Skip to main content

Upper and Lower Gastrointestinal Bleeding

  • Chapter
  • First Online:
Surgical Management of Elderly Patients

Abstract

More than 1% of people aged 80 years and older are hospitalized each year because of gastrointestinal bleeding, and rates of both upper and lower GI hemorrhages increase significantly with aging. Gastrointestinal bleeding in such elderly people can originate from lesions common to all age groups or from lesions associated specifically with aging. Although the approach to the diagnosis and management of gastrointestinal bleeding is not specific to elderly people, elderly people differ from younger people in the same conditions for several aspects of clinical presentation and outcomes. In elderly people, morbidity and mortality from GI bleeding are determined by both the nature and the entity of bleeding and by the presence of comorbid medical conditions, including cardiovascular and pulmonary disease; furthermore, they are commonly prescribed numerous medications which may compromise mucosal integrity and predispose bleeding (aspirin, NSAID, anticoagulant, and antiplatelet medications). In this chapter, clinical presentation, etiology, risk factors, diagnostic tools, and management in upper and lower gastrointestinal bleeding are explained.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  1. Kaplan RC, et al. Risk factors for hospitalized gastrointestinal bleeding among older persons. J Am Geriatr Soc. 2001;49:126–33.

    Article  CAS  Google Scholar 

  2. Constantini TW, Kobayashi LM, Coimbra R. Intestinal hemorrhage in elderly. In: Yelon JA, Luchette FA, editors. Geriatric trauma e critical care. New York: Springer Science+Business Media; 2014. p. 145–54.

    Chapter  Google Scholar 

  3. Yachimski PS, Friedman LS. Gastrointestinal bleeding in the elderly. Nat Clin Pract Gastroenterol Hepatol. 2008;5(2):80–93. https://doi.org/10.1038/ncpgasthep1034.

    Article  PubMed  Google Scholar 

  4. Farrell JJ, Friedman LS. Gastrointestinal bleeding in older people. Gastroenterol Clin N Am. 2000;29:1–36.

    Article  CAS  Google Scholar 

  5. Nikolsky E, Mehran R, Stone GW. Gastrointestinal bleeding in percutaneous coronary intervention and acute coronary syndromes. Am J Cardiol. 2009;104(5 Suppl):22C–9.

    Article  Google Scholar 

  6. Hylek EM, Evans-Molina C, Shea C, Henault LE, Regan S. Major hemorrhage and tolerability of warfarin in the first year of therapy among elderly patients with atrial fibrillation. Circulation. 2007;115(21):2689–96.

    Article  CAS  Google Scholar 

  7. Wierzchowski P. Urgent endoscopy in elderly patients with non-variceal upper gastrointestinal bleeding. Videosurg Other Miniinvasive Tech. 2012;7(4):246–50. https://doi.org/10.5114/wiitm.2011.28907.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Rockall TA, et al. Incidence of and mortality from acute upper gastrointestinal haemorrhage in the United Kingdom. Steering Committee and members of the national audit of acute upper gastrointestinal hemorrhage. BMJ. 1995;311:222–6.

    Article  CAS  Google Scholar 

  9. Longstreth GF. Epidemiology of hospitalization for acute upper gastrointestinal hemorrhage: a population-based study. Am J Gastroenterol. 1995;90:206–10.

    CAS  PubMed  Google Scholar 

  10. Seinela L, Ahvenainen J. Peptic ulcer in the very old patients. Gerontology. 2000;46:271–5.

    Article  CAS  Google Scholar 

  11. Kemppainen H, Raiha I, Sourander L. Clinical presentation of peptic ulcer in the elderly. Gerontology. 1997;43:283–8.

    Article  CAS  Google Scholar 

  12. Pilotto A, Maggi S, Noale M, et al. Development and validation of a new questionnaire for the evaluation of upper gastrointestinal symptoms in the elderly population: a multicenter study. J Gerontol A Biol Sci Med Sci. 2010;65:174–8.

    Article  Google Scholar 

  13. Longstreth GF. Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal hemorrhage: a population-based study. Am J Gastroenterol. 1997;92(3):419–24.

    CAS  PubMed  Google Scholar 

  14. Higham J, Kang JY, Majeed A. Recent trends in admissions and mortality due to peptic ulcer in England: increasing frequency of haemorrhage among older subjects. Gut. 2002;50:460–4.

    Article  CAS  Google Scholar 

  15. Kyaw MH, Chan FK. Pharmacologic options in the management of upper gastrointestinal bleeding: focus on the elderly. Drugs Aging. 2014;31(5):349–61.

    Article  CAS  Google Scholar 

  16. Newton JL. Improving the gastrointestinal tolerability of aspirin in older people. Clin Interv Aging. 2006;1:33–9.

    Article  CAS  Google Scholar 

  17. Cryer B, Lee E, Feldman M. Factors influencing gastroduodenal mucosal prostaglandin concentrations: roles of smoking and aging. Ann Intern Med. 1992;116:636–40.

    Article  CAS  Google Scholar 

  18. Goto H, Sugiyama S, Ohara A, et al. Age-associated decreases in prostaglandin contents in human gastric mucosa. Biochem Biophys Res Commun. 1992;186:1443–8.

    Article  CAS  Google Scholar 

  19. Guslandi M, Pellegrini A, Sorghi M. Gastric mucosal defences in the elderly. Gerontology. 1999;45:206–8.

    Article  CAS  Google Scholar 

  20. Kim SW, Parekh D, Townsend CM Jr, et al. Effects of aging on duodenal bicarbonate secretion. Ann Surg. 1990;212:332–7; discussion 337–8

    Article  CAS  Google Scholar 

  21. Brogna A, Ferrara R, Bucceri AM, et al. Influence of aging on gastrointestinal transit time: an ultrasonographic and radiologic study. Investig Radiol. 1999;34:357–9.

    Article  CAS  Google Scholar 

  22. Scheiman JM, Yeomans ND, Talley NJ, et al. Prevention of ulcers by esomeprazole in at-risk patients using non-selective NSAIDs and COX-2 inhibitors. Am J Gastroenterol. 2006;101:701–10.

    Article  CAS  Google Scholar 

  23. Rostom A, Dube C, Wells G, et al. Prevention of NSAID-induced gastroduodenal ulcers. Cochrane Database Syst Rev. 2002;4:CD002296.

    Google Scholar 

  24. Yeomans ND, Tulassay Z, Juhasz L, et al. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs: acid suppression trial: ranitidine versus omeprazole for NSAID-associated ulcer treatment (ASTRONAUT) study group. N Engl J Med. 1998;338:719–26.

    Article  CAS  Google Scholar 

  25. Ishihara M, Ito M. Influence of aging on gastric ulcer healing activities of cimetidine and omeprazole. Eur J Pharmacol. 2002;444:209–15.

    Article  CAS  Google Scholar 

  26. Maggio M, Corsonello A, Ceda GP, et al. Proton pump inhibitors and risk of 1-year mortality and rehospitalization in older patients discharged from acute care hospitals. JAMA Intern Med. 2013;173:518–23.

    Article  Google Scholar 

  27. Deshpande A, Pant C, Pasupuleti V, et al. Association between proton pump inhibitor therapy and Clostridium difficile infection in a meta-analysis. Clin Gastroenterol Hepatol. 2012;10:225–33.

    Article  CAS  Google Scholar 

  28. Johnstone J, Nerenberg K, Loeb M. Meta-analysis: proton pump inhibitor use and the risk of community-acquired pneumonia. Aliment Pharmacol Ther. 2010;31:1165–77.

    Article  CAS  Google Scholar 

  29. Ngamruengphong S, Leontiadis GI, Radhi S, et al. Proton pump inhibitors and risk of fracture: a systematic review and metaanalysis of observational studies. Am J Gastroenterol. 2011;106:1209–18; quiz 1219

    Article  CAS  Google Scholar 

  30. Ahmed A, Stanley AJ. Acute upper gastrointestinal bleeding in the elderly: aetiology, diagnosis and treatment. Drugs Aging. 2012;29(12):933–40. https://doi.org/10.1007/s40266-012-0020-5.

    Article  CAS  PubMed  Google Scholar 

  31. Hosking SW, et al. Management of bleeding varices in the elderly. BMJ. 1989;298:152–3.

    Article  CAS  Google Scholar 

  32. Bergqvist D, et al. Secondary aortoenteric fistulate—changes from 1973 to 1993. Eur J Endovasc Surg. 1996;11:425–8.

    Article  CAS  Google Scholar 

  33. Cendan JC, et al. Twenty-one cases of aortoenteric fistula: lessons for the general surgeon. Am Surg. 2004;70:583–7.

    PubMed  Google Scholar 

  34. Rockall TA, Logan RFA, Devlin HB, et al. Risk assessment after acute upper gastrointestinal haemorrhage. Gut. 1996;38:316–21.

    Article  CAS  Google Scholar 

  35. Blatchford O, Murray WR, Blatchford M. A risk score to predict need for treatment of upper gastrointestinal haemorrhage. Lancet. 2000;356:1318–21.

