and generalized vitiligo: both forms demonstrate inflammatory histopathological features and clinical mosaicism. Indian J Dermatol. 2013;58(6):433–8.

    PubMed  PubMed Central  Google Scholar 

  27. Ezzedine K, Amazan E, Seneschal J, Cario-André M, Léauté-Labrèze C, Vergier B, Boralevi F, Taieb A. Follicular vitiligo: a new form of vitiligo. Pigment Cell Melanoma Res. 2012a;25(4):527–9.

    PubMed  Google Scholar 

  28. Ezzedine K, Amazan E, Séneschal J, Cario-André M, Léauté-Labrèze C, Vergier B, Boralevi F, Taieb A. Follicular vitiligo: a new form of vitiligo. Pigment Cell Melanoma Res. 2012b;25:527–9.

    PubMed  Google Scholar 

  29. Gan EY, Cario-André M, Pain C, Goussot JF, Taïeb A, Seneschal J, Ezzedine K. Follicular vitiligo: a report of 8 cases. J Am Acad Dermatol. 2016;74(6):1178–84.

    PubMed  Google Scholar 

  30. Ezzedine K, Mahé A, van Geel N, Cardot-Leccia N, Gauthier Y, Descamps V, Al Issa A, Ly F, Chosidow O, Taïeb A, Passeron T. Hypochromic vitiligo: delineation of a new entity. Br J Dermatol. 2015;172(3):716–21.

    CAS  PubMed  Google Scholar 

  31. Gameiro A, Gouveia M, Tellechea Ó, Moreno A. Childhood hypopigmented mycosis fungoides: a commonly delayed diagnosis. BMJ Case Rep. 2014;2014:pii: bcr2014208306.

    Google Scholar 

  32. Ranawaka RR, Abeygunasekara PH, de Silva MV. Hypopigmented mycosis fungoides in type v skin: a report of 5 cases. Case Rep Dermatol Med. 2011;2011:190572.

    PubMed  PubMed Central  Google Scholar 

  33. Soro LA, Gust AJ, Purcell SM. Inflammatory vitiligo versus hypopigmented mycosis fungoides in a 58-year-old Indian female. Indian Dermatol Online J. 2013;4(4):321–5.

    PubMed  PubMed Central  Google Scholar 

  34. Tolkachjov SN, Comfere NI. Hypopigmented mycosis fungoides: a clinical mimicker of vitiligo. J Drugs Dermatol. 2015;14(2):193–4.

    PubMed  Google Scholar 

  35. Falabella R, Escobar CE, Carrascal E, Arroyave JA. Leukoderma punctata. J Am Acad Dermatol. 1988;18(3):485–94.

    CAS  PubMed  Google Scholar 

  36. Loquai C, Metze D, Nashan D, Luger TA, Böhm M. Confetti-like lesions with hyperkeratosis: a novel ultraviolet-induced hypomelanotic disorder? Br J Dermatol. 2005;153:190–3.

    CAS  PubMed  Google Scholar 

  37. Verma S, Joshi R. Amyloidosis cutis dyschromica: a rare reticulate pigmentary dermatosis. Indian J Dermatol. 2015;60:385–7.

    PubMed  PubMed Central  Google Scholar 

  38. Taïeb A. Vitiligo as an inflammatory skin disorder: a therapeutic perspective. Pigment Cell Melanoma Res. 2012;25(1):9–13.

    PubMed  Google Scholar 

  39. Levandowski CB, Mailloux CM, Ferrara TM, Gowan K, Ben S, Jin Y, McFann KK, Holland PJ, Fain PR, Dinarello CA, Spritz RA. NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1β processing via the NLRP1 inflammasome. Proc Natl Acad Sci. 2013;110(8):2952–6.

    CAS  PubMed  Google Scholar 

  40. Marie J, Kovacs D, Pain C, Jouary T, Cota C, Vergier B, Picardo M, Taieb A, Ezzedine K, Cario-André M. Inflammasome activation and vitiligo/nonsegmental vitiligo progression. Br J Dermatol. 2014;170(4):816–23.

    CAS  PubMed  Google Scholar 

  41. Mosenson JA, Zloza A, Nieland JD, Garrett-Mayer E, Eby JM, Huelsmann EJ, Kumar P, Denman CJ, Lacek AT, Kohlhapp FJ, Alamiri A, Hughes T, Bines SD, Kaufman HL, Overbeck A, Mehrotra S, Hernandez C, Nishimura MI, Guevara-Patino JA, Le Poole IC. Mutant HSP70 reverses autoimmune depigmentation in vitiligo. Sci Transl Med. 2013;5(174):174ra28.

    PubMed  PubMed Central  Google Scholar 

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Correspondence to Alain Taïeb .

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Taïeb, A., Ezzedine, K., Seneschal, J., Attili, R. (2019). Clinically Inflammatory Vitiligo and Rare Variants. In: Picardo, M., Taïeb, A. (eds) Vitiligo. Springer, Cham. https://doi.org/10.1007/978-3-319-62960-5_8

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  • DOI: https://doi.org/10.1007/978-3-319-62960-5_8

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  • Online ISBN: 978-3-319-62960-5

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