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Oral Cancer Screening: Application of Vital Stains as Adjuncts to Clinical Examination

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Oral Cancer Detection

Abstract

An essential first line of investigation in oral oncology is clinical examination of high-risk oral sites. Given the elevated DNA content in cancers, vital dyes such as toluidine blue, methylene blue, Lugol’s iodine, and rose bengal, which have an inherent chemical capacity to bind to DNA, have been studied for their clinical utility in screening malignant changes in the oral cavity. In this chapter, we cover the basics of clinical examination and review the literature on the use of vital stains as adjunct diagnostic aids in patients with clinically suspicious oral lesions such as leukoplakia and erythroplakia. The goal of this chapter is to provide the reader with an overview of the vital stains available on the market and their potential for clinical application. A discussion of their strengths, limitations, and the rationale for development of new screening methods, has also been provided.

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Acknowledgments

Support from R01CA204636, R01DE024595, and P30CA06156 is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Oral Medicine and Radiology, MNR Dental College and Hospital, Sangareddy, Telangana, India

    Prashanth Panta MDS

  2. Department of Oral Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA

    Laurie J. Rich PhD & Mukund Seshadri DDS, PhD

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  1. Prashanth Panta MDS
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  2. Laurie J. Rich PhD
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  3. Mukund Seshadri DDS, PhD
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Correspondence to Prashanth Panta MDS .

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Editors and Affiliations

  1. Depatment of Oral Medicine and Radiology, MNR Dental College Oral Medicine and Radiology, Hyderabad, India

    Prashanth Panta

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Panta, P., Rich, L.J., Seshadri, M. (2019). Oral Cancer Screening: Application of Vital Stains as Adjuncts to Clinical Examination. In: Panta, P. (eds) Oral Cancer Detection. Springer, Cham. https://doi.org/10.1007/978-3-319-61255-3_7

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  • DOI: https://doi.org/10.1007/978-3-319-61255-3_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-61254-6

  • Online ISBN: 978-3-319-61255-3

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