    Article  CAS  Google Scholar 

  36. Wang CY, Qin J, Wang J, Sun CY, Cao T, Zhu DD. Rockall score in predicting outcomes of elderly patients with acute upper gastrointestinal bleeding. World J Gastrointest Endosc. 2010;2(5):147–54. https://doi.org/10.4253/wjge.v2.i5.147.38.

    Article  Google Scholar 

  37. Chait MM. Lower gastrointestinal bleeding in the elderly. World J Gastrointest Endosc. 2010;2(5):147–54. https://doi.org/10.4253/wjge.v2.i5.147.

    Article  PubMed  PubMed Central  Google Scholar 

  38. McGuire HH Jr. Bleeding colonic diverticula. A reappraisal of natural history and management. Ann Surg. 1994;220(5):653–6.

    Article  Google Scholar 

  39. Comay D, Marshall JK. Resource utilization for acute lower gastrointestinal hemorrhage: the Ontario GI bleed study. Can J Gastroenterol. 2002;16:677–82.

    Article  Google Scholar 

  40. Ríos A, Montoya MJ, Rodríguez JM, Serrano A, Molina J, Parrilla P. Acute lower gastrointestinal hemorrhages in geriatric patients. Dig Dis Sci. 2005;50:898–904.

    Article  Google Scholar 

  41. Rockey DC. Lower gastrointestinal bleeding. Gastroenterology. 2006;130:165–71.

    Article  Google Scholar 

  42. Rhee JC, Lee KT. The causes and management of lower GI bleeding: a study based on clinical observations at Hanyang University Hospital. Gastroenterol Jpn. 1991;26(Suppl 3):101–6.

    PubMed  Google Scholar 

  43. Bokhari M, Vernava AM, Ure T, Longo WE. Diverticular hemorrhage in the elderly—is it well tolerated? Dis Colon Rectum. 1996;39:191–5.

    Article  CAS  Google Scholar 

  44. Stollman N, Raskin JB. Diverticular disease of the colon. Lancet. 2004;363:631–9.

    Article  Google Scholar 

  45. Reinus JF, Brandt LJ. Vascular ectasias and diverticulosis. Common causes of lower intestinal bleeding. Gastroenterol Clin N Am. 1994;23:1–20.

    CAS  Google Scholar 

  46. Boley SJ, Sammartano R, Adams A, DiBiase A, Kleinhaus S, Sprayregen S. On the nature and etiology of vascular ectasias of the colon. Degenerative lesions of aging. Gastroenterology. 1977;72:650–60.

    CAS  PubMed  Google Scholar 

  47. Imperiale TF, Ransohoff DF. Aortic stenosis, idiopathic gastrointestinal bleeding, and angiodysplasia: is there an association? A methodologic critique of the literature. Gastroenterology. 1988;95:1670–6.

    Article  CAS  Google Scholar 

  48. Lindner AE. Inflammatory bowel disease in the elderly. Clin Geriatr Med. 1999;15:487–97.

    CAS  PubMed  Google Scholar 

  49. Robertson DJ, Grimm IS. Inflammatory bowel disease in the elderly. Gastroenterol Clin N Am. 2001;30:409–26.

    Article  CAS  Google Scholar 

  50. Robert JH, Sachar DB, Aufses AH Jr, Greenstein AJ. Management of severe hemorrhage in ulcerative colitis. Am J Surg. 1990;159:550–5.

    Article  CAS  Google Scholar 

  51. Medina C, Vilaseca J, Videla S, Fabra R, Armengol-Miro JR, Malagelada JR. Outcome of patients with ischemic colitis: review of fifty-three cases. Dis Colon Rectum. 2004;47:180–4.

    Article  Google Scholar 

  52. Lew JF, Glass RI, Gangarosa RE, Cohen IP, Bern C, Moe CL. Diarrheal deaths in the United States, 1979 through 1987. A special problem for the elderly. JAMA. 1991;265:3280–4.

    Article  CAS  Google Scholar 

  53. Guerrant RL, Van Gilder T, Steiner TS, Thielman NM, Slutsker L, Tauxe RV, Hennessy T, Griffin PM, DuPont H, Sack RB, Tarr P, Neill M, Nachamkin I, Reller LB, Osterholm MT, Bennish ML, Pickering LK. Practice guidelines for the management of infectious diarrhea. Clin Infect Dis. 2001;32:331–51.

    Article  CAS  Google Scholar 

  54. Slotwiner-Nie PK, Brandt LJ. Infectious diarrhea in the elderly. Gastroenterol Clin N Am. 2001;30:625–35.

    Article  CAS  Google Scholar 

  55. Peura DA, Lanza FL, Gostout CJ, Foutch PG. The American College of Gastroenterology bleeding registry: preliminary findings. Am J Gastroenterol. 1997;92:924–8.

