Abstract
This chapter outlines the pathophysiology, clinical presentation, inheritance, and incidence of factor XIII deficiency. The chapter describes the interaction with pregnancy and discusses the medical and anesthetic management of pregnant women with factor XIII deficiency, including treatment of acute hemorrhage.
Please also refer to chapter 88 “Inherited Bleeding Disorders”.
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References
Mumford A, Ackroyd S, Alikhan R, Bowles L, Chowsary P, Grainger J, et al. Guideline for the diagnosis and management of the rare coagulation disorders. A United Kingdom Haemophilia Centre Doctors’ Organization guideline on behalf of the British Committee for Standards in Haematology. Br J Haematol. 2014;167:304–26.
Kadir R, Davies J, Winikoff R, Pollard D, Peyvandi F, Garagiola I, et al. Pregnancy complications and obstetric care in women with inherited bleeding disorders. Haemophilia. 2013;19:1–10.
Chi C, Kadir R. Inherited bleeding disorders in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2012;26:103–17.
Pike G, Bolton-Maggs P. Factor deficiencies in pregnancy. Hematol Oncol Clin N Am. 2011;25:359–78.
Burrows R, Ray J, Burrows E. Bleeding risk and reproductive capacity among patients with factor XIII deficiency: a case presentation and review of the literature. Obstet Gynecol Surv. 2000;55:103–8.
Rodeghiero F, Castaman G, Di Bona E, Ruggeri M, Dinni E. Successful pregnancy in a woman with congenital factor XIII deficiency treated with substitute therapy. Blut. 1987;55:45–8.
Boda Z, Pfliegler G, Muszbek L, Tóth A, Avdány R, Hársfalvi J, et al. Congenital factor XIII deficiency with multiple benign breast tumours and successful pregnancy with substitutive therapy. Haemostasis. 1989;19:348–52.
Mikkola H, Muszbek L, Laiho E. Molecular mechanism of a mild phenotype in coagulation factor XIII (FXIII) deficiency: a splicing mutation permitting partial correct splicing of FXIII A-subunit mRNA. Blood. 1997;89:1279–87.
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Brown, J.P.R., Douglas, J. (2018). Factor XIII Deficiency. In: Mankowitz, S. (eds) Consults in Obstetric Anesthesiology. Springer, Cham. https://doi.org/10.1007/978-3-319-59680-8_62
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DOI: https://doi.org/10.1007/978-3-319-59680-8_62
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