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Gastroesophageal Reflux in Children pp 237–250Cite as

Duodenogastroesophageal Reflux

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Abstract

Gastroesophageal reflux disease is a multifactorial disorder in children and adults and results from reflux of gastric contents into the esophagus. Animal studies suggest the possibility of synergism between acid and pepsin and conjugated bile acids with a damaging potential for the esophageal mucosa. Human studies show an interaction between acid and duodenogastroesophageal reflux in inducing lesions. Gastroesophageal reflux symptoms are more related to acid reflux events than to non-acid reflux events. The role of duodenogastroesophageal reflux has been evaluated by endoscopy with biopsies, scintigraphy, aspiration studies, esophageal pH-monitoring/impedance, and bilirubin monitoring. Therapeutic options are reducing the secretion of gastric acid, prokinetics, baclofen, surgery, and mucosal protective agents.

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Abbreviations

DGER:

Duodenogastroesophageal reflux

GERD:

Gastroesophageal reflux disease

GI:

Gastrointestinal

PPI:

Proton pump inhibitor

ROS:

Reactive oxygen species

TEER:

Transepithelial resistance

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Authors and Affiliations

  1. University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium

    Ilse Hoffman

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  1. Ilse Hoffman
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Correspondence to Ilse Hoffman .

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Editors and Affiliations

  1. Universitair Ziekenhuis Brussel, Kidz Health Castle, Brussels, Belgium

    Yvan Vandenplas

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Hoffman, I. (2017). Duodenogastroesophageal Reflux. In: Vandenplas, Y. (eds) Gastroesophageal Reflux in Children. Springer, Cham. https://doi.org/10.1007/978-3-319-60678-1_17

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  • DOI: https://doi.org/10.1007/978-3-319-60678-1_17

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-60677-4

  • Online ISBN: 978-3-319-60678-1

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