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Malignant and Benign Diseases of the Eye and Orbit

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Abstract

This chapter will discuss uveal melanoma, ocular lymphoma, intraocular lymphoma, thyroid ophthalmopathy, and orbital lymphoid hyperplasia (for Retinoblastoma and Rhabdomyosarcoma, see Chap. 41).

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References

  • Akpek E, et al. Intraocular-central nervous system lymphoma: clinical features, diagnosis, and outcomes. Ophthalmology. 1999;106:1805–10.

    Article  CAS  Google Scholar 

  • Aziz HA, Singh N, Bena J, Wilkinson A, Singh AD. Vision loss following episcleral brachytherapy for uveal melanoma: development of a vision prognostication tool. JAMA ophthalmology. 2016;134(6):615–20.

    Article  Google Scholar 

  • Bell D, et al. Choroidal melanoma: natural history and management options. Cancer Control. 2004;11(5):296–303.

    Article  Google Scholar 

  • Berenbom A, Davila RM, Lin H-S, et al. Treatment outcomes for primary intraocular lymphoma: implications for external beam radiotherapy. Eye. 2007;21:1198–201.

    Article  CAS  Google Scholar 

  • Bhatia S, et al. Curative radiotherapy for primary orbital lymphoma. Int J Radiat Oncol Biol Phys. 2002;54:818–21.

    Article  Google Scholar 

  • Bolek T, et al. Radiotherapy in the management of orbital lymphoma. Int J Radiat Oncol Biol Phys. 1999;44:31–6.

    Article  CAS  Google Scholar 

  • Bradley EA, Gower EW, Bradley DJ, et al. Orbital radiation for graves ophthalmopathy. Ophthalmology. 2008;115:398–409.

    Article  Google Scholar 

  • Chan C, Wallace D. Intraocular lymphoma: update on diagnosis and management. Cancer Control. 2004;11(5):285–95.

    Article  Google Scholar 

  • Chang MY, McCannel TA. Local treatment failure after globe- conserving therapy for choroidal melanoma. Br J Ophthalmol. 2013;97:804–11.

    Article  Google Scholar 

  • Char D, et al. Primary intraocular lymphoma (ocular reticulum cell sarcoma) diagnosis and management. Ophthalmology. 1988;95:625–30.

    Article  CAS  Google Scholar 

  • Char D, Quivey J, et al. Helium ions versus I-125 brachytherapy in management of uveal melanoma. A prospective, dynamically balanced trial. Ophthalmology. 1993;100:1547–54.

    Article  CAS  Google Scholar 

  • Choudhary MM, Gupta A, Bena J, Emch T, Singh AD. Hepatic ultrasonography for surveillance in pts with uveal melanoma. JAMA Ophthalmol. 2016;134(2):174–80.

    Article  Google Scholar 

  • COMS. Mortality in pts with small choroidal melanoma. COMS report no. 4. Arch Ophthalmol. 1997;115:886.

    Article  Google Scholar 

  • COMS. The COMS randomized trial of pre-enucleation radiation of large choroidal melanoma: IV. Ten-year mortality findings and prognostic factors. COMS report no 24. Am J Ophthalmol. 2004;138(6):936.

    Article  Google Scholar 

  • COMS. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: V. Twelve-year mortality rates and prognostic factors: COMS report no. 28. Arch Ophthalmol. 2006;124:1684.

    Article  Google Scholar 

  • Daftari I, et al. Newer radiation modalities for choroidal tumors. Int Ophthal Clin. 2006;46:69.

    Article  Google Scholar 

  • Diener-West M, et al. Screening for metastasis from choroidal melanoma: the COMS group report 23. J Clin Oncol. 2004;22:2438–44.

    Article  Google Scholar 

  • Diener-West M, et al. Development of metastatic disease after enrollment in the COMS trials for treatment of choroidal melanoma: COMS report no. 26. Arch Ophthalmol. 2005;123(12):1639.

    Article  Google Scholar 

  • Egger E, et al. Maximizing local tumor control and survival after proton beam radiotherapy of uveal melanoma. Int J Radiat Oncol Biol Phys. 2001;51:138.

    Article  CAS  Google Scholar 

  • Esik O, et al. Retrospective analysis of different modalities for treatment of primary orbital non-Hodgkin’s lymphomas. Radiother Oncol. 1996;38:13–8.

    Article  CAS  Google Scholar 

  • Fasola CE, Jones JC, Huang DD, Le QT, Hoppe RT, Donaldson SS. Low-dose radiation therapy (2 Gy× 2) in the treatment of orbital lymphoma. Int J Radiat Oncol Biol Phys. 2013;86(5):930–5.

    Article  Google Scholar 

  • Force, Task, and ABS–OOTF Committee. The American brachytherapy society consensus guidelines for plaque brachytherapy of uveal melanoma and retinoblastoma. Brachytherapy. 2014;13(1):1–14.

    Article  Google Scholar 

  • Gragoudas ES. Proton beam irradiation of uveal melanomas: the first 30 years. Invest Ophthalmol Vis Sci. 2006;47:4666–73.

    Article  Google Scholar 

  • Gragoudas ES, et al. A randomized controlled trial of varying radiation doses in the treatment of choroidal melanoma. Arch Ophthalmol. 2000;118:773.

    Article  CAS  Google Scholar 

  • Grimm SA, et al. Primary intraocular lymphoma: an international primary central nervous system lymphoma collaborative group report. Ann Oncol. 2007;18:1851–5.

    Article  CAS  Google Scholar 

  • Hoffman PM, et al. Intraocular lymphoma: a series of 14 pts with clinicopathological features and treatment outcomes. Eye. 2003;17:513–21.

    Article  CAS  Google Scholar 

  • Hrbacek J, Mishra KK, Kacperek A, et al. Practice patterns analysis of ocular proton therapy centers: the international OPTIC survey. Int J Radiat Oncol Biol Phys. 2016;95:336–43.

    Article  Google Scholar 

  • Illidge T, Specht L, Yahalom J, Aleman B, Berthelsen AK, Constine L, Dabaja B, Dharmarajan K, Ng A, Ricardi U, Wirth A. Modern radiation therapy for nodal non-hodgkin lymphoma—target definition and dose guidelines from the international lymphoma radiation oncology group. Int J Radiat Oncol Biol Phys. 2014;89(1):49–58.

    Article  Google Scholar 

  • Jeganathan V, Swetha E, Wirth A, MacManus MP. Ocular risks from orbital and periorbital radiation therapy: a critical review. Int J Radiat Oncol Biol Phys. 2011;79(3):650–9.

    Article  Google Scholar 

  • Kath R, et al. Prognosis and treatment of disseminated uveal melanoma. Cancer. 1993;72(7):2219–23.

    Article  CAS  Google Scholar 

  • Kujala E, et al. Very long term prognosis of pts with malignant uveal melanoma. Invest Ophthalmol Vis Sci. 2003;44:4651–9.

    Article  Google Scholar 

  • Lanciano R, et al. The results of radiotherapy for orbital pseudotumor. Int J Radiat Oncol Biol Phys. 1990;18:407.

    Article  CAS  Google Scholar 

  • Lane AM, Kim IK, Gragoudas ES. Long-term risk of melanoma-related mortality for pts with uveal melanoma treated with proton beam therapy. JAMA Ophthalmol. 2015;133(7):792–6.

    Article  Google Scholar 

  • Le Q, et al. Primary radiotherapy for localized orbital malt lymphoma. Int J Radiat Oncol Biol Phys. 2002;52:657–63.

    Article  Google Scholar 

  • Marucci L, Lane AM, Li W, et al. Conservation treatment of the eye: conformal proton reirradiation for recurrent uveal melanoma. Int J Radiat Oncol Biol Phys. 2006;64:1018–22.

    Article  Google Scholar 

  • Mishra KK, Quivey JM, Daftari IK, Weinberg V, Cole T, Patel K, Castro JR, Phillips TL, Char DH. Long-term results of the UCSF-LBNL randomized trial: charged particle with helium ion versus iodine-125 plaque therapy for choroidal and ciliary body melanoma. Int J Radiat Oncol Biol Phys. 2015a;92(2):376–83.

    Article  Google Scholar 

  • Muller K, Naus N, Nowak PJCM, Schmitz PIM, De Pan C, Van Santen CA, et al. Fractionated stereotactic radiotherapy for uveal melanoma, late clinical results. Radiother Oncol. 2012;102:219–24.

    Article  Google Scholar 

  • Nag S, et al. The American brachytherapy society recommendations for brachytherapy of uveal melanomas. Int J Radiat Oncol Biol Phys. 2003;56:544.

    Article  Google Scholar 

  • Nathan P, et al. Uveal melanoma UK national guidelines. Eur J Cancer. 2015;51(16):2404–12.

    Article  CAS  Google Scholar 

  • Nguyen LN, Ang K. The orbit. In: Cox J, Ang K, editors. Radiation oncology. 8th ed. St. Louis: Mosby; 2003. p. 282–92.

    Google Scholar 

  • Pelloski CE, et al. Clinical stage IEA-IIEA orbital lymphomas: outcomes in the era of modern staging and treatment. Radiother Oncol. 2001;59:145–51.

