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Oncoplastic and Reconstructive Breast Surgery pp 179–194Cite as

Adjuvant Systemic Therapy in Breast Cancer

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Abstract

Patients with early-stage breast cancer are treated with curative intent. The goal of adjuvant therapy is to improve overall survival [1, 2]. After surgery, although there is no evidence of gross remaining disease, patients still have a risk of relapse from occult micrometastatic disease. The goal of adjuvant systemic therapy is to decrease risk of recurrence while minimizing toxicities and overtreatment. Therefore, it is important to identify patient populations that will benefit most from treatment in order to avoid unnecessary toxicities [3–5]. Patients require different adjuvant therapies based on their risk of recurrence, stage of disease, and tumor biology. In this chapter, we will discuss systemic adjuvant therapy including endocrine therapy, chemotherapy, and HER2-targeted therapy [6, 7].

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Authors and Affiliations

  1. Department of Medicine, Epidemiology and Bioestatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Shari GoldFarb

  2. Department of Medicine, Weill Cornell Medical Center, New York, NY, USA

    Shari GoldFarb

  3. Departments of Medicine and Regional Network, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Wanqing Iris Zhi

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  1. Shari GoldFarb
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  2. Wanqing Iris Zhi
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Correspondence to Shari GoldFarb .

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Editors and Affiliations

  1. Our Lady of Grace Hospital, Positivo University, Curitiba, Brazil

    Cicero Urban

  2. Plastic and Reconstructive Division, European Institute of Oncology, Milan, Italy

    Mario Rietjens

  3. Memorial Sloan Kettering Cancer Center, New York, USA

    Mahmoud El-Tamer

  4. Memorial Sloan Kettering Cancer Center, New York, USA

    Virgilio S. Sacchini

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GoldFarb, S., Zhi, W.I. (2019). Adjuvant Systemic Therapy in Breast Cancer. In: Urban, C., Rietjens, M., El-Tamer, M., Sacchini, V.S. (eds) Oncoplastic and Reconstructive Breast Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-62927-8_13

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