    CAS  PubMed  Google Scholar 

  56. Richter JM, Christensen MR, Kaplan LM, Nishioka NS. Effectiveness of current technology in the diagnosis and management of lower gastrointestinal hemorrhage. Gastrointest Endosc. 1995;41:93–8.

    Article  CAS  Google Scholar 

  57. Kim HS, Kim TI, Kim WH, Kim YH, Kim HJ, Yang SK, Myung SJ, Byeon JS, Lee MS, Chung IK, Jung SA, Jeen YT, Choi JH, Choi KY, Choi H, Han DS, Song JS. Risk factors for immediate postpolypectomy bleeding of the colon: a multicenter study. Am J Gastroenterol. 2006;101:1333–41.

    Article  Google Scholar 

  58. Mühldorfer SM, Kekos G, Hahn EG, Ell C. Complications of therapeutic gastrointestinal endoscopy. Endoscopy. 1992;24:276–83.

    Article  Google Scholar 

  59. Rex DK, Lewis BS, Waye JD. Colonoscopy and endoscopic therapy for delayed post-polypectomy hemorrhage. Gastrointest Endosc. 1992;38:127–9.

    Article  CAS  Google Scholar 

  60. Tseng CA, Chen LT, Tsai KB, Su YC, Wu DC, Jan CM, Wang WM, Pan YS. Acute hemorrhagic rectal ulcer syndrome: a new clinical entity? Report of 19 cases and review of the literature. Dis Colon Rectum. 2004;47:895–903; discussion 903–905

    Article  Google Scholar 

  61. Jafri SM, Monkemuller K, Lukens FJ. Endoscopy in the elderly: a review of the efficacy and safety of colonoscopy, esophagogastroduodenoscopy, and endoscopic retrograde cholangiopancreatography. J Clin Gastroenterol. 2010;44(3):161–6.

    Article  Google Scholar 

  62. Hilton D, Iman N, Burke GJ, Moore A, O’Mara G, Signorini D, Lyons D, Banerjee AK, Clinch D. Absence of abdominal pain in older persons with endoscopic ulcers: a prospective study. Am J Gastroenterol. 2001;96:380–4.

    Article  CAS  Google Scholar 

  63. Waye JD, Bashkoff E. Total colonoscopy: is it always possible? Gastrointest Endosc. 1991;37:152–4.

    Article  CAS  Google Scholar 

  64. Zuckerman DA, Bocchini TP, Birnbaum EH. Massive hemorrhage in the lower gastrointestinal tract in adults: diagnostic imaging and intervention. Am J Roentgenol. 1993;161:703–11.

    Article  CAS  Google Scholar 

  65. Christe C, Janssens JP, Armenian B, Herrmann F, Vogt N. Midazolam sedation for upper gastrointestinal endoscopy in older persons: a randomized, double-blind, placebo-controlled study. J Am Geriatr Soc. 2000;48(11):1398–403.

    Article  CAS  Google Scholar 

  66. Katschinski B, Logan R, Davies J, Faulkner G, Pearson J, Langman M. Prognostic factors in upper gastrointestinal bleeding. Dig Dis Sci. 1994;39(4):706–12.

    Article  CAS  Google Scholar 

  67. Hammond KL, et al. Implications of negative technetium 99m-labeled red blood cell scintigraphy in patients presenting with lower gastrointestinal bleeding. Am J Surg. 2007;193:404–7.

    Article  Google Scholar 

  68. Green BT, et al. Urgent colonoscopy for the evaluation and management of acute lower gastrointestinal hemorrhage: a randomized controlled trial. Am J Gastroenterol. 2005;100:2395–402.

    Article  Google Scholar 

  69. Laine L, Sahota A, Shah A. Does capsule endoscopy improve outcomes in obscure gastrointestinal bleeding? Randomized trial versus dedicated small bowel radiography. Gastroenterology. 2010;138(5):1673.e1–80.e1; quiz e11–2

    Article  Google Scholar 

  70. Orlando G, Luppino IM, Lerose MA, Gervasi R, Amato B, Silecchia G, Puzziello A. Feasibility of capsule endoscopy in elderly patients with obscure gastrointestinal bleeding. An up-to-date report. BMC Surg. 2012;12(Suppl 1):S30. https://doi.org/10.1186/1471-2482-12-S1-S30.

    Article  PubMed  PubMed Central  Google Scholar 

  71. Baradarian R, et al. Early intensive resuscitation of patients with upper gastrointestinal bleeding decreases mortality. Am J Gastroenterol. 2004;99:619–22.

    Article  Google Scholar 

  72. Hasselgren G, et al. Risk factors for rebleeding and fatal outcome in elderly patients with acute peptic ulcer bleeding. Eur J Gastroenterol Hepatol. 1998;10:667–72.

    Article  CAS  Google Scholar 

  73. Qureshi WA, Zuckerman MJ, Adler DG, Davila RE, Egan JV, Gan SI, et al. ASGE guideline: modifications in endoscopic practice for the elderly. Gastrointest Endosc. 2006;63(4):566–9.

    Article  Google Scholar 

  74. Sarin N, Monga N, Adams PC. Time to endoscopy and outcomes in upper gastrointestinal bleeding. Can J Gastroenterol. 2009;23(7):489–93.

    Article  CAS  Google Scholar 

  75. Gilbert DA, Silverstein FE, Tedesco FJ. National ASGE survey on upper gastrointestinal bleeding: complications of endoscopy. Dig Dis Sci. 1981;26(7 Suppl):55S–9.

    Article  CAS  Google Scholar 

  76. Gilbert DA, Silverstein FE, Tedesco FJ, Buenger NK, Persing J. The national ASGE survey on upper gastrointestinal bleeding. III. Endoscopy in upper gastrointestinal bleeding. Gastrointest Endosc. 1981;27(2):94–102.

    Article  CAS  Google Scholar 

  77. Lipof T, Sardella WV, Bartus CM, Johnson KH, Vignati PV, Cohen JL. The efficacy and durability of super-selective embolization in the treatment of lower gastrointestinal bleeding. Dis Colon Rectum. 2008;51(3):301–5.

    Article  CAS  Google Scholar 

  78. Kuo WT. Transcatheter treatment for lower gastrointestinal hemorrhage. Tech Vasc Interv Radiol. 2004;7(3):143–50.

    Article  Google Scholar 

  79. Bandi R, Shetty PC, Sharma RP, Burke TH, Burke MW, Kastan D. Superselective arterial embolization for the treatment of lower gastrointestinal hemorrhage. J Vasc Interv Radiol. 2001;12(12):1399–405.

    Article  CAS  Google Scholar 

  80. Kuo WT, Lee DE, Saad WE, Patel N, Sahler LG, Waldman DL. Superselective microcoil embolization for the treatment of lower gastrointestinal hemorrhage. J Vasc Interv Radiol. 2003;14(12):1503–9.

    Article  Google Scholar 

  81. Clark RA, Colley DP, Eggers FM. Acute arterial gastrointestinal hemorrhage: efficacy of transcatheter control. Am J Roentgenol. 1981;136(6):1185–9.

    Article  CAS  Google Scholar 

  82. Clarke MG, Bunting D, Smart NJ, Lowes J, Mitchell SJ. The surgical management of acute upper gastrointestinal bleeding: a 12-year experience. Int J Surg. 2010;8(5):377–80.

    Article  CAS  Google Scholar 

  83. Gianfrancisco JA, Abcarian H. Pitfalls in the treatment of massive lower gastrointestinal bleeding with “blind” subtotal colectomy. Dis Colon Rectum. 1982;25(5):441–5.

    Article  CAS  Google Scholar 

  84. Setya V, Singer JA, Minken SL. Subtotal colectomy as a last resort for unrelenting, unlocalized, lower gastrointestinal hemorrhage: experience with 12 cases. Am Surg. 1992;58(5):295–9.

    CAS  PubMed  Google Scholar 

  85. Bender JS, et al. Morbidity and mortality following total abdominal colectomy for massive lower gastrointestinal bleeding. Am Surg. 1991;57:536–40.

    CAS  PubMed  Google Scholar 

  86. Sung J, Lau J, Ching J, et al. Early reintroduction of aspirin with proton pump inhibitor after endoscopic hemostasis for peptic ulcer bleeding. Gut. 2007;56:A27.

    Article  Google Scholar 

  87. Pilotto A. Helicobacter pylori-associated peptic ulcer disease in older patients: current management strategies. Drugs Aging. 2001;18:487–94.

    Article  CAS  Google Scholar 

  88. Pilotto A, Franceschi M, Di Mario F, et al. The long-term clinical outcome of elderly patients with Helicobacter pylori-associated peptic ulcer disease. Gerontology. 1998;44:153–8.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Fugazzola, P. et al. (2018). Upper and Lower Gastrointestinal Bleeding. In: Crucitti, A. (eds) Surgical Management of Elderly Patients. Springer, Cham. https://doi.org/10.1007/978-3-319-60861-7_31

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-60861-7_31

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-60860-0

  • Online ISBN: 978-3-319-60861-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics