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Oral Cancer Detection pp 189–204Cite as

Optical Imaging in Oral Oncology

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Abstract

There has been widespread interest in the application of simple light-based methods and optical imaging as adjunctive tools in oral oncology. These optical imaging techniques exploit differences in properties such as absorption, reflectance, and light scattering between normal and transformed epithelium. Optical imaging methods can also utilize tissue autofluorescence arising from endogenous chromatophores to detect malignant tissue. For example, early oral malignancy is often associated with a loss of fluorescence or fluorescence visualization loss (FVL) which may be used to aid in tissue selection for biopsy. The autofluorescence-based Visual Enhanced Light scope (VELscope®), chemiluminescence-based ViziLite® system, the Identafi® system that uses multispectral fluorescence and reflectance, and narrow band imaging (NBI) instruments are among the optical imaging-based diagnostic platforms that are currently available for clinical use. In addition, photoacoustic imaging (PAI) is an advanced hybrid imaging method that allows for deep tissue imaging and is actively being evaluated for diagnostic applications in oncology. In this chapter, we will review the basics of these optical imaging methods and summarize preclinical and clinical evidence on their performance in oral oncology. The goal of this chapter is to provide the reader with an overview of these methods and their potential clinical applications.

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Acknowledgments

Support from R01CA204636, R01DE024595, S10OD010393-01, and P30CA06156 is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Oral Medicine and Radiology, MNR Dental College and Hospital, Sangareddy, Telangana, India

    Prashanth Panta MDS

  2. Department of Oral Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA

    Laurie J. Rich PhD & Mukund Seshadri DDS, PhD

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  1. Prashanth Panta MDS
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Correspondence to Prashanth Panta MDS .

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  1. Depatment of Oral Medicine and Radiology, MNR Dental College Oral Medicine and Radiology, Hyderabad, India

    Prashanth Panta

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Panta, P., Rich, L.J., Seshadri, M. (2019). Optical Imaging in Oral Oncology. In: Panta, P. (eds) Oral Cancer Detection. Springer, Cham. https://doi.org/10.1007/978-3-319-61255-3_9

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