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Clinical Aspects of the Inherited Cerebellar Malformations

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Development of the Cerebellum from Molecular Aspects to Diseases

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

Inherited cerebellar malformations cause lifelong disability and are not well studied in the newborns because there is a lack of appropriate clinical examination tools. Recently, inherited cerebellar malformations have been investigated using emerging advanced neuroimaging technology such as MRI, which revealed many cerebellar developmental disorders. These malformations cause impairments that involve motor and non-motor functions. Cerebellar hypoplasia, Dandy–Walker syndrome, Joubert syndrome, pontocerebellar hypoplasia, and rhombencephalosynapsis are examples of cerebellar malformations. In this chapter we will focus on cerebellar malformations that have been reported using characteristic symptoms and signs. The current approach for evaluation of the affected patients, differential diagnosis, and management will be discussed.

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Authors and Affiliations

  1. Department of Pediatrics, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran

    Asghar Marzban

  2. Department of Pediatrics, Hazrat – E – Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran

    Mohammad Vafaee-shahi

  3. Department of Radiology, Valiasr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran

    Kamran Azarkhish

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  1. Asghar Marzban
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  2. Mohammad Vafaee-shahi
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  3. Kamran Azarkhish
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Correspondence to Asghar Marzban .

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Editors and Affiliations

  1. Department of Human Anatomy and Cell Science, The Children’s Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Science, University of Manitoba, Winnipeg, MB, Canada

    Hassan Marzban

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Marzban, A., Vafaee-shahi, M., Azarkhish, K. (2017). Clinical Aspects of the Inherited Cerebellar Malformations. In: Marzban, H. (eds) Development of the Cerebellum from Molecular Aspects to Diseases. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-59749-2_19

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