    Article  CAS  Google Scholar 

  • Peterson IA, et al. Prognostic factors in the radiotherapy of graves’ ophthalmopathy. Int J Radiat Oncol Biol Phys. 1990;19:259–64.

    Article  Google Scholar 

  • Peterson K, et al. The clinical spectrum of ocular lymphoma. Cancer. 1993;72:843–9.

    Article  CAS  Google Scholar 

  • Pfeffer MR, Rabin T, Tsvang L, et al. Orbital lymphoma: is it necessary to treat the entire orbit? Int J Radiat Oncol Biol Phys. 2004;60:527–30.

    Article  Google Scholar 

  • Prabhu RS, Kandula S, Liebman L, Wojno TH, Hayek B, Hall WA, Shu HK, Crocker I.Association of clinical response and long-term outcome among patients with biopsied orbital pseudotumor receiving modern radiation therapy. Int J Radiat Oncol Biol Phys. 2013;85(3):643–9.

    Article  Google Scholar 

  • Prummel M, et al. Randomized double-blind trial of prednisone versus radiotherapy in graves’ ophthalmopathy. Lancet. 1993;342:949–54.

    Article  CAS  Google Scholar 

  • Prummel MF, Terwee CB, Gerding MN, et al. A randomized controlled trial of orbital radiotherapy versus sham irradiation in pts with mild graves’ ophthalmopathy. J Clin Endocrinol Metab. 2004;89:15–20.

    Article  CAS  Google Scholar 

  • Quivey J, Char D, et al. High intensity 125-iodine (125I) plaque treatment of uveal melanoma. Int J Radiat Oncol Biol Phys. 1993;26(4):613–8.

    Article  CAS  Google Scholar 

  • Rosenthal S. Benign disease. In: Leibel SA, Phillips TL, editors. Textbook of radiation oncology. 2nd ed. Philadelphia: Saunders; 2004. p. 1525–43.

    Google Scholar 

  • Shields C, Shields J. Diagnosis and management of retinoblastoma. Cancer Control. 2004;11(5):317–27.

    Article  Google Scholar 

  • Shields CL, et al. Plaque radiotherapy for uveal melanoma: long-term visual outcome in 1106 consecutive patients. Arch Ophthalmol. 2000;118(9):1219–28.

    Article  CAS  Google Scholar 

  • Shields J, et al. Survey of 1264 pts with orbital tumors and simulating lesions. Ophthalmology. 2004;111:997–1008.

    Article  Google Scholar 

  • Stafford SL, et al. Orbital lymphoma: radiotherapy outcome and complications. Radiother Oncol. 2001;59:139–44.

    Article  CAS  Google Scholar 

  • Straatsma BR, Diener-West M, Caldwell R, Engstrom RE. Mortality after deferral of treatment or no treatment for choroidal melanoma. Am J Ophthalmol. 2003;136(1):47–54.

    Article  Google Scholar 

  • Teckie S, Yahalom J. Primary intraocular lymphoma: treatment outcomes with ocular radiation therapy alone. Leuk Lymphoma. 2014;55(4):795–801.

    Article  CAS  Google Scholar 

  • Verma V, Mehta MP. Clinical outcomes of proton radiotherapy for uveal melanoma. Clin Oncol. 2016;28(8):e17–27.

    Article  CAS  Google Scholar 

  • Weber DC, Bogner J, Verwey J, et al. Proton beam radiotherapy versus fractionated stereotactic radiotherapy for uveal melanomas: a comparative study. Int J Radiat Oncol Biol Phys. 2005;63:373–84.

    Article  Google Scholar 

  • Woolf DK, et al. Outcomes of primary lymphoma of the ocular adnexa (orbital lymphoma) treated with radiotherapy. Clin Oncol. 2015;27(3):153–9.

    Article  CAS  Google Scholar 

  • Zytkovicz A, et al. Peripheral dose in ocular treatments with cyberknife and gamma knife radiosurgery compared to proton radiotherapy. Phys Med Biol. 2007;52(19):5957.

    Article  CAS  Google Scholar 

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Acknowledgment

We thank Tania Kaprealian MD, Alice Wang-Chesebro MD, and Jeanne Marie Quivey MD, FACR, for their work on the prior edition of this chapter.

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Correspondence to Kavita K. Mishra .

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Chan, J., Mishra, K.K. (2018). Malignant and Benign Diseases of the Eye and Orbit. In: Hansen, E., Roach III, M. (eds) Handbook of Evidence-Based Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-62642-0_3

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  • DOI: https://doi.org/10.1007/978-3-319-62642-0_3

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