Skip to main content
SpringerLink
Log in

Pathophysiology Overview

  • Chapter
  • First Online:
Book cover Vitiligo

Abstract

Thanks to the advances in technology over the past few years, there has been an ongoing and in-depth study of the genes that make up the human being as a whole and more specifically those involved in pathologies and diseases affecting the general population. So far, over 50 different vitiligo susceptible genes have been identified [1–3]. Gaining a better understanding of the genes involved in vitiligo may in the future lead to a better approach in treating vitiligo and might even allow for disease prevention in genetically susceptible individuals.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Spritz RA, Andersen GH. Genetics of vitiligo. Dermatol Clin. 2017;35(2):245–55. https://doi.org/10.1016/j.det.2016.11.013.

  2. Shen C, Gao J, Sheng Y, Dou J, Zhou F, Zheng X, Ko R, Tang X, Zhu C, Yin X, Sun L, Cui Y, Zhang X. Genetic susceptibility to vitiligo: GWAS approaches for identifying vitiligo susceptibility genes and loci. Front Genet. 2016;7:3. https://doi.org/10.3389/fgene.2016.00003.

  3. Spritz RA. Six decades of vitiligo genetics: genome-wide studies provide insights into autoimmune pathogenesis. J Invest Dermatol. 2012;132(2):268–73. https://doi.org/10.1038/jid.2011.321.

    Article  CAS  PubMed  Google Scholar 

  4. Alkhateeb A, Fain PR, Thody A, Bennett DC, Spritz RA. Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families. Pigment Cell Res. 2003;16(3):208–14.

    Article  PubMed  Google Scholar 

  5. Picardo M, Dell’Anna ML, Ezzedine K, Hamzavi I, Harris JE, Parsad D, Taieb A. Vitiligo. Nat Rev Dis Primers. 2015;1:15011. https://doi.org/10.1038/nrdp.2015.11.

    Article  PubMed  Google Scholar 

  6. Schallreuter KU, Moore J, Wood JM, Beazley WD, Gaze DC, Tobin DJ, Marshall HS, Panske A, Panzig E, Hibberts NA. In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase. J Investig Dermatol Symp Proc. 1999;4(1):91–6.

    Article  CAS  PubMed  Google Scholar 

  7. Bellei B, Pitisci A, Ottaviani M, Ludovici M, Cota C, Luzi F, Dell’Anna ML, Picardo M. Vitiligo: a possible model of degenerative diseases. PLoS One. 2013;8(3):e59782. https://doi.org/10.1371/journal.pone.0059782.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Lee AY. Role of keratinocytes in the development of vitiligo. Ann Dermatol. 2012;24(2):115–25. https://doi.org/10.5021/ad.2012.24.2.115.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Kovacs D, Bastonini E, Ottaviani M, Cota C, Migliano E, Dell’Anna ML, Picardo M. Vitiligo skin: exploring the dermal compartment. J Invest Dermatol. 2018;138:394. https://doi.org/10.1016/j.jid.2017.06.033.. pii: S0022-202X(17)33029-4.

    Article  CAS  Google Scholar 

  10. Boniface K, Seneschal J, Picardo M, Taïeb A. Vitiligo: focus on clinical aspects, immunopathogenesis, and therapy. Clin Rev Allergy Immunol. 2018;54:52. https://doi.org/10.1007/s12016-017-8622-7.

    Article  CAS  Google Scholar 

  11. Harris JE, Harris TH, Weninger W, Wherry EJ, Hunter CA, Turka LA. A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8+ T-cell accumulation in the skin. J Invest Dermatol. 2012;132(7):1869–76. https://doi.org/10.1038/jid.2011.463.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Dwivedi M, Kemp EH, Laddha NC, Mansuri MS, Weetman AP, Begum R. Regulatory T cells in vitiligo: implications for pathogenesis and therapeutics. Autoimmun Rev. 2015;14(1):49–56.

    Article  CAS  PubMed  Google Scholar 

  13. van Geel N, Speeckaert R. Segmental vitiligo. Dermatol Clin. 2017;35(2):145–50. https://doi.org/10.1016/j.det.2016.11.005.

    Article  CAS  PubMed  Google Scholar 

  14. Becatti M, Prignano F, Fiorillo C, Pescitelli L, Nassi P, Lotti T, Taddei N. The involvement of Smac/DIABLO, p53, NF-kB, and MAPK pathways in apoptosis of keratinocytes from perilesional vitiligo skin: protective effects of curcumin and capsaicin. Antioxid Redox Signal. 2010;13(9):1309–21. https://doi.org/10.1089/ars.2009.2779.

    Article  CAS  PubMed  Google Scholar 

  15. Shi F, Kong BW, Song JJ, Lee JY, Dienglewicz RL, Erf GF. Understanding mechanisms of vitiligo development in Smyth line of chickens by transcriptomic microarray analysis of evolving autoimmune lesions. BMC Immunol. 2012;13:18. https://doi.org/10.1186/1471-2172-13-18.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Rashighi M, Agarwal P, Richmond JM, Harris TH, Dresser K, Su MW, Zhou Y, Deng A, Hunter CA, Luster AD, Harris JE. CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo. Sci Transl Med. 2014;6(223):223ra23. https://doi.org/10.1126/scitranslmed.3007811.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Eby JM, Kang HK, Klarquist J, Chatterjee S, Mosenson JA, Nishimura MI, Garrett-Mayer E, Longley BJ, Engelhard VH, Mehrotra S, Le Poole IC. Immune responses in a mouse model of vitiligo with spontaneous epidermal de- and repigmentation. Pigment Cell Melanoma Res. 2014;27(6):1075–85. https://doi.org/10.1111/pcmr.12284.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cutaneous Physiopathology and CIRM, San Gallicano Dermatological Institute, IRCCS, Rome, Italy

    Mauro Picardo

Authors
  1. Mauro Picardo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mauro Picardo .

Editor information

Editors and Affiliations

  1. Cutaneous Physiopathology & CIRM, San Gallicano Dermatological Institute, Rome, Italy

    Mauro Picardo

  2. Hôpital Saint André, Service de Dermatologie Adulte et Pédiatrique, INSERM U 1035, Université de Bordeaux, Bordeaux, France

    Alain Taïeb

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Picardo, M. (2019). Pathophysiology Overview. In: Picardo, M., Taïeb, A. (eds) Vitiligo. Springer, Cham. https://doi.org/10.1007/978-3-319-62960-5_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-62960-5_20

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-62958-2

  • Online ISBN: 978-3-319-62960-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation