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Gastroesophageal Reflux in Children pp 251–268Cite as

Gastroesophageal Reflux Disease and Helicobacter pylori in Children

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Abstract

There is a complex relationship among H. pylori, gastric acid production, and the development of reflux symptoms and disease. Studies that fail to address this complexity will not provide clear information on which to base clinical decisions and still not well understood in adults as well as in children.

The implications of H. pylori infection for the acquisition of GERD are a matter of current controversy. Some studies suggest a causative association between H. pylori infection and GERD, whereas others postulate a protective role for H. pylori infection. On balance and based on the pediatric published data, we consider that H. pylori eradication more likely to provide benefits than harm in children with GERD.

Frequency of GERD and clinical manifestations of H. pylori infection; relationship of H. pylori and erosive reflux disease; relationship of GERD and H. pylori CagA and VacA and other genes’ status; effect of H. pylori and type of gastritis on gastrin, ghrelin, motilin, and GERD; influence of H. pylori eradication on GERD symptoms; and, finally, influence of H. pylori on the development of EoE in children were all summarized in this chapter.

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Abbreviations

CagA:

Cytotoxin-associated gene A

DU:

Duodenal ulcers

EoE:

Eosinophilic esophagitis

ENT:

Ear nose throat

eos/HPF:

Eosinophils per high-power field

GERD:

Gastroesophageal reflux disease

GER:

Gastroesophageal reflux

H. pylori :

Helicobacter pylori

IgE:

Immunoglobulin E

LESP:

Lower esophageal sphincter pressure

NUD:

Non-ulcer dyspepsia

NERD:

Nonerosive reflux disease

RUT:

Rapid urease test

RAP:

Recurrent abdominal pain

RE:

Reflux esophagitis

PCR:

Polymerase chain reaction

PPI:

Proton pump inhibitor

upper GI endoscopy:

Upper gastrointestinal endoscopy

References

  1. Koletzko S, Jones NL, Goodman K, Rowland M, Cadranel S, Chong S, et al. Evidence-based guidelines from ESPGHAN and NASPGHAN for Helicobacter pylori infection in children. J Pediatr Gastroenterol Nutr. 2011;53:230–43.

    PubMed  Google Scholar 

  2. Gold B. Outcome of pediatric gastroesophageal reflux disease: in the first year of life, in childhood, and in adults…oh, and should we really leave Helicobacter pylori alone? J Pediatr Gastroenterol Nutr. 2003;37(Suppl 1):S33–9.

    Article  PubMed  Google Scholar 

  3. Schwizer W, Fox M. Helicobacter pylori and gastro-esophageal reflux disease: a complex organism in a complex host. J Pediatr Gastroenterol Nutr. 2004;38:12–5.

    Article  PubMed  Google Scholar 

  4. Xinias I, Maris T, Mavroudi A, Panteliadis C, Vandenplas Y. Helicobacter pylori infection has no impact on manometric and pH-metric findings in adolescents and young adults with gastro-esophageal reflux and antral gastritis: eradication results to no significant clinical improvement. Pediatr Rep. 2013;5(e3):13–6.

    Google Scholar 

  5. Abdollahi A, Morteza A, Khalilzadeh O, Zandieh A, Asgarshirazi M. The role of Helicobacter pylori infection in gastro-esophageal reflux in Iranian children. Ann Trop Paediatr. 2011;31:53–7.

    Article  CAS  PubMed  Google Scholar 

  6. Brazowski J, Nowak A, Szaflarska-Poptawska A. Prevalence of Helicobacter pylori infection among children and youth with acid gastro-esophageal reflux. Przegl Lek. 2006;63:128–30. [Article in Polish]

    PubMed  Google Scholar 

  7. Rintala R, Kokkonen ML, Lindahi H, Sariola H. Does disordered upper gastrointestinal motility predispose to Helicobacter pylori colonization of the stomach in children? J Pediatr Surg. 1994;29:734–7.

    Article  CAS  PubMed  Google Scholar 

  8. Daugule I, Rumba I, Alksnis J, Ejderhamn J. Helicobacter pylori infection among children with gastrointestinal symptoms: a high prevalence of infection among patients with reflux oesophagitis. Acta Paediatr. 2007;96:1047–9.

    Article  PubMed  Google Scholar 

  9. Bitar M, Mahfouz R, Soweid A, Racoubian E, Ghasham M, Zaatari G, et al. Does Helicobacter pylori colonize the nasopharynx of children and contribute to their middle ear disease? Acta Otolaryngol. 2006;126:154–9.

    Article  PubMed  Google Scholar 

  10. Katra R, Kabelka Z, Jurovcik M, Hradsky O, Kraus J, Pavlik E, et al. Pilot study: association between Helicobacter pylori in adenoid hyperplasia and reflux episodes detected by multiple intraluminal impedance in children. Int J Pediatr Otorhinolaryngol. 2014;78:1243–9.

    Article  CAS  PubMed  Google Scholar 

  11. Aydin E, Aydogan F, Tastan E, Arslan M, Karaca G. Does Helicobacter pylori have a role in the etiology of adenoid hypertrophy? Indian J Otolaryngol Head Neck Surg. 2014;66(Suppl 1):S65–70.

    Article  Google Scholar 

  12. Asilsoy S, Babayigit A, Olmez D, Uzuner N, Karaman O, Oren O, et al. Helicobacter pylori infection and gastro-esophageal reflux in asthmatic children. J Trop Pediatr. 2008;54:129–32.

    Article  PubMed  Google Scholar 

  13. Nijevitch AA, Loguinovskaya VV, Tyrtyshnaya LV, Sataev VU, Ogorodnikova IN, Nuriakhmetova AN. Helicobacter pylori infection and reflux esophagitis in children with chronic asthma. J Clin Gastroenterol. 2004;38:14–8.

    Article  PubMed  Google Scholar 

  14. Rosioru C, Glassman MS, Halata MS, Schwarz SM. Esophagitis and Helicobacter pylori in children: incidence and therapeutic implications. Am J Gastroenterol. 1993;88:510–3.

    PubMed  CAS  Google Scholar 

  15. Pollet S, Gottrand F, Vincent P, Kalach N, Michaud L, Guimber D, et al. Gastroesophageal reflux disease and Helicobacter pylori Infection In neurologically impaired children: inter-relation and therapeutic Implication. J Pediatr Gastroenterol Nutr. 2004;38:70–4.

    Article  PubMed  Google Scholar 

  16. Emiroglu HH, Sokucu S, Suoglu OD, Gulluoglu M, Gokce S. Is there a relationship between Helicobacter pylori infection and erosive reflux disease in children. Acta Paediatr. 2010;99:121–5.

    Article  PubMed  Google Scholar 

  17. Lupu VV, Ignat A, Ciubotariu G, Ciubara A, Moscalu M, Burlea M. Helicobacter pylori infection and gastro-esophageal reflux in children. Dis Esophagus. 2015; doi:10.1111/dote.12429. [Epub ahead of print]

  18. Zagorskï SE, Voïtovich TN. Clinical epidemic interaction of reflux esophagitis and Helicobacter pylori infection in children and adolescents. Eksp Klin Gastroenterol. 2012;5:29–33. [Article in Russian]

    Google Scholar 

  19. Elitsur Y, Paul D, Zandra L, Mary R. Does Helicobacter pylori protect children from reflux disease? J Clin Gastroenterol. 2008;42:215–6.

    Article  PubMed  Google Scholar 

  20. Moon A, Solomon A, Beneck D, Cunningham-Rundles S. Positive association between Helicobacter pylori and gastro-esophageal reflux disease in children. J Pediatr Gastroenterol Nutr. 2009;49:283–8.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Levine A, Milo T, Broide E, Wine E, Dalal I, Boaz M, et al. Influence of Helicobacter pylori eradication on gastro-esophageal reflux symptoms and epigastric pain in children and adolescents. Pediatrics. 2004;113:54–8.

    Article  PubMed  Google Scholar 

  22. Canbakan B, Dobrucali A, Celik A, Canbakan M, Bal K, Erzin Y, et al. Gastritis localization and GERD incidence in patients with Cag A (+) and Cag A (-) Helicobacter pylori infection. Wien Med Wochenschr. 2000;150:91–3. [Article in German]

    PubMed  CAS  Google Scholar 

  23. Sökücü S, Ozden AT, Süoglu OD, Elkabes B, Demir F, Cevikbas U, et al. CagA positivity and its association with gastro-duodenal disease in Turkish children undergoing endoscopic investigation. J Gastroenterol. 2006;41:533–9.

    Article  CAS  PubMed  Google Scholar 

  24. Mendoza-Elizalde S, Cortés-Marquez AC, Giono-Cerezo S, Zuniga G, Consuelo-Sanchez A, Valencia-Mayoral P, et al. Analysis of the genotypic diversity of strains of Helicobacter pylori isolated from pediatric patients in Mexico. Infect Genet Evol. 2015;29:68–74.

    Article  CAS  PubMed  Google Scholar 

  25. Reshetnikov OV, Kurilovich SA, Krotova VA, Krotov SA. Helicobacter pylori and symptoms of gastro-esophageal reflux in adolescents: role of cagA-comprising strains. Eksp Klin Gastroenterol. 2006;115:25–7. [Article in Russian]

    Google Scholar 

  26. Biernat MM, Gosciniak G, Iwanczak B. Prevalence of Helicobacter pylori cagA, VacA, iceA, babA2 genotypes in Polish children and adolescents with gastroduodenal disease. Postepy Hig Med Dosw. 2014;68:1015–21.

    Article  Google Scholar 

  27. Nordenstedt H, Nilsson M, Johnsen R, Lagergren J, Hveem K. Helicobacter pylori infection and gastroesophageal reflux in a population-based study (The HUNT Study). Helicobacter. 2007;12:16–22.

    Article  PubMed  Google Scholar 

  28. Eren M, Colak O, Isiksoy S, Yavuz A. Effect of Helicobacter pylori infection on gastrin, ghrelin, motilin, and gastro-esophageal reflux. Turk J Gastroenterol. 2015;26:367–72.

    Article  PubMed  Google Scholar 

  29. Zullo A, Hassan C, Repici A, Bruzzese V. Helicobacter pylori eradication and reflux disease onset: did gastric acid get “crazy”? World J Gastroenterol. 2013;19:786–9.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Nwokolo CU, Freshwater DA, O’Hare P, Randeva HS. Plasma ghrelin following cure of Helicobacter pylori. Gut. 2003;52:637–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. JC W, Sung JJ, Ng EK, et al. Prevalence and distribution of Helicobacter pylori in gastro-oesophageal reflux disease: a study from the East. Am J Gastroenterol. 1999;94:1790–4.

    Article  Google Scholar 

  32. Peitz U, Wex T, Vieth M, et al. Correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: a matched-pairs study. J Gastroenterol Hepatol. 2011;26:82–9.

    Article  PubMed  Google Scholar 

  33. JC W, Sung JJ, Chan FK, et al. Helicobacter pylori infection is associated with milder gastrooesophageal reflux disease. Aliment Pharmacol Ther. 2000;14:427–32.

    Article  Google Scholar 

  34. Cam S. Risk of gastric cancer in children with H. Pylori infection. APJCP. 2014;15:9905–8.

    PubMed  Google Scholar 

  35. Kalach N, Huvenne H, Gosset P, Papadopoulos S, Dehecq E, Decoster A, et al. Eosinophils counts in upper digestive mucosa of West European children: variations with age, organs, symptoms, Helicobacter pylori status and pathologic findings. J Pediatr Gastroenterol Nutr. 2011;52:175–82.

    Article  CAS  PubMed  Google Scholar 

  36. Elitsur Y, Alrazzak BA, Preston D, Demetieva Y. Does Helicobacter pylori protect against eosinophilic esophagitis in children? Helicobacter. 2014;19:367–71.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Clinique Pédiatrique St Antoine, Hôpital St Vincent de Paul, Groupement des Hôpitaux de l’Institut Catholique de Lille (GHICL), Catholic University of Lille, BD de Belfort, 59020, Lille Cedex, France

    Nicolas Kalach

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Correspondence to Nicolas Kalach .

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Editors and Affiliations

  1. Universitair Ziekenhuis Brussel, Kidz Health Castle, Brussels, Belgium

    Yvan Vandenplas

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Kalach, N. (2017). Gastroesophageal Reflux Disease and Helicobacter pylori in Children. In: Vandenplas, Y. (eds) Gastroesophageal Reflux in Children. Springer, Cham. https://doi.org/10.1007/978-3-319-60678-1_18

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  • DOI: https://doi.org/10.1007/978-3-319-60678-1_18

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